FLAVONOIDS AND ANTI-OXIDANT ACTIVITY MEDIATED GASTROPROTECTIVE ACTION OF LEATHERY MURDAH, TERMINALIA CORIACEA (ROXB.) WIGHT &amp; ARN. LEAF METHANOLIC EXTRACT IN RATS

Khan, Mohammed Safwan Ali; Nazan, Shaaz; Jais, Abdul Manan Mat

doi:10.1590/s0004-2803.201700000-21

Cited by 20 publications

(14 citation statements)

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“…This biological action was found to be dose dependent and as effective as the positive control (aspirin). The therapeutic potential of the extract could be attributed to the antioxidant activity and its flavonoid content (apigenin, kaempferol, luteolin, myricetin, quercetin, and rutin) [6]. Flavonoids have been reported to possess a wide range of biological actions [20].…”

Section: Discussionmentioning

confidence: 99%

“…This directly diminishes the release of arachidonic acid by neutrophils and other immune cells [30]. The antioxidant and anti-inflammatory properties of the leaf extract give further insights into its healing effects on gastric ulcer [6] and wounds.…”

Section: Discussionmentioning

confidence: 99%

“…The reported maximum oral safe dose is 20,000 mg/kg [6]. Three test doses 125, 250, and 500 mg/kg were selected for the assessment of anti-inflammatory activity, with the highest test dose being 1/40th of the maximum oral safe dose.…”

Section: Methodsmentioning

confidence: 99%

“…Three test doses 125, 250, and 500 mg/kg were selected for the assessment of anti-inflammatory activity, with the highest test dose being 1/40th of the maximum oral safe dose. These 3 doses were used previously for the evaluation of antinociceptive [3], anti-epileptic [5] and gastroprotective activities [6]. …”

Section: Methodsmentioning

confidence: 99%

“…Recent pharmacological investigations on the methanolic extract of T. coriacea leaves revealed antinociceptive [3], wound healing [4], anticonvulsant [5], anti-ulcer [6], and hepatoprotective potentials [7]. Phytochemical studies had revealed the presence of bioactive compounds such as flavonoids like apigenin, kaempferol, luteolin, myricetin, quercetin, ru tin [6], 1H-inden-1-one,2,3-dihydro-3,3,5,6,-tetramethyl; levoglucosan; neophytadiene; phytol; hexadecanoic acid; n-hexadecanoic acid; stigmasterol; ß-sitosterol [8]; betulic acid, arjunic acid, arjunolic acid, arjunetin, ellagic acid [9], gallic acid, procyanidin B 1 , B 2 , and B 3 , resveratrol, tyrosine [10]; raffinose; 1,2-benzene dicarboxylic acid; undecanoic acid; (2-propyl-1,3-dioxolan-2-yl)acetic acid; 2,2-dimethyl propane, and octadecatrienoic acid [11]. Based on the rich phytochemical nature and traditional use in inflammation, the present study was conducted to evaluate anti-inflammatory activity of methanolic extract of T. coriacea in acute and chronic inflammatory models.…”

Section: Introductionmentioning

confidence: 99%

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Methanolic Extract of Leathery Murdah, Terminalia coriacea (Roxb.) Wight and Arn. Leaves Exhibits Anti-Inflammatory Activity in Acute and Chronic Models

et al. 2018

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Objective: The aim of the present study was to evaluate anti-inflammatory activity of methanolic extract of Terminalia coriacea. Materials and Methods: A methanolic extract of T. coriacea leaves was studied in albino Wistar rats with carrageenan-induced paw edema, an acute model, and cotton pellet-induced granuloma, a chronic model, at 3 oral test doses (125, 250, and 500 mg/kg). Aspirin 100 mg/kg was used as a positive control. Paw volume and wet and dry weights of cotton pellets were determined. The data were analyzed by one-way ANOVA followed by Dunnett’s multiple comparison test. Results: The test extract at doses of 125 and 250 mg/kg decreased paw volume and wet and dry weights of cotton pellets. The highest test dose (500 mg/kg) displayed a response comparable to that of the standard drug (p < 0.01) on paw volume. The extract produced similar (p < 0.05) decrease in wet weight of the cotton pellet at 125 and 250 mg/kg, whereas the effect of 500 mg/kg of the extract was comparable to that of aspirin 100 mg/kg (p < 0.01). The extract of T. coriacea at 500 mg/kg induced the most significant (p < 0.01) effect on wet weight of granulomatous tissue. Conclusion: The methanolic extract of T. coriacea leaves successfully decreased paw edema as well as dry and wet weights of granulomatous tissue in both acute and chronic inflammatory models thus confirming the anti- edematogenic, antitransudative, and antiproliferative properties of T. coriacea.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Methanolic Extract of Leathery Murdah, Terminalia coriacea (Roxb.) Wight and Arn. Leaves Exhibits Anti-Inflammatory Activity in Acute and Chronic Models

