Nerve fiber layer in glaucomatous hemifield loss: a case-control study with time- and spectral-domain optical coherence tomography

Reis, Arlete Barbosa dos; Vidal, Kallene Summer Moreira; Kreuz, André Carvalho; Monteiro, Mário Luiz Ribeiro; Nicolela, Marcelo T.; Malta, Roberto Freire Santiago

doi:10.1590/s0004-27492012000100011

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…On the contrary, SD-OCT technology has supposed a revolution regarding the speed imaging acquisition and a higher axial resolution of these images, hence improving the structural analysis of retinal layers including ONH. Nevertheless, it is still controversial whether SD-OCT has improved diagnostic ability compared with the previous generation of OCT in glaucoma patients 28,49…”

Section: Discussionmentioning

confidence: 99%

Development of a new algorithm based on FDT Matrix perimetry and SD-OCT to improve early glaucoma detection in primary care

Morejon

Mayo-Íscar

Martín

et al. 2018

OPTH

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PurposeThe purpose of this study was to develop an objective algorithm to discriminate the earliest stages of glaucoma using frequency doubling technology (FDT) Matrix perimetry and spectral domain-optical coherence tomography (OCT) technology to improve primary care detection.Materials and methodsThree hundred six eyes (mean age 58.67±15.12) from 161 patients were included and classified in the following three groups: 101 nonglaucoma (GI-NG), 100 glaucoma suspect (GII-SG), and 105 open-angle glaucoma (GIII-OAG). All participants underwent a visual field exploration using the Humphrey Matrix visual field instrument and retinal nerve fiber layer evaluation using the Topcon 3D OCT-2000. Pattern deviation plot was divided into 19 areas and five aggrupation or quadrants and ranked with a value between 0 and 4 according to its likelihood of normality, and differences among three groups were analyzed. Principal component analysis (PCA) was also used to extract the most notable features of FDT and OCT, and a logistic regression analysis was applied to obtain the classification rules.ResultsOnly area numbers 7 and 12 and the central zone of FDT Matrix showed statistical differences (P<0.05) between GI-NG and GII-SG. The classification rules were estimated by the four PCA obtained from FDT Matrix and 3D OCT-2000 in a separate and combined use. Area under the receiver operating characteristic curve was 78.88% with FDT-PCA, 82.09% with OCT-PCA, and 94.27% with combined use of FDT and OCT-PCA to discriminate GI-NG and GII-SG.ConclusionThe predictive rules based on FDT-PCA or OCT-PCA provide a high sensitivity and specificity to detect the earliest stages of glaucoma and even better in combined use. These predictive rules may help the future development of software for FDT Matrix perimetry and 3D OCT-2000, which will greatly improve their diagnostic ability, making them useful in daily practice in a primary care setting.

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Section: Discussionmentioning

confidence: 99%

Development of a new algorithm based on FDT Matrix perimetry and SD-OCT to improve early glaucoma detection in primary care

Morejon

Mayo-Íscar

Martín

et al. 2018

OPTH

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“…The main characteristic of the early damage caused by glaucoma is its asymmetry with respect to the horizontal meridian. For this reason, several methods of investigation have been developed in order to assess the asymmetry of the upper and lower sectors of the nerve fiber layer, 60 , 61 of the neuroretinal rim, 62 , 63 and macular thickness. 64 , 65 …”

Section: Discussionmentioning

confidence: 99%

Hemifield pattern electroretinogram in ocular hypertension: comparison with frequency doubling technology and optical coherence tomography to detect early optic neuropathy

