2012
DOI: 10.1590/s0004-27302012000100010
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Abstract: SUMMARYResistance to thyroid hormone (RTH) is a rare autosomal dominant inherited disorder characterized by end-organ reduced sensitivity to thyroid hormone. This syndrome is caused by mutations of the thyroid hormone receptor (TR) β gene, and its clinical presentation is quite variable. Goiter is reported to be the most common finding. A close association of TRβ mutations with human cancers has become apparent, but the role of TRβ mutants in the carcinogenesis is still undefined. Moreover, higher TSH levels, … Show more

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Cited by 8 publications
(5 citation statements)
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“…These findings suggest that cross talks of the activated KRAS pathway with the activated PI3K-AKT and β-catenin signaling mediated by TRβPV induced dedifferentiated thyroid cancer. THRB gene mutations are rare, but case studies have reported patients with thyroid cancer [29] , [30] , [31] , [32] , [33] , [34] . Thousands of rare mutations have been identified in the human genome.…”
Section: Discussionmentioning
confidence: 99%
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“…These findings suggest that cross talks of the activated KRAS pathway with the activated PI3K-AKT and β-catenin signaling mediated by TRβPV induced dedifferentiated thyroid cancer. THRB gene mutations are rare, but case studies have reported patients with thyroid cancer [29] , [30] , [31] , [32] , [33] , [34] . Thousands of rare mutations have been identified in the human genome.…”
Section: Discussionmentioning
confidence: 99%
“…However, our data could explain the in vivo findings that the Pax8 mRNA level was less than that in WT mice, Kras G12D mice, and Thrb PV/PV mice ( Figure 5 D ). While mutations of the THRβ gene are rare in human thyroid cancer [29] , [30] , [31] , [32] , [33] , [34] , [40] , the collaboration of MYC with TRβ mutants to suppress the expression of the Pax8 gene has yet to be uncovered. However, our findings exemplified how MYC could collaborate with other transcription factors and oncogenes to suppress the expression of the Pax8 gene and thereby could participate in the induction of the dedifferentiation process.…”
Section: Discussionmentioning
confidence: 99%
“…Three recent reports have documented three cases of RTH associated with PTC (5) (6) (7). The first case is a 38-year-old Korean woman with generalized RTH and incidental PTC (5).…”
Section: Discussionmentioning
confidence: 99%
“…She had no signs of hypothyroidism under treatment with 250 μg/day of l -T 4 (5.1 μg/kg per day). The second case is a 29-year-old Brazilian man with a family history of RTH (6). He was diagnosed with RTH at the age of 15 years and his medical history included atrial fibrillation.…”
Section: Discussionmentioning
confidence: 99%
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