Efeito do choque hipovolêmico na anastomose do intestino delgado de ratos

Brito, Marcus Vinicius Henriques; Koh, Ivan Hong Jun; Lamarão, Luciana Garcia; Damous, Sérgio Henrique Bastos

doi:10.1590/s0004-28032001000200007

Cited by 4 publications

(6 citation statements)

References 11 publications

(9 reference statements)

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“…Undeniably, it is important to know the risk factors of anastomotic dehiscence in this segment, however, there are few studies about anastomoses of the small intestine, despite its clinical and surgical importance. Moreover, as much as hemorrhagic shock is included among the risk factors for intestinal anastomoses 18 , its damage to the small bowel anastomoses has not been studied 6 . When the results of the groups regarding the gas insufflation test were analyzed, it was observed that in the group anastomosis + shock the rupture pressure of the bowel suture was significantly lower than in the group anastomosis at the 6th postoperative day (POD).…”

Section: Anastomotic Resistance Evaluationmentioning

confidence: 99%

“…However, there are both local and systemic factors that interfere in the healing process of intestinal anastomoses, related to the surgical technique, the use of pharmacological agents and general conditions of the patient, among which are included immunosuppression, infection, uremia, poor nutrition, anemia, elderly and anastomosis' vascularization [4][5][6] . The reduced blood flow as a result of shock is a leading cause of failure in the healing of intestinal anastomosis, once the healing process is directly related to perfusion in the suture line 9 .…”

Section: Introductionmentioning

confidence: 99%

“…In turn, tissue hypoperfusion leads to reduced oxygen availability to the cell, hypothermia, and metabolic acidosis 8 . Prolonged hypoxia, result of low blood flow conditions, has been shown to cause lesions in both the submucosa and in mucosal barrier 6 .…”

Section: Introductionmentioning

confidence: 99%

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Effect of hemorrhagic shock on intestinal anastomoses’ healing

Oliveira¹,

Cabral²,

Silva³

et al. 2015

J Surg Clin Res

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Background/Purpose: Hypovolemia and shock is increasingly frequent in the perioperative of intestinal anastomoses, especially due to abdominal trauma. The aim of this study is to evaluate the effects of hemorrhagic shock in the healing of intestinal anastomoses in rats. Methods: It was analyzed the shock interference on the strength of ileum anastomoses. Histologically, structural changes of the anastomotic segments were assessed by two pathologists. Data are given as mean ± SEM. The animals were randomly selected and assigned in two groups with six rats each: Group 1-rats with hypovolemic shock (shocked+enterectomy) treated with fresh whole blood. Group 2-rats not shocked, untreated + enterectomy. Results: The intestinal anastomosis bursting pressure of shock+enterectomy group rats was lower than in the unshocked+enterectomy group, and the difference was significant (p=0.001). In the hemorrhagic shock+enterectomy group rats the density of collagen and fibrous tissue was lower and inflammation/foreign body reaction was higher than in the unshocked+enterectomy group, featuring a more immature and deficient healing. Conclusion: In conclusion, the results show that the hypovolemic shock affects the ileum wound healing, causing a decrease in the bursting pressure (mmHg) of ileal anastomosis, leading to the fragility of the surgical wound.

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Section: Anastomotic Resistance Evaluationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of hemorrhagic shock on intestinal anastomoses’ healing

Oliveira¹,

Cabral²,

Silva³

et al. 2015

J Surg Clin Res

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“…Among them are the effects of substances on healing anastomosis phases, such as antibiotics (2) , hormonal and non-hormonal anti-inflamatories (3,4,5) , antioxidants (6) , anti-neoplasics (7) , imuno-suppressor drugs (8) , and hormones (9) . Other factors that interfere with intestinal anastomosis are also being studied, such as shock (10,11) , peritonite (12,13,14) , and adherences action (15,16) . In addition to these factors, local secondary hypoxy related to a decrease in sanguineous perfusion is an important agent that can cause anastamotic complications (10,17,18,19,20,21,22,23) .…”

Section: Introductionmentioning

confidence: 99%

Comparative study of the hyperbaric hyperoxygenation in ischemic colonic loops in rats

Rocha¹,

Coy²,

Góes³

et al. 2007

Acta Cir. Bras.

