volume 56, issue 1, P67-71 2012
DOI: 10.1590/s0004-27302012000100010
View full text
Has erratum
|
Sign up to set email alerts
|
Share

Abstract: SUMMARYResistance to thyroid hormone (RTH) is a rare autosomal dominant inherited disorder characterized by end-organ reduced sensitivity to thyroid hormone. This syndrome is caused by mutations of the thyroid hormone receptor (TR) β gene, and its clinical presentation is quite variable. Goiter is reported to be the most common finding. A close association of TRβ mutations with human cancers has become apparent, but the role of TRβ mutants in the carcinogenesis is still undefined. Moreover, higher TSH levels,…

Expand abstract
Editorial notices