Inflammatory Bowel Disease: Outpatient Treatment Profile

Santos, Roseane Maria Maia; Carvalho, Ana Teresa Pugas; Silva, Kelly dos Santos; Sá, Selma Petra Chaves; Santos, Aparecida Helena Dos; Sandinha, Millene Ramos

doi:10.1590/s0004-2803.201700000-01

Cited by 12 publications

(12 citation statements)

References 10 publications

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“…In 11 studies, the greatest proportion of patients had extensive (pancolitis). 10 , 17 , 21 – 24 , 27 – 30 , 33 In a nationwide study in Mexico, which separated UC extension by age group, pancolitis was the most frequent extension of UC in children (64.4%), adult (62.2%) and elderly (57.7%) patients; distal/proctosigmoiditis was the second most frequent extension in children (22.2%), adult (24.8%) and elderly (26.8%) patients; and left-sided colitis was the least frequent extension in children (13.3%), adult (13.0%) and elderly (15.6%) patients. 27 , 28 In line with this, the highest proportion of patients (43%) had pancolitis in a study in Argentina.…”

Section: Resultsmentioning

confidence: 99%

Review of the epidemiology and burden of ulcerative colitis in Latin America

Kotze

Steinwurz

Francisconi

et al. 2020

Therap Adv Gastroenterol

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The incidence and prevalence of ulcerative colitis (UC) has been reported to be rising in newly industrialised regions, such as Latin America. Here, we review data from published studies reporting demographics and clinical aspects of UC in Latin America to further understand epidemiology and disease burden. The incidence and prevalence of UC in Latin America varied between regions and studies, ranging between 0.04 to 8.00/100,000 and 0.23 to 76.1/100,000, respectively, and generally increased over the period from 1986 to 2015. The majority of patients with UC were female (53.6–72.6%) and urban residents (77.8–97.4%). Extraintestinal manifestations were reported in approximately 26–89.4% of patients. Use of biologic therapies was generally low (0.8–16.2%), with the exception of Mato Grosso do Sul, Brazil, with a greater proportion of patients tending to receive 5-aminosalicylates, immunosuppressants or corticosteroids; colectomy rates varied between studies (1.5–22%). A high proportion of patients had moderate to severe UC (45.9–73.0%) and, in 11 of 19 studies, the greatest proportion of patients had extensive disease (pancolitis). Colorectal cancer (0–1.7%) and mortality rates (0–7.6%) were low. This evaluation of published studies may influence therapeutic approaches and the development of strategies to improve healthcare access and patient outcomes, although further high-quality studies are required in patients with UC in Latin America.

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Section: Resultsmentioning

confidence: 99%

Review of the epidemiology and burden of ulcerative colitis in Latin America

Kotze

Steinwurz

Francisconi

et al. 2020

Therap Adv Gastroenterol

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“…[50]One study found a higher prevalence of left-sided colitis, higher mortality, and higher usage of biological agents in Mexican population than in Mexican-American population, supporting the role of environmental factors on clinical characteristics of IBD. [24] The larger case-series in LAC Countries are from 1946 to date are from Argentina [14,51,52], Barbados [13], Brazil [14,[53][54][55][56][57][58][59][60][61][62][63][64][65], Chile [66][67][68], Cuba [69], Peru [70,71], Puerto Rico [72][73][74][75] and Uruguay. [76][77][78] Most CD localizations were ileal-colonic and CD behavior was mostly inflammatory, followed by penetrant or stenotic.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study