Finzi¹,

Strobbe²,

Tassi³

et al. 2014

OPTH

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BackgroundTo assess the sensitivity and specificity of hemifield pattern electroretinogram (HF-PERG) for detecting early retinal ganglion cell (RGC) damage in ocular hypertensive (OH) patients.MethodsFifty-two OH patients (mean age 56±9.6 years) with an intraocular pressure (IOP) .21 mmHg were assessed. All subjects underwent HF-PERG, optical coherence tomography (OCT), and frequency doubling technology (FDT) visual field.ResultsOH patients showed a significant increase of peak-time of the N95 (P=0.027) compared to controls. The amplitude of the N95 of the lower and upper HF-PERG showed significant differences (P=0.037 and P=0.023, respectively) between the two groups. A significant intraocular (P=0.006) and interocular (P=0.018) asymmetry of N95 amplitude was found. Receiver operating characteristic (ROC) curve analysis revealed a sensitivity of 93% for the N95 of the lower HF-PERG, whereas full-field pattern electroretinogram (PERG) N95 peak-time had a sensitivity of 88%. In OH patients, we found a thinning of OCT - retinal nerve fiber layer (RNFL), especially in the superior and inferior quadrant, although not statistically significant, and a significantly higher FDT pattern standard deviation (FDT-PSD; P=0.001). In the OCT-RNFL inferior quadrant, a sensitivity of 82% was recorded. Finally, the sensitivity of the FDT-PSD was 92%.ConclusionOur study shows that HF-PERG is a very sensitive test for detecting early damage of the RGC.

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“…In both structure and function, asymmetry has been a well known characteristic of POAG. Previous research has demonstrated intraeye asymmetry between superior and inferior measures of visual field sensitivity, 15 , 16 retinal nerve fiber layer (RNFL) thickness, 17 , 18 neuroretinal rim width, 19 , 20 and macular thickness 21 , 22 to be in association with POAG. In addition, the glaucoma hemifield test, which demonstrates the visual sensitivity asymmetry between corresponding superior and inferior visual field zones has been a sensitive indicator of visual field loss.…”

mentioning

confidence: 99%

Intraeye retinal nerve fiber layer and macular thickness asymmetry measurements for the discrimination of primary open-angle glaucoma and normal tension glaucoma

Khanal

Davey

Racette

et al. 2016

Journal of Optometry

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PurposeThe aim of this study was to evaluate the diagnostic capability of intraeye retinal nerve fiber layer (RNFL) thickness and macular thickness (MT) asymmetry measurements for the discrimination of normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT).MethodsA total of 90 subjects were enrolled including 30 consecutive healthy subjects, 30 consecutive subjects with POAG, and 30 consecutive subjects with NTG. RNFL thicknesses around the optic disc as well as MT measurements were taken with circular and radial SD-OCT scans. Intraeye retinal and MT asymmetry were calculated as the absolute difference between superior and inferior hemispheres of the eye using posterior pole asymmetry analysis protocol. Analysis of variance was used for comparison and areas under the receiver operating characteristic (AROC) were obtained for different parameters among the three diagnostic groups.ResultsThere was a significant difference in MT asymmetry for all comparison groups (normal-NTG, p < 0.05; normal-POAG, p < 0.001; and NTG-POAG, p < 0.001). Intraeye retinal nerve fiber thickness asymmetry measurements were not different between the groups (normal-NTG, p < 0.187; normal-POAG, p < 0.056; and NTG-POAG, p < 0.837). The area under ROC curves exceeded 0.800 for all the studied parameters, including the MT asymmetry except for intraeye RNFL thickness asymmetry which had the lowest AROC as well as the least sensitivity for identifying subjects with NTG from normal (AROC = 0.626, sensitivity = 30%); POAG from normal (AROC = 0.644, sensitivity = 37%) and NTG from POAG (AROC = 0.533, sensitivity = 13%).ConclusionThe intraeye MT asymmetry holds significant potential as a distinguishing parameter for NTG and POAG.

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Nerve fiber layer in glaucomatous hemifield loss: a case-control study with time- and spectral-domain optical coherence tomography

Cited by 5 publications

References 27 publications

Development of a new algorithm based on FDT Matrix perimetry and SD-OCT to improve early glaucoma detection in primary care

Development of a new algorithm based on FDT Matrix perimetry and SD-OCT to improve early glaucoma detection in primary care

Hemifield pattern electroretinogram in ocular hypertension: comparison with frequency doubling technology and optical coherence tomography to detect early optic neuropathy

Intraeye retinal nerve fiber layer and macular thickness asymmetry measurements for the discrimination of primary open-angle glaucoma and normal tension glaucoma

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