Prevalence of HBV-genotypes in immigrants affected by HBV-related chronic active hepatitis

Palumbo, Emilio; Scotto, Gaetano; Faleo, Giuseppina; Cibelli, Donatella; Saracino, Annalisa; Angarano, Gioacchino

doi:10.1590/s0004-28032007000100012

Cited by 20 publications

(9 citation statements)

References 19 publications

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“…On the other hand, positivity to markers of active HBV infection (acute or chronic carrier) among immigrants was equivalent to that reported in Spain [11], but it was about tenfold higher than that described in the Italian population (10.4% vs. 1.5%) [12], and also in other studies conducted in Southern Italy [13,14]. In our country, HBsAg positivity had a consistent downward trend over the past 30 years as a result of the improvement in the social-economical conditions, the decreased intrafamilial spread, a better knowledge of both transmission routes and prevention measures.…”

Section: Discussionsupporting

confidence: 52%

Serological Pattern of Hepatitis B, C, and HIV Infections Among Immigrants in Sicily: Epidemiological Aspects and Implication on Public Health

et al. 2011

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The objective of this study was to describe the prevalence of Hepatitis B virus (HBV), Hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infections in a cohort of immigrants living in Palermo, Sicily. The study was carried out in the period May 2006-June 2010 and recruited a total of 393 patients (59.8% males-median age of 32.6 years). All patients were tested for serological markers of HBV, HCV, and HIV infection. One-hundred thirty-eight (35.1%) individuals did not show any HBV/HCV/HIV serological marker, while 186 (47.3%) were indicative of past or current HBV infection. A total of 42 (10.7%) subjects were HBsAg positive, 59 (15.0%) showed the serological profile "anti-HBc alone", and only 40 (10.1%) were anti-HBs alone. Overall, 22/393 (5.6%) immigrants were anti-HCV positive and 13/327 (4.0%) were infected with HIV. Findings from this study suggest that a suitable screening protocol for the viral blood/sexually transmissible diseases is recommended on entering Italy, and the adoption of health control strategies should also be considered to safeguard the health of the local population.

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Section: Discussionsupporting

confidence: 52%

Serological Pattern of Hepatitis B, C, and HIV Infections Among Immigrants in Sicily: Epidemiological Aspects and Implication on Public Health

et al. 2011

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“…This is the first study in Italy which evaluates the stage of HBV chronic hepatitis according to its viral genotype; previous studies had only showed the heterogeneity of the virus according to the subjects' geographical area [14, 15]. The results (HBsAg positive rate of 11.7%) reflect the actual prevalent migratory flow to Italy, especially in our geographic area, mostly represented by people coming from Africa [4].…”

Section: Discussionmentioning

confidence: 93%

Epidemiological and Clinical Features of Hepatitis B Virus Genotypes among Immigrants in Southern Italy

Scotto

Martinelli

Tullio

et al. 2010

Hepatitis Research and Treatment

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Background/aims. This study aims to determine the distribution and clinical features of HBV-genotypes in a population of immigrants affected by HBV-infection. Methods. Between 01/2003 and 03/2009, 1623 immigrants were tested for HBV-infection. Biochemical and virological activities were determined in HBsAg-positive patients; HBV-genotypes were determined, by the INNO-LiPA HBV Genotyping, in the subjects with HBV DNA detectable. In every patient we evaluated the stage and classified the infection as inactive carrier, mild or moderate/severe chronic hepatitis, cirrhosis, and/or HCC. Results. Among the tested subjects, 191 (11.7%) resulted HBsAg-positive, and in 144/191 (75.4%) serum HBV-DNA was detectable. The genotype distribution was as follows: 45,13% genotype E, 18,1% genotype D, 15,3% genotype B, 13,2% genotype C, 4,9% genotype A, 3,5% mixed genotypes (A–D). The evaluation of liver disease degree showed that 24.6% patients were inactive carriers of HBV infection, 19.4% presented a immunotolerance phase, 34.5% had mild chronic hepatitis, 13.6% had a moderate/severe chronic hepatitis, 6.3% had cirrhosis, and 1.6% presented HCC. Conclusions. Our study evidences a high prevalence of HBV-infection in immigrants, and the potentiality of migratory flow in the introduction of genotype non-D hepatitis B virus. The Hepatitis B virus genotypes presented significant differences in epidemiological and clinical characteristics.

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“…Indeed, the rate of the interviewed undocumented migrants and refugees who agreed to be screened seems a useful parameter to evaluate the effectiveness of the screening. The success of screening to identify serum markers of HBV, HCV or HIV infection in undocumented migrants or refugees varies from one study to another, mainly due to the different composition of the populations studied according to their place of origin, legal status, length of stay in the foreign country and the quality of the strategies used to improve the access of these vulnerable populations to a screening programme [22][23][24][25][26][27][28][29][30][31]. In our study, individuals who were HBsAg positive, HBsAg negative/anti-HBc positive, anti-HCV positive and anti-HIV positive were referred to a tertiary-level clinical centre to complete the diagnostic course and if necessary to receive therapeutic follow-up.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B virus, hepatitis C virus and human immunodeficiency virus infection in undocumented migrants and refugees in southern Italy, January 2012 to June 2013

Coppola

Alessio

Gualdieri³

et al. 2015

Eurosurveillance

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Screening of undocumented migrants or refugees for hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections has been offered free of charge and free from bureaucratic procedures since 2012 at four primary-level clinical centres in Naples and Caserta, Italy. Of 926 undocumented migrants and refugees visiting one of the primary-level clinical centres from January 2012 to June 2013, 882 (95%) were screened for hepatitis B surface antigen (HBsAg), total hepatitis B core antibody (anti-HBc) and antibodies against HCV and HIV. Of the 882 individuals enrolled, 78 (9%) were HBsAg positive, 35 (4%) anti-HCV positive and 11 (1%) anti-HIV positive (single infections); seven (1%) had more than one infection (three were HBsAg positive). Of the 801 HBsAg-negative patients, 373 (47%) were anti-HBc positive. The HBsAg-positivity rate was high (14%; 62/444) in individuals from sub-Saharan Africa and intermediate in those from eastern Europe (6%; 12/198), northern Africa (2%; 2/80) and Bangladesh, India, Pakistan and Sri Lanka (the 'India-Pakistan area') (3%; 4/126). Anti-HCV was detected in 9/126 (7%) individuals originating from the India-Pakistan area, in 12/198 (6%) from eastern Europe, in 17/444 (4%) from sub-Saharan and in 2/80 (2%) from northern Africa. The HBV, HCV and HIV infections in the undocumented migrants and refugees screened serve as a reminder to the Italian healthcare authorities to carry out extensive screening and educational programmes for these populations.

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Prevalence of HBV-genotypes in immigrants affected by HBV-related chronic active hepatitis

Cited by 20 publications

References 19 publications

Serological Pattern of Hepatitis B, C, and HIV Infections Among Immigrants in Sicily: Epidemiological Aspects and Implication on Public Health

Serological Pattern of Hepatitis B, C, and HIV Infections Among Immigrants in Sicily: Epidemiological Aspects and Implication on Public Health

Epidemiological and Clinical Features of Hepatitis B Virus Genotypes among Immigrants in Southern Italy

Hepatitis B virus, hepatitis C virus and human immunodeficiency virus infection in undocumented migrants and refugees in southern Italy, January 2012 to June 2013

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