Hipotireoidismo congênito: recomendações do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e Metabologia

Maciel, Léa Maria Zanini; Kimura, Edna Teruko; Nogueira, Célia Regina; Mazeto, Gláucia Maria Ferreira da Silva; Magalhães, Patrícia Künzle Ribeiro; Nascimento, Marilza Leal; Nesi-França, Suzana; Vieira, Sandra Elisabete

doi:10.1590/s0004-27302013000300004

Cited by 30 publications

(27 citation statements)

References 47 publications

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“…Currently, CH has a worldwide incidence of 1 in approximately 3,500 live births 4 . A similar incidence has been observed in Brazil, where the estimated rates range from 1:2,595 to 1:4,795 live births 1,18 . In the PNTN, CH is screened by dosing thyroid-stimulating hormone (TSH) with filter paper.…”

Section: Discussionsupporting

confidence: 76%

Assessment of newborn screening in the public health system of a municipality in northern Rio Grande do Sul

et al. 2018

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Introduction: Newborn screening allows the screening of diseases that are still in the asymptomatic period and whose early diagnosis and treatment are associated with reduced infant morbidity and mortality. The aim of this study was to evaluate the public National Newborn Screening Program in the municipality of Carazinho, state of Rio Grande do Sul (RS), Brazil. Methods: This was a population-based, retrospective, descriptive study. We collected and transcribed data from a database of the Carazinho municipal laboratory, which is affiliated with the referral center for newborn screening in RS. The records of all individuals undergoing newborn screening from 2005 to 2010 were reviewed, and information was collected on the program coverage, time elapsed between birth and screening (first collection), and test results. Results: The program had a coverage of 75.5%. One suspected case of phenylketonuria, three suspected cases of congenital hypothyroidism and no suspected cases of hemoglobinopathy were identified. In addition, there were 18 positive results for hemoglobin S heterozygosity, five for hemoglobin D heterozygosity, two for hemoglobin C heterozygosity, and one for a rare variant hemoglobin. When analyzing the newborn's age at the time of blood collection, it was observed that 63.1% were within the recommended age range. Conclusions: Our findings suggest the need for optimization of public newborn screening in the evaluated municipality. The strategies to be adopted should include education of the population and especially of managers and health professionals about the importance of newborn screening.

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Section: Discussionsupporting

confidence: 76%

Assessment of newborn screening in the public health system of a municipality in northern Rio Grande do Sul

et al. 2018

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“…The cutoff of confirmatory serum TSH of 10 µU/mL would imply a loss of 70 cases of permanent conditions (23 CH and 47 hyperthyrotropinemia). We also found that 15.2% of the children with serum TSH levels between 4.2 and 6 µU/mL would not have been diagnosed if the TSH cutoff point was 6 µU/mL, according to the national recommendation (22).…”

Section: Discussionmentioning

confidence: 73%

Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil

Matos

Ramalho

Carvalho

et al. 2016

Arch. Endocrinol. Metab.

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Objectives: To assess the evolution to permanent or transient conditions in children with positive neonatal TSH tests in Sergipe, Brazil, from 2004 to 2010. Subjects and methods: Out of 193,794 screened newborns, 713 presented a neonatal TSH level higher than the local cutoff (5.2 µU/mL). From the confirmatory serum TSH values, the children were diagnosed with initial congenital hypothyroidism (CH) or suspect CH. From the evolution, they were classified as permanent CH, hyperthyrotropinemia, or transient TSH elevation. The mean incidence of each final condition was calculated for the total period of time. Results: The initial diagnosis included 37 CH (18.1%) and 167 suspect CH (81.9%) cases. The final diagnosis included 46 cases of permanent CH (22.5%), 56 of hyperthyrotropinemia (27.5%), and 102 of transient TSH elevation (50.0%). Out of the 37 cases of initial CH, 23 (62.2%) had permanent CH, nine (24.3%) had hyperthyrotropinemia, and five (13.5%) had transient TSH elevation. Out of the 167 suspect CH cases, 23 (13.8%) had permanent CH, 47 (28.1%) had hyperthyrotropinemia and 97 (58.1%) had transient TSH elevation. The mean incidence after the follow up was 1:4,166 for permanent CH, 1:3,448 for hyperthyrotropinemia, and 1:1,887 for transient TSH elevation. Eighty-six percent of the children with an initial diagnosis of CH and 41.9% with suspect CH had a permanent condition (CH or hyperthyrotropinemia). Conclusions: The follow-up of children with an initial diagnosis of CH or suspect CH is necessary to determine whether the disorder is permanent because predicting the evolution of the condition is difficult. Arch Endocrinol Metab. 2016;60(5):

