Gastric cancer trends in epidemiology

Zilberstein, Bruno; Jacob, Carlos Eduardo; Cecconello, Ivan

doi:10.1590/s0004-28032012000300001

Cited by 13 publications

(8 citation statements)

References 7 publications

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“…Gastric cancer (GC) ranks amongst the most frequent causes of death in many parts of the world . Although better food preservation techniques have lowered the global incidence of GC, mortality associated with later stages of the disease remains disproportionately high . Since surgical resection coupled with peri‐operative chemotherapy effectively cures localised primary GC , it follows that ensuring early detection is a logical route to reduce this healthcare burden.…”

Section: Introductionmentioning

confidence: 99%

A simple biomarker scoring matrix for early gastric cancer detection

Yong

Chung

2016

Proteomics

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Gastric cancer (GC) is a major cause of death in many parts of the world. While 90% of early GC is curable by resection, only about 5% of patients diagnosed in the late stages survive beyond five years. This provides strong impetus to push for early GC detection through the use of non-invasive biomarkers, before metastatic complications arise. It is also of strong medical interest to identify patients of the diffuse subtype at the earliest time possible, since the disease variant progresses very rapidly and is associated with much higher mortality rate. In this study, we compared quantitatively the gastric fluid proteome of 70 GC patients to 17 individuals with benign gastritis in search of potential biomarkers that aid in GC diagnosis, prognosis and subtype stratification. We report that as much as half of the gastric fluid proteome is subject to regulation in diseased states, and propose a simple biomarker panel scoring matrix for early GC detection with diagnostic sensitivity of 95.7%. We also demonstrate as proof-of-concept that a digitised record generated with SWATH-MS based on 380 protein abundance signatures from the gastric fluid could segregate patients with diffuse-type GC.

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Section: Introductionmentioning

confidence: 99%

A simple biomarker scoring matrix for early gastric cancer detection

Yong

Chung

2016

Proteomics

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“…The perioperative blood transfusion (PBT) has been an effective treatment method for patients with lower hemoglobin or a large amount of blood loss during operation [1,2]. It has been reported that PBT was associated with poorer prognosis for patients with many solid tumor malignancies, including hepatocellular carcinoma, bladder cancer, colorectal cancer, and esophageal cancer [3e6].…”

Section: Introductionmentioning

confidence: 99%

Blood transfusion does not affect survival of gastric cancer patients

Cui

Deng

Ding

et al. 2016

Journal of Surgical Research

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“…Gastric cancer patients are usually faced with a poor prognosis due to diagnosis at later stages (8,24) . In these settings, combination therapy has become an established treatment for patients with locally advanced gastric cancer, whereas the high risk of locoregional relapses has favored the inclusion of radiotherapy as a perioperative component of its comprehensive therapeutic strategy.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of N-Ratio in Selecting Patients for Adjuvant Chemoradiotherapy After D2-Gastrectomy

Costa

Coimbra

Batista

et al. 2013

Arq. Gastroenterol.

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-Context -Whether adjuvant chemoradiotherapy may contribute to improve survival outcomes after D2-gastrectomy remains controvertial. Objective -To explore the clinical utility of N-Ratio in selecting gastric cancer patients for adjuvant chemoradiotherapy after D2-gastrectomy. Methods -A retrospective cohort study was carried out on gastric cancer patients who underwent D2-gastrectomy alone or D2-gastrectomy plus adjuvant chemoradiotherapy (INT-0116 protocol) at the Hospital A. C. Camargo from September 1998 to December 2008. Statistical analysis were performed using multiple conventional methods, such as c-statistic, adjusted Cox's regression and stratified survival analysis. Results -Our analysis involved 128 patients. According to c-statistic, the N-Ratio (i.e., as a continuous variable) presented "area under ROC curve" (AUC) of 0.713, while the number of metastatic nodes presented AUC of 0.705. After categorization, the cut-offs provide by Marchet et al. displayed the highest discriminating power -AUC value of 0.702. This N-Ratio categorization was confirmed as an independent predictor of survival using multivariate analyses.There also was a trend of better survival by adding of adjuvant chemoradiotherapy only for patients with milder degrees of lymphatic spread -5-year survival of 23.1% vs 66.9%, respectively (HR = 0.426, 95% CI 0.150-1.202; P = 0.092). Conclusions -This study confirms the N-Ratio as a tool to improve the lymph node metastasis staging in gastric cancer and suggests the cut-offs provided by Marchet et al. as the best way for its categorization after a D2-gastrectomy. In these settings, the N-Ratio appears a useful tool to select patients for adjuvant chemoradiotherapy, and the benefit of adding this type of adjuvancy to D2-gastrectomy is suggested to be limited to patients with milder degrees of lymphatic spread (i.e., NR2, 10%-25%).

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Gastric cancer trends in epidemiology

Cited by 13 publications

References 7 publications

A simple biomarker scoring matrix for early gastric cancer detection

A simple biomarker scoring matrix for early gastric cancer detection

Blood transfusion does not affect survival of gastric cancer patients

Evaluation of N-Ratio in Selecting Patients for Adjuvant Chemoradiotherapy After D2-Gastrectomy

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