Nutritional, Metabolic and Cardiovascular Correlations of Morning Cortisol in Health Care Workers in a Gastroenterology Service

Guerra, A. R. G.; Soares, Rafael Marques; Pezzi, Fernanda Aparecida Szareski; Karkow, Francisco; Faintuch, Joel

doi:10.1590/s0004-28032015000200003

Cited by 3 publications

(2 citation statements)

References 29 publications

(64 reference statements)

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“…No such correlation was found in healthy individuals with normal BMI. Our results are in accord with previous observations based on a relatively young cohort (mean age 33 ± 9.8) also showing age-related decline in cortisol values [58]. These results, however, appear to contradict other reports that demonstrated increased or maintained activity of the HPA axis during aging presumably participating in the development of depression and frailty in the elderly [59–62].…”

Section: Discussionsupporting

confidence: 88%

In Obesity, HPA Axis Activity Does Not Increase with BMI, but Declines with Aging: A Meta-Analysis of Clinical Studies

et al. 2016

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BackgroundObesity is one of the major public health challenges worldwide. It involves numerous endocrine disorders as etiological factors or as complications. Previous studies strongly suggested the involvement of the hypothalamic-pituitary-adrenal (HPA) axis activity in obesity, however, to date, no consistent trend in obesity-associated alterations of the HPA axis has been identified. Aging has been demonstrated to aggravate obesity and to induce abnormalities of the HPA axis. Thus, the question arises whether obesity is correlated with peripheral indicators of HPA function in adult populations.ObjectivesWe aimed to meta-analyze literature data on peripheral cortisol levels as indicators of HPA activity in obesity during aging, in order to identify possible explanations for previous contradictory findings and to suggest new approaches for future clinical studies.Data Sources3,596 records were identified through searching of PubMed, Embase and Cochrane Library Database. Altogether 26 articles were suitable for analyses.Study Eligibility CriteriaEmpirical research papers were eligible provided that they reported data of healthy adult individuals, included body mass index (BMI) and measured at least one relevant peripheral cortisol parameter (i.e., either morning blood cortisol or 24-h urinary free cortisol).Statistical MethodsWe used random effect models in each of the meta-analyses calculating with the DerSimonian and Laird weighting methods. I-squared indicator and Q test were performed to assess heterogeneity. Meta-regression was applied to explore the effect of BMI and age on morning blood and urinary free cortisol levels. To assess publication bias Egger’s test was used.ResultsObesity did not show any correlation with the studied peripheral cortisol values. On the other hand, peripheral cortisol levels declined with aging within the obese, but not in the non-obese groups.ConclusionsOur analysis demonstrated that obesity or healthy aging does not lead to enhanced HPA axis activity, peripheral cortisol levels rather decline with aging.

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Section: Discussionsupporting

confidence: 88%

In Obesity, HPA Axis Activity Does Not Increase with BMI, but Declines with Aging: A Meta-Analysis of Clinical Studies

et al. 2016

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“…Then, ACTH stimulates the adrenal cortex to secrete cortisol in order to increase energy availability [15,43], but in a long term, this response can be deleterious. On healthcare professionals, the explored deleterious effects of stress on physiological status comprise alterations on energetic metabolism and body mass [44]. Additionally, stress hormones impair plasticity in the hippocampus of animals [45] and human beings, affecting learning skills [16] and contributing to the development of pathologies as anxiety and depression [46,47].…”

Section: Neuroendocrine Responses In Stressed Nursing Studentsmentioning

confidence: 99%

Stress in Nursing University Students and Mental Health

Pulido-Criollo¹,

Cueto‐Escobedo²,

Ruiz³

2018

Health and Academic Achievement

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Stress is a physiological response that impacts the cognitive, emotional, behavioral, and social components. It also involves the adaptation of the organism, the coping resources, and the environment. In young people, stress can be triggered by social interactions or school requirements. This chapter is a narrative review analyzing scientific bibliography from the main databases (NIH, Scielo, Redalyc) that explored the main stressors and their effects on nursing students. These stressors include the care of patients, assignments and workloads, academic evaluations, and negative or hostile social interactions. Data include the deleterious effects of stress in nursing students as anxiety, depression, inhibiting learning, and burnout, which negatively impact their academic development and health. Finally, some interventions to reduce the impact of stress are discussed. Conclusion: Stress responses in nursing students vary in duration and intensity during their academic training; final effects depend on the coping mechanisms, individual resources, and hospital environment. The effects of stress on nursing students impact on academic performance but could also trigger several psychiatric disorders as depression or anxiety, as well as other associated problems such as sleep disorders, alcohol, and psychoactive drug consumption, which in the short and long term may affect the patient care.

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Basal cortisol levels and metabolic syndrome: A systematic review and meta-analysis of observational studies

Garcez

Leite

Weiderpass

et al. 2018

Psychoneuroendocrinology

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Nutritional, Metabolic and Cardiovascular Correlations of Morning Cortisol in Health Care Workers in a Gastroenterology Service

Cited by 3 publications

References 29 publications

In Obesity, HPA Axis Activity Does Not Increase with BMI, but Declines with Aging: A Meta-Analysis of Clinical Studies

In Obesity, HPA Axis Activity Does Not Increase with BMI, but Declines with Aging: A Meta-Analysis of Clinical Studies

Stress in Nursing University Students and Mental Health

Basal cortisol levels and metabolic syndrome: A systematic review and meta-analysis of observational studies

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