Celiac crisis in an adult type 1 diabetes mellitus patient: a rare manifestation of celiac disease

Toyoshima, Marcos Tadashi Kakitani; Queiroz, Márcia Silva; Silva, Maria Elizabeth Rossi; Corrêa-Giannella, Maria Lúcia; Nery, Márcia

doi:10.1590/s0004-27302013000800011

Cited by 5 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two cases with IgA deficiency were recorded, requiring HLA-DQ2/DQ8 screening for diagnostic confirmation. 4 , 8 The most common histopathological presentation was Marsh 3, with a predominance of subtype c. 4 , 6 , 9 , 10 A total of 27 cases showed improved clinical status after the introduction of a gluten-free diet, 4 , 6 , 9 - 22 nine patients required corticosteroids for symptom remission, 4 , 6 , 12 , 18 and one death was recorded due to refeeding syndrome. 7 …”

Section: Discussionmentioning

confidence: 99%

Celiac Crisis: an unusual presentation of gluten-sensitive enteropathy

et al. 2018

View full text Add to dashboard Cite

Celiac disease (CD)—also known as gluten-sensitive enteropathy—is a chronic, genetically predisposing and autoimmune entity with a wide range of clinical manifestations triggered by gluten ingestion, which affects 1% of the general population. Currently, up to 60% of the diagnosis of CD is in adults due to the atypical course of the disease. The severe acute onset of CD—also called celiac crisis—is very uncommon and is still not well documented in adults. We report the case of a 58-year-old man who presented a 45-day history of subtle-onset diarrhea followed by malabsorption syndrome with progressive weight loss, anasarca, and electrolyte disturbances. The diagnostic work-up included an upper digestive endoscopy, which showed scalloping of the duodenal mucosa with pathological features confirmed on biopsies. Specific antibodies were positive, and a satisfactory clinical response was obtained once a gluten-free diet was started. Celiac crisis is a rare initial presentation of CD characterized by severe diarrhea, dehydration, weight loss, hypoproteinemia, and metabolic and electrolyte disturbances. Although rare, it should be considered in patients with apparently unexplained chronic diarrhea.

show abstract