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Comparative study of the hyperbaric hyperoxygenation in ischemic colonic loops in rats -ORIGINAL ARTICLE Comparative study of the hyperbaric hyperoxygenation in ischemic colonic loops in rats 1Estudo comparativo da hiperoxigenação hiperbárica em alças cólicas isquêmicas em ratos ABSTRACT Purpose: To analyze and to evaluate the effect of the hyperbaric hyperoxygenation in the mechanical resistance of ischemic colon of rats. Methods: Eighty rats, distributed in four groups of 20 animals in each one, were used. In group 1 (G1), the control group, ischemia was not caused. Group 2 was submitted to the lesser degree of ischemia. Group 3 was submitted to the intermediate degree of ischemia. In group 4, a bigger degree of intestinal ischemia was provoked. Each group was divided in two sub-groups of ten animals each: with hyperbaric chamber (CC) and without hyperbaric chamber (SC). The animals of the four CC subgroups were placed in an experimental hyperbaric chamber in order to inhale oxygen at 100%, at two Absolute Atmospheres, for 120 minutes, for a four-day consecutive period. The animals of the four SC subgroups were kept in environment air during the five days of the experiment. All animals have been submitted to the mechanical study of the intestinal loop by the pressure test of the rupture by liquid distension. The euthanasia occurred in the fifth post-operative day. Results: Considering the ischemia factor, the four groups were different among them (p=0.0001). There was no statistical difference between subgroups CC and SC (p=0.3461). Conclusion: The hyperbaric oxygen-therapy did not present improvement on the induced ischemia in rats upright colic loop. Key words: Ischemia. Colon. Hyperbaric oxygenation. Rats. RESUMOObjetivo: Analisar e avaliar os efeitos da hiperoxigenação hiperbárica na resistência mecânica do cólon isquêmico de ratos. Métodos: Foram utilizados 80 ratos distribuídos em quatro grupos de 20 animais. No grupo 1, grupo controle, não se provocou isquemia. O grupo 2 foi submetido ao grau menor de isquemia. O grupo 3 foi submetido ao grau intermediário de isquemia. No grupo 4, provocou-se grau maior de isquemia intestinal. Cada grupo foi dividido em dois subgrupos de dez animais cada: com câmara hiperbárica (CC) e sem câmara hiperbárica (SC). Os animais dos quatro subgrupos CC foram colocados em uma câmara hiperbárica experimental para inalarem oxigênio a 100%, a duas atmosferas absolutas, durante 120 minutos, por quatro dias consecutivos. Os animais dos quatro subgrupos SC foram mantidos somente em ar ambiente. Todos animais foram submetidos ao estudo mecânico da alça intestinal pelo teste de pressão de ruptura pela distensão por líquido. A eutanásia ocorreu no quinto dia pós-operatório. Resultados: Os quatro grupos são diferentes entre si considerando o fator isquemia (p= 0.0001). Não houve diferença estatística entre os subgrupos CC e SC (p= 0.3461). Conclusão: A oxigenoterapia hiperbárica não apresentou melhora sobre a isquemia induzida em alça cólica íntegra de ratos. Descritores: Isquemia. Cól...

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“…Other factors that interfere with intestinal anastomosis are also being studied, such as shock (10,11) , peritonite (12,13,14) , and adherences action (15,16) . In addition to these factors, local secondary hypoxy related to a decrease in sanguineous perfusion is an important agent that can cause anastamotic complications (10,17,18,19,20,21,22,23) .…”

Section: Introductionmentioning

confidence: 99%