et al. 2018

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Skullcapflavone I has a potent anti‐pancreatic cancer activity by targeting miR‐23a

Cui

Wáng

et al. 2020

BioFactors

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Baicalein has been widely studied and showed a potent activity against pancreatic cancer in both in vivo and in vitro studies. Little is known regarding the effects of Skullcapflavone I (SFI), despite they have similar structures. So, this study was to explore the function of SFI on human pancreatic cancer. Panc-1 cells were transfected with miR-23a precursor, miR-23a inhibitor or the negative controls, and subsequently treated by SFI. Cell viability, Bromodeoxyuridine (BrdU)-positive cell rate, apoptosis, migration, invasion, and related protein expression were assessed by utilizing Cell Counting Kit-8 (CCK-8), BrdU staining, apoptosis assessment, transwell assay, and western blot. SFI significantly reduced the proliferation, migration, and invasion, as well as induced apoptosis of Panc-1 cells. MiR-23a, miR-21, and miR-155 were lowly expressed while miR-145 and miR-146a were highly expressed in SFI-treated cell. Of note, the antitumor effects of SFI were promoted by miR-23a suppression whereas attenuated by miR-23a overexpression. JAK/STAT and MAPK pathways were inhibited by SFI. Also, the pathway inhibition in SFI-treated cells was reversed by miR-23a overexpression. SFI might be a promising anti-pancreatic cancer agent by inhibiting cancer cells growth and motility. The anticancer activities of SFI might be through downregulation of miR-23a, as well as inhibition of JAK/STAT and MAPK pathways. K E Y W O R D S miR-23a, Panc-1 cell, pancreatic cancer, skullcapflavone I 1 | INTRODUCTION Pancreatic cancer, as one of the deadly diseases, has a 5-year survival rate of <7%. 1 As the rate of obesity, hyperlipidemia, diabetes, and chronic pancreatitis has exploded, the prevalence of pancreatic cancer is rising. In 2012, approximately 338,000 people had pancreatic cancer worldwide. 2 Pancreatic cancer is difficult to be diagnosed in an early stage since no symptoms usually appear; thus, a majority of patients present with

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Gastroprotective effect of ethyl acetate extract from Avicennia schaueriana Stapf & Leechman and underlying mechanisms

Barbosa

Santana

Leite

et al. 2019

Biomedicine & Pharmacotherapy

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FLAVONOIDS AND ANTI-OXIDANT ACTIVITY MEDIATED GASTROPROTECTIVE ACTION OF LEATHERY MURDAH, TERMINALIA CORIACEA (ROXB.) WIGHT & ARN. LEAF METHANOLIC EXTRACT IN RATS

Cited by 20 publications

References 40 publications

Methanolic Extract of Leathery Murdah, <b><i>Terminalia coriacea</i></b> (Roxb.) Wight and Arn. Leaves Exhibits Anti-Inflammatory Activity in Acute and Chronic Models

Methanolic Extract of Leathery Murdah, <b><i>Terminalia coriacea</i></b> (Roxb.) Wight and Arn. Leaves Exhibits Anti-Inflammatory Activity in Acute and Chronic Models

Skullcapflavone I has a potent anti‐pancreatic cancer activity by targeting miR‐23a

Gastroprotective effect of ethyl acetate extract from Avicennia schaueriana Stapf & Leechman and underlying mechanisms

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