2017
DOI: 10.1590/s0004-2803.2017v54n1-01
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Abstract: -Background -Most prevalent esophageal neoplasm is squamous cell carcinoma and adenocarcinoma. Other tumors are uncommon and poorly studied. Primary neuroendocrine esophageal neoplasm is a rare carcinoma and most of its therapy management is based on lung neuroendocrine studies. Neuroendocrine tumors can be clustered in the following subtypes: high grade (small cell carcinoma or large cell carcinoma) and low grade (carcinoids). Objective -The present study aims to assess clinical and pathological neuroendocrin… Show more

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Cited by 28 publications
(19 citation statements)
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“…They are a heterogeneous group of tumors with biological behaviors that include slow growth, inertia, low-grade malignancy, significant malignancy, high invasiveness, and metastasis. [1][2][3] Some types of NENs have a genetic predisposition and may be associated with genetic mutations, such as multiple endocrine neoplasia type 1 and 2 (MEN-1 and MEN-2), familial paraganglioma syndrome, von Hippel-Lindau syndrome, and Carney-Stratakis syndrome. 4 NENs are divided into two categories according to the clinical symptoms and levels of hormone secretion: functional and nonfunctional.…”
Section: Introductionmentioning
confidence: 99%
“…They are a heterogeneous group of tumors with biological behaviors that include slow growth, inertia, low-grade malignancy, significant malignancy, high invasiveness, and metastasis. [1][2][3] Some types of NENs have a genetic predisposition and may be associated with genetic mutations, such as multiple endocrine neoplasia type 1 and 2 (MEN-1 and MEN-2), familial paraganglioma syndrome, von Hippel-Lindau syndrome, and Carney-Stratakis syndrome. 4 NENs are divided into two categories according to the clinical symptoms and levels of hormone secretion: functional and nonfunctional.…”
Section: Introductionmentioning
confidence: 99%
“…This study reported a number of characteristics of oesophageal carcinoid that were ambiguous in reference books and sources. A review in early 2017 included a total of 1574 oesophageal cancers; 14 (0.89%) were cases of neuroendocrine neoplasm and 1/14 (7.1%) had oesophageal carcinoid [ 2 ]. Hoang et al [ 6 ] included 13 patients who were diagnosed as upper gastrointestinal carcinoid tumours, of which just 1 (7.7%) patient had oesophageal carcinoid, and in another study this figure was 7.9% [ 22 ].…”
Section: Discussionmentioning
confidence: 99%
“…Endocrine tumours of the gastrointestinal tract, which are known as carcinoids, herein collectively termed neuroendocrine tumours (NETs), originate from the diffuse neuroendocrine cell system [ 1 ]. Typical carcinoid, atypical carcinoid, small cell neuroendocrine carcinoma, and large cell neuroendocrine carcinoma are subgroups of neuroendocrine tumours [ 2 ]. The traditional term of carcinoid is not adequate to cover all NETs [ 3 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, atypical esophageal NETs (classified as large cell esophageal carcinoma or small cell esophageal carcinoma) may present at late stages with large fungating masses. These lesions have high mortality within a year despite surgical resection and subsequent chemotherapy[12-14]. …”
Section: Esophagusmentioning
confidence: 99%