2017
DOI: 10.1590/s0004-2803.201700000-41
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Abstract: -Background -Crohn's disease and ulcerative colitis are chronic inflammatory bowel diseases. In such pathologies, there is an increased production of alpha tumor necrosis factor (TNF-α). Patients, in whom the conventional immunosuppressant treatment fails, require the use of immunobiological therapy, such as anti-TNF-α, a monoclonal antibody. infliximab is an anti-TNF-α drug, a chimerical immunoglobulin, with a murine component, which is responsible for the generation of immunogenicity against the drug and for… Show more

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Cited by 10 publications
(10 citation statements)
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“…As the blood samples necessary for the trough level tests are collected immediately before the infusion, it means that these results are not going to be useful until the next infusion. As a consequence, ELISA IFX levels tests do not allow immediate dose escalation or de-escalation and may generate difficulties in implementing TDM in a hospital or in an infusion unit (8,(11)(12)(13)17) . Despite all these considerations with the ELISA, they still constitute the standard method in which TDM is based.…”
Section: Resultsmentioning
confidence: 99%
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“…As the blood samples necessary for the trough level tests are collected immediately before the infusion, it means that these results are not going to be useful until the next infusion. As a consequence, ELISA IFX levels tests do not allow immediate dose escalation or de-escalation and may generate difficulties in implementing TDM in a hospital or in an infusion unit (8,(11)(12)(13)17) . Despite all these considerations with the ELISA, they still constitute the standard method in which TDM is based.…”
Section: Resultsmentioning
confidence: 99%
“…So far, few studies were published reporting the use of TDM in Latin America, and they did not compare different assays as our study. They were just case series with a single method being used (12,13) .…”
Section: Resultsmentioning
confidence: 99%
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“…There are few studies concerning biological drug monitoring in the Brazilian inflammatory bowel disease (IBD) patient population 10. Therefore, our aim was to analyze the serum level of IFX and the detection of ATIs in a prospective patient cohort at a southeastern Brazilian tertiary center and to correlate these measurements with disease activity.…”
Section: Introductionmentioning
confidence: 99%