2010
DOI: 10.1590/s0004-27492010000500011
|View full text |Cite
|
Sign up to set email alerts
|

Use of CD25 as an immunohistochemical marker for acquired ocular toxoplasmosis

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
5
0

Year Published

2013
2013
2022
2022

Publication Types

Select...
5
1

Relationship

0
6

Authors

Journals

citations
Cited by 7 publications
(6 citation statements)
references
References 24 publications
1
5
0
Order By: Relevance
“…This finding indicated that IFN‐ γ and IL‐4 co‐expressing CD4 T cells were not naive T cells. Moreover, the CD25 and CD69 expression levels on the IFN‐ γ and IL‐4 cells reflected that this cell population was in an activated state, as reported by Miyamoto et al . More interesting is that the IFN‐ γ ‐ and IL‐4‐expressing cells expressed similar levels of these cell surface markers as Th1 and Th2 cells, though some differences existed between these cell populations as shown in Fig.…”
Section: Discussionsupporting
confidence: 74%
“…This finding indicated that IFN‐ γ and IL‐4 co‐expressing CD4 T cells were not naive T cells. Moreover, the CD25 and CD69 expression levels on the IFN‐ γ and IL‐4 cells reflected that this cell population was in an activated state, as reported by Miyamoto et al . More interesting is that the IFN‐ γ ‐ and IL‐4‐expressing cells expressed similar levels of these cell surface markers as Th1 and Th2 cells, though some differences existed between these cell populations as shown in Fig.…”
Section: Discussionsupporting
confidence: 74%
“…The regulatory activity on Th1, Th2, and CD8 + cells is mediated through the local secretion of TGF-ß ad IL-10 [ 44 ]. In the eye, infiltrates of CD4 + CD25 + T cells are specifically found in the retina of patients with recently acquired toxoplasmosis indicating that recently orally ingested parasite leads to the presence of these immune-regulatory cells in their infected retinas [ 26 ]. Their presence was explained as a mechanism to modulate the retinal damage, through a regulatory effect on the Th-1 response during the retinochoroiditis [ 14 ].…”
Section: Discussionmentioning
confidence: 99%
“…Data is qualitative [14] Measure biological function Assessment of signal transduction (e.g., arrays, such as ZeptoMARK), cell proliferation or differentiation induced as a result of ligand-receptor binding Provides indirect analysis of ligand-receptor interaction [2,15,16] Most such assays quantify complexes indirectly by measuring the levels of each molecular component independently or measuring the biological outcome of the complexes. Assays geared towards quantifying ligand-receptor complexes, such as FRET, are generally difficult to apply in a high-throughput platform like that required for analysis of a large numbers of samples or clinical diagnosis [1,[17][18][19][20][21][22][23]. The result is that the biologically and clinically significant parameters associated with ligand-receptor complexes, such as the fractional occupancy of a receptor by its ligand, remain understudied and underappreciated.…”
Section: Confocal Microscopymentioning
confidence: 99%
“…Most such assays quantify complexes indirectly by measuring the levels of each molecular component independently or measuring the biological outcome of the complexes. Assays geared towards quantifying ligand–receptor complexes, such as FRET, are generally difficult to apply in a high-throughput platform like that required for analysis of a large numbers of samples or clinical diagnosis [ 1 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. The result is that the biologically and clinically significant parameters associated with ligand–receptor complexes, such as the fractional occupancy of a receptor by its ligand, remain understudied and underappreciated.…”
Section: Introductionmentioning
confidence: 99%