Translation and Validation of the Brazilian Portuguese Version of the Gastrointestinal Symptom Rating Scale (Gsrs) Questionnaire

Souza, Givago da Silva; Sardá, Fabiana Andréa Hoffmann; Giuntini, Eliana Bistriche; Gumbrevicius, Iara; Morais, Mauro Batista de; Menezes, Elizabete Wenzel de

doi:10.1590/s0004-28032016000300005

Cited by 22 publications

(16 citation statements)

References 29 publications

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“…PwP and controls completed a 15‐question Gastrointestinal Symptom Rating Scale (GSRS) to evaluate the frequency and severity of gastrointestinal symptoms during the previous 3 months. The GSRS has previously been widely used to assess GI health in various conditions and in healthy populations 11,25–37 . Each symptom was rated on a 4‐point Likert‐type scale, with 0 being “normal, none or transient”, and 3 representing “frequent, continuous or most severe symptoms” 34,36 .…”

Section: Methodsmentioning

confidence: 99%

Characterization of Gastrointestinal Symptom Type and Severity in Parkinson's Disease: A Case–Control Study in an Australian Cohort

Kenna

Bakeberg

Gorecki

et al. 2021

Movement Disord Clin Pract

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BackgroundWhile constipation is a well‐known non‐motor symptom which may precede the onset of the classical motor symptoms of PD, there have been few comprehensive studies of gastrointestinal (GI) symptoms in people with PD (PwP).ObjectivesTo investigate the spectrum of GI symptoms in an Australian PwP cohort and their relationship to use of anti‐parkinsonian medications dietary habits and smoking.MethodsThe prevalence and severity of GI symptoms were compared in a group of 163 PwP and 113 healthy control subjects using the Gastrointestinal Symptom Rating Scale (GSRS). Corrected linear regression models were used to determine differences between PwP and controls, and to investigate the influence of different classes of anti‐Parkinsonian medications.ResultsPwP reported a greater frequency of constipation and GI‐associated illnesses when compared to healthy controls. Total GSRS scores (P < 0.0001), upper GI symptoms (P < 0.0001), and hypoactive GI Symptoms (P < 0.0001) were all significantly greater in the PD cohort than controls. Further analyses revealed a positive association between the use of anti‐Parkinsonian medications and total GSRS scores (P < 0.001), as well as upper GI symptoms (P < 0.001) and hypoactive GI function (P < 0.001).ConclusionsThis study illustrates the frequency and array of GI symptoms in a large PD cohort. The findings indicate that anti‐parkinsonian medications play an important role in the presentation and development of GI symptoms.

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Section: Methodsmentioning

confidence: 99%

Characterization of Gastrointestinal Symptom Type and Severity in Parkinson's Disease: A Case–Control Study in an Australian Cohort

Kenna

Bakeberg

Gorecki

et al. 2021

Movement Disord Clin Pract

View full text Add to dashboard Cite

show abstract

“…A Likert scale was used, in which 0 indicated the absence of symptoms and 7 indicated symptoms of an extreme degree. Scales can be grouped into blocks, such as abdominal pain, reflux, diarrhea, constipation, and indigestion (Souza et al, ). Subjects took this questionnaire at Weeks 0, 6, and 14.…”

Section: Methodsmentioning

confidence: 99%

Effect ofPereskia aculeataMill. in vitro and in overweight humans: A randomized controlled trial