et al. 2020

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Background and aims Ulcerative Colitis (UC) and Crohn's Disease (CD) have a major impact on quality of life and medical costs. The aim of the study was to estimate the prevalence, incidence and clinical phenotypes of Inflammatory Bowel Disease (IBD) cases in Mexico and Colombia. Methods We analyzed official administrative and health databases, used mathematical modelling to estimate the incidence and complete prevalence, and performed a case-series of IBD patients at a referral center both in Mexico and Colombia. Results The age-adjusted complete prevalence of UC per 100,000 inhabitants for 2015/2016 ranged from 15.65 to 71.19 in Mexico and from 27.40 to 69.97 in Colombia depending on the model considered. The prevalence of CD per 100,000 inhabitants in Mexico ranged from 15.45 to 18.08 and from 16.75 to 18.43 in Colombia. In Mexico, the age-adjusted incidence of UC per 100,000 inhabitants per year ranged from 0.90 to 2.30, and from 0.55 to 2.33 in Colombia. The incidence for CD in Mexico ranged from 0.35 to 0.66 whereas in Colombia, the age-adjusted incidence of CD ranged from 0.30 to 0.57. The case-series included 200 IBD patients from Mexico and 204 patients from Colombia.

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“…Complementarily data have shown a higher prevalence among youngsters in recent years 17–25. Unfortunately, in Brazil, epidemiological data are scarce and generally refer to the public health system, based on hospitalization records or records of patients who purchase high-cost medications through the government 26–31. Although the main symptoms of the diseases are well-known in the literature, in Brazil up until now, there have been no studies on the main clinical signs and symptoms that could lead to investigation and diagnosis from the time of the onset of the symptoms to a defined diagnosis; in what way these diseases are present; which is the most frequent behavior; the associations of risk factors; what medical approaches have been attempted, and the incidence of complications over time.…”

Section: Introductionmentioning

confidence: 99%

<p>Inflammatory bowel diseases: time of diagnosis, environmental factors, clinical course, and management – a follow-up study in a private inflammatory bowel disease center (2003–2017)</p>

DB¹,

Oliveira²,

MS³

2019

JIR

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Background The governmental program of Brazilian Unified National Health System has already published studies on the incidence of inflammatory bowel diseases (IBD), but up until now, there have been no epidemiological studies in private centers in Brazil. However, these diseases tend to affect people from a higher socioeconomic class, mainly in the capital of MS state that has the third highest GDP in Brazil. Objectives The aim was to analyze an observational, descriptive study of an IBD database in a private center including: the side, behavior of the disease and medical management, the association of extra-intestinal manifestations, and the main clinical symptoms which led to the investigation and diagnosis of IBD. Patients and methods A cohort study was developed in which data of all patients with IBD were analyzed with SPSS software in a constructed electronic database. Results Of 329 patients, 212 (64.4%) had Crohn’s disease (CD) and 117 (35.6%) had ulcerative colitis (UC). Average age at diagnosis of CD was 36.19 (±14.33) and of UC was 41.61 (±15.37). An amount of 50.05% of the patients with CD and 72.7% ( P <0.001) with UC were female. We have observed that concerning the first symptoms, diahrrea and blood feces corresponded to 70% in UC while in CD 50% of the patients presented diahrrea with blood feces, loss of weight corresponded to 50% and only diahrrea 25%. ( P <0.001). Anti-TNFs corresponded to 56.2% being more frequent in CD 0.001%. CD patients used biologic therapy and antibiotics more frequently than those with UC. In conclusion, IBD is also frequent in private health care centers in Brazil; women are most affected. Symptoms such as diarrhea and bleeding, as well as diarrhea and weight loss, must be taken as warning signs to investigate for inflammatory disease. The use of biologic therapies is frequent in referral centers when patients have severe disease.

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Inflammatory Bowel Disease: Outpatient Treatment Profile

Cited by 12 publications

References 10 publications

Review of the epidemiology and burden of ulcerative colitis in Latin America

Review of the epidemiology and burden of ulcerative colitis in Latin America

Epidemiology of inflammatory bowel disease in Mexico and Colombia: Analysis of health databases, mathematical modelling and a case-series study

<p>Inflammatory bowel diseases: time of diagnosis, environmental factors, clinical course, and management – a follow-up study in a private inflammatory bowel disease center (2003–2017)</p>

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