The Neurological Face of Celiac Disease

Işıkay, Sedat; Kocamaz, Halil

doi:10.1590/s0004-28032015000300002

Cited by 23 publications

(19 citation statements)

References 19 publications

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“…Clearly such findings are relevant to clinical practice, as both ASD and ADHD patients are often advised to adopt a GFD to reduce behavioural problems [38,[40][41][42][43][44][45][46]. There is no rational for doing so unless the patient has been tested for CD prior to adopting a GFD.…”

Section: Discussionmentioning

confidence: 99%

“…The eight articles included a total of 12,366 participants. The prevalence of ADHD in CD was assessed by one case series study [41] two cross sectional studies [42,43] two case-controlled studies [34,44] and one cohort study [40]. Out of 11,965 CD participants, 165 were found to have ADHD resulting in a pooled prevalence of ADHD in CD of 1.4%.…”

Section: Asd and Adhdmentioning

confidence: 99%

“…Thirdly, despite much deliberation surrounding increases in GI symptoms and intestinal permeability in ASD mentioned in these articles, only two tested these theories [38,39]. Lastly, it is also worth considering that the majority of these studies for both ASD and ADHD concern pediatric populations, which is understandable as ASD and ADHD are both prevalent in childhood [31,34,35,[37][38][39][40][41][42]45,46]. However, unlike ASD and ADHD, CD is not confined to childhood and is very prevalent later on in life [45].…”

Section: Limitations Of Studies In Adhd and Asdmentioning

confidence: 99%

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Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis

2020

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Background: Coeliac disease (CD) is increasingly prevalent and is associated with both gastrointestinal (GI) and extra-intestinal manifestations. Psychiatric disorders are amongst extra-intestinal manifestations proposed. The relationship between CD and such psychiatric disorders is not well recognised or understood. Aim: The aim of this systematic review and meta-analysis was to provide a greater understanding of the existing evidence and theories surrounding psychiatric manifestations of CD. Methodology: An online literature search using PubMed was conducted, the prevalence data for both CD and psychiatric disorders was extracted from eligible articles. Meta analyses on odds ratios were also performed. Results: A total of 37 articles were included in this review. A significant increase in risk was detected for autistic spectrum disorder (OR 1.53, 95% CI 1.24–1.88, p < 0.0001), attention deficit hyperactivity disorder (OR 1.39, 95% CI 1.18–1.63, p < 0.0001), depression (OR 2.17, 95% CI 2.17–11.15, p < 0.0001), anxiety (OR 6.03, 95% CI 2.22–16.35, p < 0.0001), and eating disorders (OR 1.62, 95% CI 1.37–1.91, p < 0.00001) amongst the CD population compared to healthy controls. No significant differences were found for bipolar disorder (OR 2.35, 95% CI 2.29–19.21, p = 0.43) or schizophrenia (OR 0.46, 95% CI 0.02–10.18, p = 0.62). Conclusion: CD is associated with an increased risk of depression, anxiety, eating disorders as well as ASD and ADHD. More research is required to investigate specific biological explanations as well as any effect of gluten free diet.

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Section: Discussionmentioning

confidence: 99%

Section: Asd and Adhdmentioning

confidence: 99%

Section: Limitations Of Studies In Adhd and Asdmentioning

confidence: 99%

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Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis

2020

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“…Many organs or systems such as cardiac, neurological, bone, skin, liver, and endocrin may be involved in the course of CD (13)(14)(15)(16)(17)(18)(19). Although it is an intestinal autoimmune disease, as the diagnostic age of CD getting older, the disease presents itself with complaints that not directed to gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

Fluctuation of liver transaminases with gluten-free diet compliance of a patient with celiac disease and autoimmune hepatitis; a case report

Uyar¹,

Harmandar²,

Gulenay³

et al. 2017

J Turgut Ozal Med Cent

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Although the association of celiac disease with autoimmune hepatitis is well-known, the effect of gluten-free diet on autoimmune hepatitis progression is poorly deafined. We described a patient with celiac disease coexisting with autoimmune hepatitis and effectiveness of gluten-free diet on both diseases. A young patient with eleveted serum liver transaminases was diagnosed as celiac disease and autoimmune hepatitis according to clinical, laboratory and pathological findings. Clinical complaints and laboratory findings of patients resolved exactly after glutenfree diet. However, liver transaminases eleveted and clinical manifestations re-emerged when he left the diet. Clinicians should consider that other autoimmune diseases may occur in the course celiac disease and gluten-free diet may improve also extra-intestinal manifestations of celiac disease.

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“…Çölyak hastalığının nörolojik hastalıklarla ilişkisi bilinmektedir. Epilepsi, ataksi, nöropati, miyopati ve baş ağrısı ilişkili olduğu bilinen nörolojik hastalıklardır 2 . Çölyak hastalığı ve febril konvülziyon (FK) birlikteliği sık olmamakla birlikte, literatürde bildirilmiştir 3 .…”

Section: Introductionunclassified

Breath holding spell, febrile seizure and anemia; are those parts of a puzzle? Celiac disease-case report

Kocamaz¹,

Işıkay²

2017

MMJ

Self Cite

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The Neurological Face of Celiac Disease

Abstract: It is important to keep in mind that in clinical course of celiac disease different neurological manifestations may be reported.

Cited by 23 publications

References 19 publications

Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis

Psychiatric Manifestations of Coeliac Disease, a Systematic Review and Meta-Analysis

Fluctuation of liver transaminases with gluten-free diet compliance of a patient with celiac disease and autoimmune hepatitis; a case report

Breath holding spell, febrile seizure and anemia; are those parts of a puzzle? Celiac disease-case report

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