The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus

Brondani, Letícia de Almeida; Assmann, Taís Silveira; Duarte, Guilherme Coutinho Kullmann; Gross, Jorge Luiz; Canani, Luís Henrique Santos; Crispim, Daisy

doi:10.1590/s0004-27302012000400001

Cited by 96 publications

(106 citation statements)

References 57 publications

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“…Brondani et al characterized energy expenditure in humans as resting metabolic rate, physical activity and adaptive thermogenesis [8]. BAT mitochondria are the main site for adaptive thermogenesis, which responds to diet and changes in temperature.…”

Section: Introductionmentioning

confidence: 99%

Early Overfeed-Induced Obesity Leads to Brown Adipose Tissue Hypoactivity in Rats

Almeida

Fabricio

Trombini

et al. 2013

Cell Physiol Biochem

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Background/Aims: Brown adipose tissue activation has been considered a potential anti-obesity mechanism because it is able to expend energy through thermogenesis. In contrast, white adipose tissue stores energy, contributing to obesity. We investigated whether the early programming of obesity by overfeeding during lactation changes structure of interscapular brown adipose tissue in adulthood and its effects on thermogenesis. Methods: Birth of litters was considered day 0. On day 2, litter size was adjusted to normal (9 pups) and small (3 pups) litters. On day 21, the litters were weaned. A temperature transponder was implanted underneath interscapular brown adipose tissue pads of 81-day-old animals; local temperature was measured during light and dark periods between days 87 and 90. The animals were euthanized, and tissue and blood samples were collected for further analysis. The vagus and retroperitoneal sympathetic nerve activity was recorded. Results: Small litter rats presented significant lower interscapular brown adipose tissue temperature during the light (NL 37.6°C vs. SL 37.2°C) and dark (NL 38°C vs. SL 37.6°C) periods compared to controls. Morphology of small litter brown adipose tissue showed fewer lipid droplets in the tissue center and more and larger in the periphery. The activity of vagus nerve was 19,9% greater in the small litter than in control (p<0.01), and no difference was observed in the sympathetic nerve activity. In adulthood, the small litter rats were 11,7% heavier than the controls and presented higher glycemia 13,1%, insulinemia 70% and corticosteronemia 92,6%. Conclusion: Early overfeeding programming of obesity changes the interscapular brown adipose tissue structure in adulthood, leading to local thermogenesis hypoactivity, which may contribute to obesity in adults.

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Section: Introductionmentioning

confidence: 99%

Early Overfeed-Induced Obesity Leads to Brown Adipose Tissue Hypoactivity in Rats

Almeida

Fabricio

Trombini

et al. 2013

Cell Physiol Biochem

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“…UCP1, which is a mitochondrial carrier protein, plays an important role in metabolic regulation and energy balance [36,37]. To determine the effect of Kampo medicines on the expression of mitochondria metabolic-related genes in the infected cells, we examined the expression of the UCP1 gene by RT-PCR.…”

Section: Resultsmentioning

confidence: 99%

Hochuekkito, a Japanese Herbal Medicine, Restores Metabolic Homeostasis between Mitochondrial and Glycolytic Pathways Impaired by Influenza A Virus Infection

Takanashi

Dan²,

Kanzaki³

et al. 2017

Pharmacology

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Background: Hochuekkito (HKT), a traditional Japanese herbal medicine (Kampo), has been used to treat symptoms of several diseases. In a recent clinical study, HKT was shown to be protective against the influenza virus infection. However, the underlying mechanism of the prophylactic effect is not clear. Mitochondrial and glycolytic pathways play important roles in cellular energy metabolism to maintain biological functions. These metabolic pathways are affected by the influenza virus infection. In this study, we examined the relationship between the preventive effects of HKT against the influenza virus infection and cellular energy metabolism in mitochondria and glycolysis using Madin-Darby canine kidney cells and influenza A/PR/8/34 (H1N1) virus (IAV). Methods: Mitochondrial and glycolytic metabolic pathways were evaluated on the basis of the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR), respectively, using the XF24 Extracellular Analyzer. Results: The OCR/ECAR ratio in IAV-infected cells was lower than that in control cells. Cells that were treated with HKT before IAV infection showed a metabolic pattern similar to that in the control cells (increase in both OCR and ECAR). Conclusions: Our results suggest that HKT not only activates both mitochondrial and glycolytic energy metabolism in IAV-infected cells but also helps maintain metabolic homeostasis similar to that in noninfected cells.

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“…The heat released by the process of thermogenesis through BAT is necessary for the hibernators for enduring the cold environments. The UCPs helps in the transmission of anions from the inner mitochondrial membrane to the outer and vice versa [11,18]. UCP1, when triggered, it bypasses the electrochemical gradient that drives ATP synthesis and therefore stimulates respiratory chain activity.…”

Section: Discussionmentioning

confidence: 99%

“…UCP1, when triggered, it bypasses the electrochemical gradient that drives ATP synthesis and therefore stimulates respiratory chain activity. Heat, which is being produced as the by-product, is from the combustion of accessible substrates and distributed all over the body by circulation [11,18,19].…”

Section: Discussionmentioning

confidence: 99%

Induction of Brown Adipose Tissue: A Review

Sagayaraj

Akilashree

2018

Asian J Pharm Clin Res

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Objective: Obesity is the major problem which may lead to many other health ailments such as atherosclerosis, stroke, and depression. Both the cause as well as the treatment lies in the adipose tissue. The two main adipocytes, white adipose tissue (WAT) and brown adipose tissue (BAT) are responsible for the accumulation of fat and transformation of fat into heat, respectively. This review discusses the induction of BAT and browning of WAT by different pathways and activators to decrease the rate of obesity.Methods: Understanding the regulators, activators and secreted proteins which induce browning of WAT to BAT, as the BAT engage in thermogenesis process and transform fat into heat rather than storing it (WAT). Some of the core regulators are peroxisome proliferator-activated receptor-γ, PRDM16, PGC-1α. Results:A basic study explained about the origin of BAT and its functions, the function of hormones in BAT growth and its regulations. These studies provided the platform to understand about the mechanism of regulators, activators and secreted proteins which help in treating obesity and its related disorders by inducing the amount of BAT. Conclusion:The major health ailments caused by obesity can be reduced by increasing the activity of BAT and transforming WAT into BAT. A challenging way to treat these ailments is by regulating the activators and hormones responsible for the induction of BAT, so it transforms the excess fat into heat and avoiding the accumulation of fat. By understanding the role of regulators in the adipose tissue can provide various methods to reduce the chance of obesity and enhance efficient treatment in both children and adults.

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The role of the uncoupling protein 1 (UCP1) on the development of obesity and type 2 diabetes mellitus

Cited by 96 publications

References 57 publications

Early Overfeed-Induced Obesity Leads to Brown Adipose Tissue Hypoactivity in Rats

Early Overfeed-Induced Obesity Leads to Brown Adipose Tissue Hypoactivity in Rats

Hochuekkito, a Japanese Herbal Medicine, Restores Metabolic Homeostasis between Mitochondrial and Glycolytic Pathways Impaired by Influenza A Virus Infection

Induction of Brown Adipose Tissue: A Review

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