Transplante autólogo do epitélio pigmentado da retina na degeneração macular relacionada com a idade

Siqueira, Rubens Camargo

doi:10.1590/s0004-27492009000100027

Cited by 7 publications

(6 citation statements)

References 36 publications

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“…Figure 2 shows the two subretinal injection techniques: (A) injection of cell suspensions and (B) injection of cells adhered to a matrix (scaffold) [20,88-90]. …”

Section: Routes Of Stem Cell Transplantation For Retinal Diseasesmentioning

confidence: 99%

Stem cell therapy for retinal diseases: update

Siqueira

2011

Stem Cell Res Ther

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Distinct stem cell types have been established from embryos and identified in the fetal tissues and umbilical cord blood as well as in specific niches in many adult mammalian tissues and organs such as bone marrow, brain, skin, eyes, heart, kidneys, lungs, gastrointestinal tract, pancreas, liver, breast, ovaries, and prostate. All stem cells are undifferentiated cells that exhibit unlimited self-renewal and can generate multiple cell lineages or more restricted progenitor populations that can contribute to tissue homeostasis by replenishing the cells or to tissue regeneration after injury. The remarkable progress of regenerative medicine in the last few years indicates promise for the use of stem cells in the treatment of ophthalmic disorders. Experimental and human studies with intravitreal bone marrow-derived stem cells have begun. This paper reviews recent advances and potential sources of stem cells for cell therapy in retinal diseases.

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“…Figure 2 shows the two subretinal injection techniques: (A) injection of cell suspensions and (B) injection of cells adhered to a matrix (scaffold) [20,88-90]. …”

Section: Routes Of Stem Cell Transplantation For Retinal Diseasesmentioning

confidence: 99%

Stem cell therapy for retinal diseases: update

Siqueira

2011

Stem Cell Res Ther

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“…More recently, our group conducted a prospective phase I trial to investigate the safety of intravitreal ABMC in patients with RP or cone-rod dystrophy, with promising results (53)(54)(55) . The history starts to be written in this very promising therapeutic field.…”

Section: C) Retinal Pigment Epithelium (Rpe) Repair With Bm Derived Smentioning

confidence: 99%

Possible mechanisms of retinal function recovery with the use of cell therapy with bone marrow-derived stem cells

Siqueira¹,

Voltarelli²,

Messias³

et al. 2010

Arq. Bras. Oftalmol.

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“…Cell culture experiments on RPE were carried out in 1980 [16]. Cultured human RPE cells were transplanted into the eyes of monkeys, first with open techniques and methods and later with closed cavity vitrectomy techniques [17–19]. The therapeutic potential of transplantation of the RPE was demonstrated at the Royal College of Surgeons in an animal model where a suspension of RPE cells labeled with carboxyfluorescein diacetate succinimidyl 5, 6-ester was injected in the subretinal space and the RPE cells were able to phagocytose the outer segments of photoreceptors [18].…”

Section: Cell-based Restoration Of Damage To the Retinal Pigment Ementioning

confidence: 99%

“…The trial concluded that outcomes with both approaches were comparable [30]. However, inability to transplant a uniform layer and formation of multilayered folds and contraction continue to be some of the challenges in RPE transplantation [17]. RPE cell suspensions also might not survive in an aged or defective host basal lamina after transplantation [31].…”

Section: Cell-based Restoration Of Damage To the Retinal Pigment Ementioning

confidence: 99%

Choice of Cell Source in Cell-Based Therapies for Retinal Damage due to Age-Related Macular Degeneration: A Review

John¹,

Natarajan

Parikumar³

et al. 2013

Journal of Ophthalmology

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Background. Age-related macular degeneration (AMD) is a complex disorder that affects primarily the macula involving the retinal pigment epithelium (RPE) but also to a certain extent the photoreceptor layer and the retinal neurons. Cell transplantation is a promising option for AMD and clinical trials are underway using different cell types. Methods. We hypothesize that instead of focusing on a particular cell source for concurrent regeneration of all the retinal layers and also to prevent exhaustive research on an array of cell sources for regeneration of each layer, the choice should depend on, precisely, which layer is damaged. Results. Thus, for a damage limited to the retinal pigment epithelial (RPE) layer, the choice we suggest would be RPE cells. When the damage extends to rods and cones, the choice would be bone marrow stem cells and when retinal neurons are involved, relatively immature stem cell populations with an inherent capacity to yield neuronal lineage such as hematopoietic stem cells, embryonic stem cells, or induced pluripotent stem cells can be tried. Conclusion. This short review will prove to be a valuable guideline for those working on cell therapy for AMD to plan their future directions of research and therapy for this condition.

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Transplante autólogo do epitélio pigmentado da retina na degeneração macular relacionada com a idade

Cited by 7 publications

References 36 publications

Stem cell therapy for retinal diseases: update

Stem cell therapy for retinal diseases: update

Possible mechanisms of retinal function recovery with the use of cell therapy with bone marrow-derived stem cells

Choice of Cell Source in Cell-Based Therapies for Retinal Damage due to Age-Related Macular Degeneration: A Review

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