2007
DOI: 10.1590/s0004-27492007000300030
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Abstract: A neovascularização ocorre em situações patológicas como uma tentativa de reparação de danos teciduais através da formação local de neovasos. No entanto, em retinopatias proliferativas, como a retinopatia diabética e a degeneração macular relacionada à idade (DMRI), geralmente a neovascularização traz consigo efeitos visuais devastadores.O processo de formação de vasos sangüíneos é conhecido como angiogênese. Esse fenômeno ocorre em condições fisiológicas e patológicas. A angiogênese fisiológica ocorre durante… Show more

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Cited by 16 publications
(12 citation statements)
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References 61 publications
(80 reference statements)
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“…Angiogenesis is mediated by a huge number of stimulatory and inhibitory factors. An imbalance between these molecules occurs in pathological conditions [Damico, 2006]. Vascular endothelial growth factor (VEGF) is a crucial pro‐angiogenic factor and the main promotor of endothelial cell (EC) growth, migration, and vessel dilation and permeability.…”
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confidence: 99%
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“…Angiogenesis is mediated by a huge number of stimulatory and inhibitory factors. An imbalance between these molecules occurs in pathological conditions [Damico, 2006]. Vascular endothelial growth factor (VEGF) is a crucial pro‐angiogenic factor and the main promotor of endothelial cell (EC) growth, migration, and vessel dilation and permeability.…”
mentioning
confidence: 99%
“…AMD is the leading cause of blindness in individuals over 50 years in developed countries, increasing with age [Wang et al, 2004], and affecting approximately 50 million people worldwide [Ferguson and Apte, 2008]. AMD‐related visual loss is a complex process starting by the deposition of debris in the outer retina [Damico, 2006; Andreoli and Miller, 2007]. The deposition of insoluble material, the calcification and increase in thickness of Bruch's membrane, and a less fenestrated and thinner choriocapillaris lead to photoreceptors/retinal pigment epithelium hypoxia resulting in a stimulus for VEGF release [Shibuya, 2001; Adamis, 2005; deJong, 2006; Semenza, 2007].…”
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confidence: 99%
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“…It is essential for various physiological processes, such as the growth and development of organs, capillary growth, the reproductive cycle and the healing of wounds. On the other hand, it may also contribute to the development of various pathological processes, such as rheumatoid arthritis, diabetic retinopathy, and the growth and metastasis of tumors 1, 2.…”
Section: Introductionmentioning
confidence: 99%