Importância da albumina sérica na avaliação nutricional e de atividade inflamatória em pacientes com doença de Crohn

Abstract

This study suggests that serum albumin concentration is a very sensitive marker of inflammatory activity and not good indicator of the nutritional status in Crohn's disease. It is necessary a suitable laboratorial parameter for routine nutrition assessment in patients with this inflammatory bowel disease.

Correlation Between Nutritional Status and Clinical Results in Patients Undergoing Spinal Surgery

“…Some authors affirm that albumin should not be used as a standalone criterion for the nutritional assessment of patients, and that it should be associated with other nutritional indicators, such as anthropometry and body composition. 21,22 This is due to their possible influence on the serum concentration of albumin, especially of changes in vascular permeability caused by the inflammatory process. Said situation generates a loss of albumin from the intravascular to the extravascular space and reduces their serum levels.…”

Análise descritiva dos perfis social, clínico, laboratorial e antropométrico de pacientes com doenças inflamatórias intestinais, internados no Hospital Universitário Clementino Fraga Filho, Rio de Janeiro

“…A apendicectomia havia sido realizada em três doentes (7%) antes da internação e deve ser ressaltado que, em alguns casos, a DC tem apresentação inicial que mimetiza a apendicite aguda, pelo acometimento inflamatório da região íleocecal (3) . O nível de albumina sérica freqüentemente correlacionado ao estado nutricional, também pode refletir reação de fase aguda mediada por citocinas durante um evento inflamatório (4,10) . A desnutrição e a hipoalbuminemia são achados relevantes nas DII, especialmente na DC (2) .…”

“…Embora de etiologia multifatorial, muitos pacientes internados com exacerbação aguda de sua doença apresentam desnutrição protéico-calórica (6,11,17,18) , hipoalbuminemia (4,7) e anemia (13,16,33) . Leucocitose, trombocitose, aumento nos níveis séricos de proteína C reativa e de velocidade de hemossedimentação (VHS) podem ser decorrentes de inflamação crônica (3,33) .…”

Effects of oxidative stress on the virulence profile of Prevotella intermedia during experimental infection in gnotobiotic mice

“…Albumin is a hepatic protein involved in homeostasis of blood osmotic pressure. A decrease in albumin levels leads to problems in the abdomen (ascite) and in the lungs (pulmonary oedema) (Cabral et al, 2001;Mello et al, 2004;Orhue et al, 2005). Similarly to human beings, alterations in albumin and alkaline phosphatase levels observed in animals challenged with the aero strain could be the results of inflammatory reactions (Fey & Gauldie, 1990;Cabral et al, 2001).…”

“…A decrease in albumin levels leads to problems in the abdomen (ascite) and in the lungs (pulmonary oedema) (Cabral et al, 2001;Mello et al, 2004;Orhue et al, 2005). Similarly to human beings, alterations in albumin and alkaline phosphatase levels observed in animals challenged with the aero strain could be the results of inflammatory reactions (Fey & Gauldie, 1990;Cabral et al, 2001). Spleen hypertrophy could be related to the haemorrhagic process as well as to immunosuppression due to degeneration of lymphoid tissue (Casadevall & Pirofski, 1999;Papet et al, 2003).…”