Evaluation of gastric histology in children and adolescents with Helicobacter pylori gastritis using the Update Sydney System

Abstract

-Context -Although Helicobacter pylori infection is prevalent in our country, there are few studies evaluating the associated histological abnormalities in children. Objective -To evaluate the histological features of the gastric mucosa in children and adolescents with Helicobacter pylori gastritis. Methods -One hundred and thirty two gastric biopsies from 22 symptomatic patients infected with H. pylori (14F/8M, median age 10 y 5 mo, age range 2 y 11 mo to 16 y 9 mo) were evaluated. Evaluated gastric regions included: antrum (lesser and greater curvature), corpus (lesser and greater curvature), incisura angularis and fundus. Histological examination was performed according to the Updated Sydney System, and regional scores for polymorphonuclear and mononuclear cell infiltrate as well as bacterial density were generated. Results -Fifteen (68.2%) patients presented H. pylori-chronic active gastritis, six (27.3%) presented antrum-predominant H. pylori-chronic active gastritis, and one (4.5%) presented corpus-predominant H. pylori-chronic active gastritis. Polymorphonuclear cell infiltrate and mononuclear cell infiltrate were observed in 93.9% and 98.5% of the biopsy specimens, respectively. Higher histological scores for polymorphonuclear infiltrate, mononuclear infiltrate, and bacterial density were observed in the gastric antrum. Intestinal metaplasia and gastric atrophy were not identified in any patient. Lymphoid aggregates and lymphoid follicles were observed in the gastric antrum of three (13.6%) and seven (31.8%) patients, respectively, but they were not related to antral nodularity. Conclusions -Chronic active gastritis was observed in all patients with H. pylori infection. However, antral or corporeal predominance was not observed in most patients.

Refractory Iron-deficiency Anemia and Autoimmune Atrophic Gastritis in Pediatric Age Group

“…3), 1 AAG/Hp + (#7) and 1 AAG/HpÀ (#8; Table 2). [16][17][18][19][20][21] Gastric dysplasia was not found in any patient. One patient (#3) had an additional marker of autoimmunity at diagnosis (Table 1).…”

“…3). Gastritis staging and grading were recorded according to the Sydney criteria from 0 to 3 (absent, light, moderate, and strong [16][17][18][19][20][21] ; Table 2). …”

Ultra-Deep Sequencing Reveals the microRNA Expression Pattern of the Human Stomach

“…Of the test subjects, 60% were males, the mean age was 39.1 (±12.8) years and 50% of the studied subjects tested positive for H. pylori , according to international criteria established for their identification [12], [13] (Table 2) (additional details are provided in Table S2 ).…”

“…H. pylori infection was diagnosed based on the typical appearance of the bacterium along the mucus layer covering the gastric mucous membrane Antral biopsies were taken for histology evaluation due to higher density of the bacteria in gastric antrum and to the excellent sensitivity of this diagnostic method, according to international criteria established for their identification [12], [13] (additional details are provided in Table S2 ).…”

Association between <i>Helicobacter pylori</i> Infection and Pathological Changes in the Gastric Mucosa in Chinese Children

“…Generally, the patients in the present study had a low prevalence of chronic atrophic gastritis, and no patients had severe chronic atrophic gastritis or intestinal metaplasia. Researchers from different countries have reported a varied incidence of gastric atrophy (0-72%) and intestinal metaplasia ( 0-21% ) in children (11,(25)(26)(27)(28). Genetic and environmental factors other than H. pylori infection may explain the striking differences.…”