Association of insulin resistance and GLP-2 secretion in obesity: a pilot study

Geloneze, Bruno; Lima, Marcelo Miranda de Oliveira; Pareja, José Carlos; Barreto, Maria Rita Lazzarini; Magro, Daniéla Oliveira

doi:10.1590/s0004-27302013000800008

Cited by 19 publications

(10 citation statements)

References 18 publications

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“…However, both compounds improved metabolic parameters (energy intake, weight gain, fat mass, and glucose homeostasis) [112], highlighting that GLP-1 and 2 not only decrease gut permeability but also improve glucose homeostasis. Similar findings were also made in humans, in which the GLP-2 concentration of diabetic subjects inversely correlated with insulin resistance [113]. Another prebiotic treatment with inulin pasta improved the intestinal permeability, measured as zonulin expression, and GLP-2 levels in healthy young subjects [114].…”

Section: The Gut Microbiota Alters Satiety Signalingsupporting

confidence: 73%

Causality of small and large intestinal microbiota in weight regulation and insulin resistance

Scheithauer

Dallinga‐Thie

Vos

et al. 2016

Molecular Metabolism

148

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ObjectiveThe twin pandemics of obesity and Type 2 diabetes (T2D) are a global challenge for health care systems. Changes in the environment, behavior, diet, and lifestyle during the last decades are considered the major causes. A Western diet, which is rich in saturated fat and simple sugars, may lead to changes in gut microbial composition and physiology, which have recently been linked to the development of metabolic diseases.MethodsWe will discuss evidence that demonstrates the influence of the small and large intestinal microbiota on weight regulation and the development of insulin resistance, based on literature search.ResultsAltered large intestinal microbial composition may promote obesity by increasing energy harvest through specialized gut microbes. In both large and small intestine, microbial alterations may increase gut permeability that facilitates the translocation of whole bacteria or endotoxic bacterial components into metabolic active tissues. Moreover, changed microbial communities may affect the production of satiety-inducing signals. Finally, bacterial metabolic products, such as short chain fatty acids (SCFAs) and their relative ratios, may be causal in disturbed immune and metabolic signaling, notably in the small intestine where the surface is large. The function of these organs (adipose tissue, brain, liver, muscle, pancreas) may be disturbed by the induction of low-grade inflammation, contributing to insulin resistance.ConclusionsInterventions aimed to restoring gut microbial homeostasis, such as ingestion of specific fibers or therapeutic microbes, are promising strategies to reduce insulin resistance and the related metabolic abnormalities in obesity, metabolic syndrome, and type 2 diabetes. This article is part of a special issue on microbiota.

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Section: The Gut Microbiota Alters Satiety Signalingsupporting

confidence: 73%

Causality of small and large intestinal microbiota in weight regulation and insulin resistance

Scheithauer

Dallinga‐Thie

Vos

et al. 2016

Molecular Metabolism

148

View full text Add to dashboard Cite

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“…However, the GLP‐2 concentrations in the ID cohort were lower than post‐prandial concentrations (>4 ng/mL) reported in patients with type‐2 diabetes mellitus (T2DM) , which may reflect the different underlying pathological processes of these two conditions. Given that an inverse relationship between GLP‐2 secretion and insulin sensitivity has been reported , further studies on the relationship between GLP‐2 secretion and equine ID are justified.…”

Section: Discussionmentioning

confidence: 99%

Glucagon‐like peptide‐2: A potential role in equine insulin dysregulation

Laat

Fitzgerald

Sillence

et al. 2018

Equine Veterinary Journal

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“…C-terminal telopeptide (CTX) was measured using an ELISA kit (Immuno Diagnostic Systems Ltd, United Kingdom) [ 25 ]; the normal reference range for postmenopausal women is 0.142–1.351 ng/mL, with an intra-assay variation of 1.7–3% and inter-assay variation of 3–11%. GLP-2 was measured using an ELISA kit (Millipore Corporation, United States) [ 26 , 27 ] with a standard curve of 1–64 ng/mL, intra-assay variation of less than 10%, and inter-assay variation of less than 12%. This assay measures total levels of GLP-2, including active [ 1 - 33 ] and inactive [ 3 - 33 ] isoforms.…”

Section: Methodsmentioning

confidence: 99%

The role of enteric hormone GLP-2 in the response of bone markers to a mixed meal in postmenopausal women with type 2 diabetes mellitus

Lopes

Schwartz

Ferraz-de-Souza

et al. 2015

Diabetol Metab Syndr

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BackgroundType 2 diabetes mellitus (T2D) is a complex disease associated with several chronic complications, including bone fragility and high fracture risk due to mechanisms not yet fully understood. The influence of the gastrointestinal tract and its hormones on bone remodeling has been demonstrated in healthy individuals. Glucagon-like peptide 2 (GLP-2), an enteric hormone secreted in response to nutrient intake, has been implicated as a mediator of nutrient effects on bone remodeling. This study aimed to analyze the dynamics of bone resorption marker C-terminal telopeptide of type I collagen (CTX), bone formation marker osteocalcin, and GLP-2 in response to a mixed meal in diabetic postmenopausal women.MethodsForty-three postmenopausal women with osteopenia or osteoporosis (20 controls – group CO – and 23 diabetic – group T2D) were subjected to a standard mixed meal tolerance test, with determination of serum CTX, plasma osteocalcin and serum GLP-2 concentrations at baseline and 30, 60, 120 and 180 minutes after the meal.ResultsT2D women had higher body mass index as well as higher femoral neck and total hip bone mineral density. At baseline, luteinizing hormone, follicle-stimulating hormone, osteocalcin and CTX levels were lower in group T2D. In response to the mixed meal, CTX and osteocalcin levels decreased and GLP-2 levels increased in both groups. The expected CTX suppression in response to the mixed meal was lower in group T2D.ConclusionsBone turnover markers were significantly reduced in T2D women at baseline. Confirming the role of nutrient intake as a stimulating factor, GLP-2 increased in response to the mixed meal in both groups. Importantly, CTX variation in response to the mixed meal was reduced in T2D women, suggesting abnormal response of bone remodeling to nutrient intake in T2D.

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Association of insulin resistance and GLP-2 secretion in obesity: a pilot study

Cited by 19 publications

References 18 publications

Causality of small and large intestinal microbiota in weight regulation and insulin resistance

Causality of small and large intestinal microbiota in weight regulation and insulin resistance

Glucagon‐like peptide‐2: A potential role in equine insulin dysregulation

The role of enteric hormone GLP-2 in the response of bone markers to a mixed meal in postmenopausal women with type 2 diabetes mellitus

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