Hipoglicemia hiperinsulinêmica da infância: Análise de dados clínicos de uma amostra brasileira

Hyperinsulinaemic hypoglycaemia (HH) is a biochemical finding of low blood glucose levels due to the dysregulation of insulin secretion from pancreatic β-cells. Under normal physiological conditions, glucose metabolism is coupled to β-cell insulin secretion so that blood glucose levels are maintained within the physiological range of 3.5–5.5 mmol/L. However, in HH this coupling of glucose metabolism to insulin secretion is perturbed so that insulin secretion becomes unregulated. HH typically occurs in the neonatal, infancy and childhood periods and can be due to many different causes. Adults can also present with HH but the causes in adults tend to be different. Somatostatin (SST) is a peptide hormone that is released by the delta cells (δ-cells) in the pancreas. It binds to G protein-coupled SST receptors to regulate a variety of location-specific and selective functions such as hormone inhibition, neurotransmission and cell proliferation. SST plays a potent role in the regulation of both insulin and glucagon secretion in response to changes in glucose levels by negative feedback mechanism. The half-life of SST is only 1–3 min due to quick degradation by peptidases in plasma and tissues. Thus, a direct continuous intravenous or subcutaneous infusion is required to achieve the therapeutic effect. These limitations prompted the discovery of SST analogues such as octreotide and lanreotide, which have longer half-lives and therefore can be administered as injections. SST analogues are used to treat different forms of HH in children and adults and therapeutic effect is achieved by suppressing insulin secretion from pancreatic β-cells by complex mechanisms. These treatments are associated with several side effects, especially in the newborn period, with necrotizing enterocolitis being the most serious side effect and hence SS analogues should be used with extreme caution in this age group.

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“… 73 Many studies document the use of SST analogues for treating childhood HH, dating back to 1977. 14 , 27 , 67 …”

Section: The Role Of Sst Analogues In Treatment Of Hhmentioning

confidence: 99%

Somatostatin analogues for the treatment of hyperinsulinaemic hypoglycaemia

Haris

Saraswathi

Hussain

2020

Therapeutic Advances in Endocrinology

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Assessment of Nifedipine therapy in Hyperinsulinemic Hypoglycemia due to mutations in the ABCC8 gene.

Güemes

Shah

Silvera

et al. 2016

The Journal of Clinical Endocrinology & Metabolism

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Topics of pre-hospital care for schoolchildren: the perspective of professionals of the Mobile Emergency Care Service (SAMU)

Mota¹,

Andrade

2015

Texto contexto - enferm.

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This study aimed to investigate from the perspective of professional SAMU, the main themes of pre-hospital care (PHC), as subsidies for development of an educational tool focused on the school population. A qualitative study, four meetings in the focus group format, with 19 professional SAMU, in a municipality of Santa Catarina, Brazil. Data were categorized and analyzed with thematic analysis. The results highlighted the main issues or health problems of urgent and emergency tool for modeling and possible application in the context of the School Health Program. It was concluded that the selected topics are critical in the context of the APH, the potential severity and the possibility they involve children, even within the school environment.

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Hipoglicemia hiperinsulinêmica da infância: Análise de dados clínicos de uma amostra brasileira

Cited by 3 publications

References 16 publications

Somatostatin analogues for the treatment of hyperinsulinaemic hypoglycaemia

Somatostatin analogues for the treatment of hyperinsulinaemic hypoglycaemia

Assessment of Nifedipine therapy in Hyperinsulinemic Hypoglycemia due to mutations in the ABCC8 gene.

Topics of pre-hospital care for schoolchildren: the perspective of professionals of the Mobile Emergency Care Service (SAMU)

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