Duodenal bypass does not decrease glucose levels of lean individuals with gastric cancer submitted to partial or total gastrectomy

Abstract

-Change in glucose metabolism after bariatric operations may be credited to duodenal bypass. This study aims to evaluate the effect of duodenal bypass on glucose levels in lean individuals submitted to gastrectomy for gastric cancer. We reviewed 56 non-diabetic and 6 diabetic patients submitted to gastrectomy and Roux-en-Y for gastric cancer (partial gastrectomy in 66%/total gastrectomy in 34%). Glucose levels were not significantly altered after operation (P = 0.5). Diabetes control was improved in one patient with oral medication. In conclusion, duodenal bypass do not decrease glucose levels in lean individuals treated for gastric cancer.

Prospective Study of Self-Reported Diabetes and Risk of Upper Gastrointestinal Cancers

“…Interestingly, over the past two decades, bariatric surgeons have recognized that gastric bypass surgery, particularly total gastrectomy and to a lesser extent gastric binding, causes a durable improvement in Type 2 diabetes; remarkably, the normalization of glucose metabolism occurs within several weeks of surgery, long before any substantial weight loss occurs (29). This amelioration of diabetes has been shown consistently in obese patients (29-31) undergoing gastric bypass surgery and somewhat consistently in patients undergoing surgery for other indications, such as gastric cancer or gastric ulcer disease (32-34) In particular, bypass surgery alters the dietary exposure of the gastric cardia tissue. Therefore, the hormonal changes as a result of gastrectomy in bypass surgery may be implicated in changes in glucose metabolism (35-36).…”

Total gastrectomy improves glucose metabolism on gastric cancer patients: a nationwide population-based study

“…Furthermore, some patients developed alimentary hyperglycemia, which was associated with the decrease in insulin secretion [13], whereas DM did not resolve or improve even after TG for other patients [14].…”