et al. 2019

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Objectives: The objective of this study was to investigate the influence of ora‐pro‐nobis (Pereskia aculeata Mill.) flour on the adhesion of probiotics to intestinal epithelial cells and to evaluate the effect of a product based on this flour on gastrointestinal symptoms, weight, body fat, glycemia, and lipid profile in overweight men. Methods: Microbiological counts (probiotic count, survival after in vitro gastrointestinal resistance, Caco‐2 cell adhesion) were analyzed. A randomized, cross‐over intervention was performed. Intestinal microbiota was indirectly assessed on the basis of consistency, color of feces, and gastrointestinal symptoms. Results: P. aculeata did not affect Lactobacillus casei adhesion to Caco‐2 cells. Ora‐pro‐nobis flour improved gastrointestinal symptoms and increased satiety. Conclusion: The consumption of ora‐pro‐nobis flour improved intestinal health. In addition, it maintained the high adherence of L. casei to intestinal cells as well as patient anthropometric and biochemical parameters. Practical applications Pereskia aculeata Mill. is well known in folk medicine and has several nutrients; however, there are few studies on this plant. This is the first study to analyze the influence of P. aculeata on bacterial adherence and the first cross‐over clinical trial to evaluate the beneficial potential of ora‐pro‐nobis flour in overweight men. Thus, this study will contribute to the promotion of ora‐pro‐nobis as a functional ingredient and will arouse the interest of industries to develop related healthy foods. In addition, it is an effective dietary strategy to improve the gastrointestinal health of men.

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“…The total GSRS score ranged from 15 to 105 points. The higher the score, the higher the intensity and/or frequency of the symptom [46].…”

Section: Gastrointestinal Symptomsmentioning

confidence: 99%

Effect of Unripe Banana Flour on Gut-Derived Uremic Toxins in Individuals Undergoing Peritoneal Dialysis: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

et al. 2021

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In chronic kidney disease (CKD), the accumulation of gut-derived metabolites, such as indoxyl sulfate (IS), p-cresyl sulfate (pCS), and indole 3-acetic acid (IAA), has been associated with the burden of the disease. In this context, prebiotics emerge as a strategy to mitigate the accumulation of such compounds, by modulating the gut microbiota and production of their metabolites. The aim of this study was to evaluate the effect of unripe banana flour (UBF—48% resistant starch, a prebiotic) on serum concentrations of IS, pCS, and IAA in individuals undergoing peritoneal dialysis (PD). A randomized, double-blind, placebo-controlled, crossover trial was conducted. Forty-three individuals on PD were randomized to sequential treatment with UBF (21 g/day) and placebo (waxy corn starch—12 g/day) for 4 weeks, or vice versa (4-week washout). The primary outcomes were total and free serum levels of IS, pCS, and IAA. Secondary outcomes were 24 h urine excretion and dialysis removal of IS, pCS, and IAA, serum inflammatory markers [high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), interleukin-10 (IL-10), and tumor necrosis factor-α (TNF-α)], serum lipopolysaccharide LPS, and dietary intake. Of the 43 individuals randomized, 26 completed the follow-up (age = 55 ± 12 years; 53.8% men). UBF did not promote changes in serum levels of IS (p = 0.70), pCS (p = 0.70), and IAA (p = 0.74). Total serum IS reduction was observed in a subgroup of participants (n = 11; placebo: median 79.5 μmol/L (31–142) versus UBF: 62.5 μmol/L (31–133), p = 0.009) who had a daily UBF intake closer to that proposed in the study. No changes were observed in other secondary outcomes. UBF did not promote changes in serum levels of IS or pCS and IAA; a decrease in IS was only found in the subgroup of participants who were able to take 21g/day of the UBF.

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Translation and Validation of the Brazilian Portuguese Version of the Gastrointestinal Symptom Rating Scale (Gsrs) Questionnaire

Abstract: - The GSRS was translated and validated into Brazilian Portuguese, with appropriate internal consistency and reliability and is available to be used in assessments of bowel function.

Cited by 22 publications

References 29 publications

Characterization of Gastrointestinal Symptom Type and Severity in Parkinson's Disease: A Case–Control Study in an Australian Cohort

Characterization of Gastrointestinal Symptom Type and Severity in Parkinson's Disease: A Case–Control Study in an Australian Cohort

Effect ofPereskia aculeataMill. in vitro and in overweight humans: A randomized controlled trial

Effect of Unripe Banana Flour on Gut-Derived Uremic Toxins in Individuals Undergoing Peritoneal Dialysis: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial

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