Research on zinc blood levels and nutritional status in adolescents with autoimmune hepatitis

Pereira, Thalita Cremonesi; Saron, Margareth Lopes Galvão; Carvalho, Wagner A.; Vilela, Maria Marluce dos Santos; Höehr, Nelci Fenalti; Hessel, Gabriel

doi:10.1590/s0004-28032011000100013

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…Declines in the serum Zn [ 139 ] and Se [ 140 ] levels of patients with AIH have been reported. Indeed, lower serum Zn and Se levels were one of the common features in autoimmune diseases [ 141 , 142 ].…”

Section: The Roles Of Trace Elementsmentioning

confidence: 99%

Current Trends of Essential Trace Elements in Patients with Chronic Liver Diseases

Himoto

Masaki

2020

Nutrients

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Essential trace elements play crucial roles in the maintenance of health, since they are involved in many metabolic pathways. A deficiency or an excess of some trace elements, including zinc, selenium, iron, and copper, frequently causes these metabolic disorders such as impaired glucose tolerance and dyslipidemia. The liver largely regulates most of the metabolism of trace elements, and accordingly, an impairment of liver functions can result in numerous metabolic disorders. The administration or depletion of these trace elements can improve such metabolic disorders and liver dysfunction. Recent advances in molecular biological techniques have helped to elucidate the putative mechanisms by which liver disorders evoke metabolic abnormalities that are due to deficiencies or excesses of these trace elements. A genome-wide association study revealed that a genetic polymorphism affected the metabolism of a specific trace element. Gut dysbiosis was also responsible for impairment of the metabolism of a trace element. This review focuses on the current trends of four trace elements in chronic liver diseases, including chronic hepatitis, liver cirrhosis, nonalcoholic fatty liver disease, and autoimmune liver diseases. The novel mechanisms by which the trace elements participated in the pathogenesis of the chronic liver diseases are also mentioned.

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Section: The Roles Of Trace Elementsmentioning

confidence: 99%

Current Trends of Essential Trace Elements in Patients with Chronic Liver Diseases

Himoto

Masaki

2020

Nutrients

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“…Ainda, o Zn atua na maturação hepática da vitamina A e na fertilidade e reprodução em humanos (Gibson, 2012;Levenson & Morris, 2011). O Zn é um elemento essencial para as atividades celulares, atuando principalmente como cofator de várias enzimas e proteínas (Pereira et al, 2011). Andreini, Banci, Bertini, & Rosato (2006), baseando-se em análises de bioinformática, demonstraram que o Zn está presente em cerca de 3207 proteínas humanas.…”

Section: Zinco E a Nutrição Humanaunclassified

Zinco no solo, na planta e a saúde humana: uma revisão

Kachinski

Vidigal

Ávila

2020

RSD

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It is estimated that 17.3% of the world population is at risk for Zn deficiency, and annually, about half a million children under five years of age die from causes related to Zn malnutrition. Low-cost strategy to increase Zn intake by humans is to increase the consumption of biofortified crops. Biofortification comprises the process for increasing contents of one or more nutrients in the edible parts of agricultural crops in order to increase their nutritional value. For biofortification to reach one billion people by 2030, mutual efforts must be added. Among them, policies must place more emphasis on agriculture role in improving health. Governments and institutions must include biofortification on food security policy, and food processors and others responsible for production chain must include biofortified crops in their product lines. The objective of this study was to carry out a bibliographic review to elucidate the dynamics of Zn in soil, the essential function of Zn in plant yield, the plant role in transfer Zn to human body, the importance of Zn in the human health and current measures that have been taken to mitigate Zn malnutrition in the world.

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“…Yazar et al [76], however, found no differences in the plasma zinc concentrations of patients with RA. Patients with celiac disease [77][78][79][80], type-I diabetes mellitus [81,82], SLE [83,84], autoimmune hepatitis [85,86], primary biliary cirrhosis [87,88] and pemphigus vulgaris [89] also exhibited decreased serum zinc concentrations.…”

Section: Zinc Status In Patients With Autoimmune Diseasesmentioning

confidence: 99%

The influence of the trace element zinc on the immune system

Schubert

Guttek

Reinhold

et al. 2015

LaboratoriumsMedizin

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Clinical and experimental examinations showed a close relationship between zinc as an essential trace element and the immune system. Thus, cellular and humoral components from both the innate and the adaptive immune system are affected by zinc. Human zinc deficiencies are frequently connected with disturbed immune functions. Controlled zinc substitution results in a normalization of zinc serum levels, zinc homeostasis, and the immunological parameters. As shown in in vitro experiments, low zinc concentrations stimulate functional parameters of immune cells, but high zinc concentrations are suppressive or cytotoxic for these cells. Recently, the immunosuppressive effect of zinc was demonstrated in animal models of T-cell-dependent autoimmune diseases, like experimental autoimmune encephalomyelitis. Moreover, decreased serum/plasma zinc concentrations have been detected in patients with different autoimmune diseases. Prospective studies should verify the possibility of controlled immunosuppressive zinc therapies for these diseases.

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Research on zinc blood levels and nutritional status in adolescents with autoimmune hepatitis

Cited by 11 publications

References 14 publications

Current Trends of Essential Trace Elements in Patients with Chronic Liver Diseases

Current Trends of Essential Trace Elements in Patients with Chronic Liver Diseases

Zinco no solo, na planta e a saúde humana: uma revisão

The influence of the trace element zinc on the immune system

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