Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract

Ribeiro, Ulysses; Ivan, Cristina; Safatle‐Ribeiro, Adriana Vaz; Zilberstein, Bruno; Pinotti, H W

doi:10.1590/s0004-28031999000400006

Cited by 13 publications

(16 citation statements)

References 24 publications

(52 reference statements)

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“…Alcohol drinking and smoking are carcinogens acting synergistically in the development of head and neck primary neoplasms 4,20 -23 and also are important risk factors in developing a second primary neoplasia (esophageal) in patients with squamous cell carcinoma. 12,16,24 Alcohol and tobacco are two well known major risk factors for cancer of the esophagus. 4,5,7,16,21-23,25 -36 In the present study, we verified a higher frequency of second esophageal primary tumor and alcohol drinking.…”

Section: Discussionmentioning

confidence: 99%

Dietary habits, ethanol and tobacco consumption as predictive factors in the development of esophageal carcinoma in patients with head and neck neoplasms

et al. 2008

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Patients with primary head and neck cancers have a higher risk of developing esophageal cancer. The aim of this study was to investigate esophageal cancer prevalence, its risk factors (ethanol and tobacco consumption) and dietary habits in patients with head and neck cancer. Three hundred and twenty-six adults with primary head and neck cancer were followed by a retrospective observational study in a general university hospital in Sao Paulo, Brazil. Flexible videoendoscopy with lugol chromoscopy was the method used to investigate esophageal cancer prevalence. All subjects were interviewed face-to-face, revealing detailed information about their tobacco and alcohol use, as well as their dietary habits. Thirty-six patients with esophageal cancer were diagnosed and the overall prevalence rate was 11.04%. Patients who developed second esophageal tumors had the following characteristics: earlier age of initial ethanol consumption (P < 0.05), longer duration period of ethanol consumption (P < 0.05) and higher weekly consumption rate (P < 0.05). There was an increased risk of esophageal carcinoma in those patients who both smoked and drank (P < 0.05). There was no association between carcinoma of the esophagus and dietary habits in patients who developed esophageal neoplasms, compared with those who did not. Prevalence rate of esophageal neoplasms was 11.04% in patients with head and neck carcinoma, whose ethanol consumption was associated with esophageal cancer. There was an increased risk between ethanol and tobacco consumption and esophageal carcinoma development. On the other hand, there was no association regarding dietary habits between patients who developed esophageal cancer and those who did not.

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Section: Discussionmentioning

confidence: 99%

Dietary habits, ethanol and tobacco consumption as predictive factors in the development of esophageal carcinoma in patients with head and neck neoplasms

et al. 2008

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“…Secondary malignancies that occur synchronously are not rare in patients with EC. It was reported that up to 5% of patients had additional cancer of the stomach, the lung or the head and neck [12][13][14] ( Table 3). The false positive findings on FDG-PET scans are mostly caused by the fact that FDG illustrates glucose metabolism and is, therefore, not tumour specific.…”

Section: Discussionmentioning

confidence: 99%

Impact of FDG-PET for staging of oesophageal cancer

Imdahl

Hentschel

Kleimaier

et al. 2004

Langenbecks Arch Surg

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“…After 2 days, nonadherent spleen cells were removed, and plastic adherents cells were maintained in culture with 30 ml of complete RPMI medium supplemented with r‐IL2 for 5 more days. A‐NK cells were harvested after a short treatment with 0.02% EDTA [14, 17].…”

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confidence: 99%

Interleukin‐2‐Activated Natural Killer Cells May Have a Direct Role in the Control of Leishmania (Leishmania) amazonensis Promastigote and Macrophage Infection

et al. 2005

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To study the role of Natural Killer (NK) cells in Leishmania infection, peritoneal macrophages from BALB/c mice were infected with Leishmania (Leishmania) amazonensis promastigotes and incubated with interleukin-2 (IL-2)-activated NK (A-NK) cells at different ratios of A-NK cells to infected macrophages (5:1, 1:1, 0.2:1). The A-NK cells were added either together with the parasites (0-h group) or 24 h later (24-h group). Morphological studies of the cultures revealed predominance of parasitic debris within macrophages that were in close contact with A-NK cells and the decrease in parasite recovery was directly proportional to the A-NK cell concentration used. Interferon-(IFN-) and IL-12 were detected in the supernatant at levels proportional to the A-NK cell concentration used. No significant difference was observed between the groups with respect to NO levels in the culture supernatant. When A-NK cells were added directly to the L. (L.) amazonensis promastigote cultures, the parasite recovery decreased proportional to the number of A-NK cells added. In vivo studies demonstrated smaller lesion sizes in animals inoculated with both parasites and A-NK cells compared with parasites alone. Histopathology of the skin lesions from animals receiving A-NK cells together with the parasites showed moderate parasitism and a nodular inflammatory infiltrate formed by mononuclear cells and a few vacuolized macrophages. In contrast, animals inoculated only with the parasites showed a highly parasitized dermis with infiltration of intensely vacuolized macrophages. These results demonstrate the role of A-NK cells in parasite lysis and in resistance of macrophages to L. (L.) amazonensis in the early phase of infection.

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Squamous cell carcinoma of the esophagus and multiple primary tumors of the upper aerodigestive tract

Abstract: -Squamous cell carcinoma of the esophagus is frequently associated with other

Cited by 13 publications

References 24 publications

Dietary habits, ethanol and tobacco consumption as predictive factors in the development of esophageal carcinoma in patients with head and neck neoplasms

Dietary habits, ethanol and tobacco consumption as predictive factors in the development of esophageal carcinoma in patients with head and neck neoplasms

Impact of FDG-PET for staging of oesophageal cancer

Interleukin‐2‐Activated Natural Killer Cells May Have a Direct Role in the Control of Leishmania (Leishmania) amazonensis Promastigote and Macrophage Infection

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