Sarcoma granulocítico em órbita: relato de caso

Fonseca, Nilson Lopes da; Pavês, Luis; Nakanami, Deise Mitsuko; Seixas, Maria Teresa; Manso, Paulo Góis

doi:10.1590/s0004-27492005000400026

Cited by 8 publications

(6 citation statements)

References 16 publications

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“…Most cases, in patients without a previous diagnosis, progress to AML within a few months. However, some patients do not develop leukemic hematologic evidence of the disease for as long as 30 months following the presence of an orbital tumor 21. In our case, the orbital mass preceded any hematologic manifestations at the time of presentation.…”

Section: Discussionmentioning

confidence: 52%

<p>Unilateral Proptosis As An Initial Sign Of Acute Myeloid Leukemia In A Child: A Case Report</p>

Almalki¹,

Alotaibi²,

Jabr³

et al. 2019

IMCRJ

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Granulocytic sarcoma (chloroma) is a rare malignant solid tumor representing an extramedullary manifestation of acute myeloid leukemia (AML). Rarely, a chloroma can develop as the sole manifestation and its appearance may precede the systemic manifestations of acute myelocytic leukemia by months to years. We report a rare case of unilateral orbital mass presenting with progressive proptosis involving left globe in an otherwise healthy child, and give a brief overview of the literature about this unusual presentation. Leukemic infiltration should be considered in the differential diagnosis of orbital masses and proptosis even in the absence of systemic manifestations of AML. Early detection and management are crucial to preserve vision and prevent complications.

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Section: Discussionmentioning

confidence: 52%

<p>Unilateral Proptosis As An Initial Sign Of Acute Myeloid Leukemia In A Child: A Case Report</p>

Almalki¹,

Alotaibi²,

Jabr³

et al. 2019

IMCRJ

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“…10 In most cases, MS progresses to AML in few months but in a few, they did not develop hematologic malignancy for as long as 30 months. 11 In the absence of systemic leukemic manifestations, the diagnosis of orbital MS can be challenging, and the other differentials are malignant lymphoma, rhabdomyosarcoma, neuroblastoma, retinoblastoma, small round cell tumors, Ewings sarcoma and metastasis. 12 MS is the second commonest orbital tumor after Burkitt's lymphoma that causes proptosis.…”

Section: Case Reportmentioning

confidence: 99%

Isolated unilateral orbital myeloid sarcoma: a case report

Sonalika

Latha

Jayaraman

et al. 2022

Int J Contemp Pediatr

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Myeloid sarcoma (MS) is a rare solid tumor consisting of immature myeloid cells occurring at an extramedullary site. It can present before, with, or after the manifestation of acute myeloid leukemia or other myeloproliferative diseases, and a few patients never develop bone marrow infiltration. Only a few isolated cases of pediatric orbital MS have been reported, and they are often misdiagnosed. We report a rare case of pediatric isolated orbital MS in a 5-year-old boy who presented with unilateral proptosis. The patient was diagnosed with MS based on MRI and Immunohistochemistry results. Subsequently the patient underwent chemotherapy supported with radiotherapy and showed significant response. Isolated orbital MS presents with clinical and radiological features which are often misleading, making the diagnosis difficult. Therefore, MS should be considered in the differential diagnosis of orbital masses and proptosis even in the absence of acute myeloid leukemia (AML).

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“…Menos frequentes são a orbita, seios paranasais e sistema nervoso central 3 . Pode anteceder, acompanhar ou indicar recorrência de uma LMA já tratada 4 , e é mais frequente em crianças do que em adultos 5 . Seu surgimento na fase de remissão das leucemias é fator de mau prognóstico, embora tenham sito relatados casos de boa evolução com diagnóstico precoce e tratamento adequado 21 .…”

Section: Introductionunclassified