Clinical Evaluation and Pattern of Symptoms in Colorectal Cancer Patients

Abstract

BACKGROUND: Colorectal cancer is the third most common type of cancer in the world and the increased survival of the colorectal cancer population is very significant. Thus, it becomes relevant to study the symptoms associated with the progression of the disease and treatment, for proper clinical management. OBJECTIVE: To describe the clinical and epidemiological profile of colorectal cancer patients and to identify the most prevalent signs and symptoms patterns. METHODS: Cross-sectional study evaluating the prevalence of symptoms in 348 colorectal cancer patients admitted to a referral oncology hospital. We applied MSAS-BR scale and, through factor analysis with principal componente analysys, we performed the grouping of symptoms. RESULTS: There was a predominance of men, aged 60 years or older, married, white, with high school, moderately differentiated tumor, stage III/IV disease, colon cancer and no distant metastasis. The most prevalent symptoms were weight loss (67.53%) and the least prevalent were mouth sores (2.01%). The groupings of symptoms established were “fatigue and psychic symptoms”, “gastrointestinal symptoms”, “self-perceptive symptoms” and “general symptoms”, which described 80% of the symptoms presented. CONCLUSION: We evidenced the importance of identifying these symptoms clusters in order to improve strategies for clinical management in patients with colorectal cancer.

Efeitos do isolamento social na saúde mental de mulheres idosas

“…O CCR se inicia como um tumor em desenvolvimento na parede interna do cólon ou do reto, onde as células dessa região acumulam alterações epigenéticas de manifestação lenta e gradual, com tempo de desenvolvimento entre 10 a 20 anos. A sintomatologia pode variar de acordo com a faixa etária, com emagrecimento, dor, disfunção no trato urinário, úlceras orais e ansiedade (ARAN et al, 2016;MELLO et al, 2020;TESTA;PELOSI;CASTELLI, 2018).…”

A participação dos canais de potássio Kv11.1 na progressão do câncer colorretal: uma revisão integrativa de literatura / Kv11.1 potassium channels participation in colorectal cancer progression: an integrative literature review

“…O câncer colorretal é provocado devido ao acúmulo de mutações no material genético geradas ao decorrer da vida, sendo que existem muitas evidências científicas que apontam para a dieta, bem como a ausência da prática de exercícios físicos, como fatores relacionados com o desenvolvimento deste tipo de câncer (MELLO et al, 2020). Além disso, segundo Fiore e colaboradores (2013, p. 583), "a progressão do CCR está associada com fatores genéticos, como por exemplo, a ausência dos genes supressores tumorais e de mecanismos de reparo do genoma, bem como a ativação de oncogenes".…”

Application of rational emotive behavior therapy in patients with colorectal cancer undergoing adjuvant chemotherapy

“…Symptoms such as gastrointestinal dysfunction, fatigue, and peripheral neuropathy were commonly reported, and anxiety, depression, and other adverse emotions increase stress and severity of the symptoms. Moreover, many studies [ 4 , 5 ] have shown that anxiety and depression are closely related to the symptoms, and long-term negative emotions directly affect sleep quality. These problems will directly or indirectly affect the treatment and prognosis of patients with CRC [ 6 ] and lead to a reduction in quality of life, eventually increasing the risk of suicide [ 7 ].…”