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“…Early diagnosis and treatment of children with CH bring enormous benefits to the family and community, as they avoid social, emotional and financial costs through prevention of intellectual disability (4) . However, although early screening programs for CH have proven effective in reducing intellectual disability, the key issue is identifying neurocognitive sequelae, even the subtlest ones, which may persist despite early treatment (2,(4)(5)(6)9,11,19) . Studies have reported that individuals with CH may present attention, memory, visuocognitive, visuospatial and psychomotor disorders (1,10,12,14,(18)(19)(20)24) .…”

Section: Discussionmentioning

confidence: 99%

“…Congenital hypothyroidism (CH) is a pediatric endocrine disorder characterized by insufficient thyroid hormone production caused by thyroid dysgenesis or dysormonogenesis (1)(2)(3) . Its incidence is of approximately 1 in 3000-4000 newborns, with a two to three-fold higher prevalence in females (4)(5)(6) . It is the leading cause of preventable intellectual disability when diagnosed and treated early (4,(7)(8)(9)(10)(11) .…”

Section: Introductionmentioning

confidence: 99%

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Desempenho em habilidades motoras, comunicativas e cognitivas de crianças com hipotireoidismo congênito tratadas desde o período neonatal

Lamônica

Anastácio-Pessan

Ferraz³

et al. 2020

CoDAS

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RESUMO Objetivo Comparar o desempenho das habilidades motora grossa, motora fina-adaptativa, linguagem, cognitiva e pessoal-social de meninas entre 36 e 70 meses com hipotireoidismo congênito tratado no período pós-natal com seus pares sem alterações tireoidianas. Método Participaram 15 meninas com diagnóstico de hipotireoidismo congênito, com idade cronológica variando de 36 a 70 meses no Grupo Experimental (GE); e 15 meninas sem alterações tireoidianas no Grupo Comparativo (GC), pareadas por idade cronológica e nível socioeconômico. Os instrumentos de avaliação utilizados foram: Entrevista com os pais; Teste de Vocabulário por Imagem Peabody (TVIP-R); e Teste de Triagem do Desenvolvimento de Denver II (TTDD-II). Foi realizada a avaliação psicológica, quanto ao nível intelectual, com a aplicação da Stanford-Binet Intelligence Scale (SBIS). A estatística foi realizada por meio de análise descritiva, teste “t” de Student e Teste de Mann-Whitney, nível de significância de p <5%. Resultados Na comparação do TVIP-R e SBIS, houve diferença estatisticamente significante entre o GE e o GC. Na comparação entre as áreas do TTDD-II, houve diferença estatisticamente significante entre os grupos para as áreas de Linguagem, Motora Grossa e Motora Fina-Adaptativa. Conclusão O presente estudo confirmou a interferência do Hipotireoidismo Congênito no desenvolvimento infantil, mesmo quando diagnosticado e tratado precocemente, levando a mudanças no desenvolvimento que podem trazer prejuízos nas áreas motora, cognitiva e linguística.

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Hipotireoidismo congênito: recomendações do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e Metabologia

Cited by 30 publications

References 47 publications

Assessment of newborn screening in the public health system of a municipality in northern Rio Grande do Sul

Assessment of newborn screening in the public health system of a municipality in northern Rio Grande do Sul

Evolution to permanent or transient conditions in children with positive neonatal TSH screening tests in Sergipe, Brazil

Desempenho em habilidades motoras, comunicativas e cognitivas de crianças com hipotireoidismo congênito tratadas desde o período neonatal

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