Spirulina, exercício e controle da glicemia em ratos diabéticos

Abstract

RESUMOObjetivo: O objetivo do presente estudo foi analisar o efeito da Spirulina e/ou do treinamento físico na homeostase glicêmica de ratos diabéticos. Materiais e métodos: Ratos Wistar diabé-ticos aloxânicos foram separados em quatro grupos: diabético controle (DC); diabético Spirulina (DS); diabético exercício (DE); diabético Spirulina exercício (DSE). Resultados: Não foram observadas diferenças significativas entre os grupos para: peso corporal, ingestão alimentar, tolerância à glicose, tolerância à insulina, concentrações de lactato sanguíneo durante teste de esforço. Para as concentrações de insulina, o grupo DS apresentou valor significativamente menor quando comparado ao grupo DC (pâncreas) e DE e DES (soro). Conclusão: Os protocolos de exercício e de suplementação com Spirulina utilizados no presente estudo não foram suficientes para promover melhora na homeostase glicêmica de ratos diabéticos. Arq Bras Endocrinol Metab. 2012;56(1):25-32 Descritores Exercício; diabetes; Spirulina; ratos ABSTRACT Objective: The objective of this study was to analyze the effect of Spirulina and/or exercise training in the control of serum glucose homeostasis in diabetic rats. Materials and methods: Young Wistar rats were induced to diabetes by intravenous alloxan administration and separated into four groups: diabetic control (DC), diabetic Spirulina (DS), diabetic exercise (DE) and diabetic exercise Spirulina (DES). Results: There were no differences between groups with respect to: body weight, food intake, glucose tolerance, insulin tolerance and blood lactate concentrations during a swimming effort test. DS group showed lower insulin concentrations when compared with DC (pancreas) and DE and DES (serum). Conclusion: The protocols of exercise and supplementation with Spirulina used in the present study were not able to improve serum glucose homeostasis in diabetic rats. Arq Bras Endocrinol Metab. 2012;56(1):25-32 Keywords Exercise; diabetes; Spirulina; rats INTRODUÇÃO O diabetes melito (DM) é um problema de saúde públi-ca mundial. Estima-se que existam mais de 150 milhões de pessoas com essa doença no mundo, e projeções da Organização Mundial da Saúde (OMS) para 2025 suge rem que esse número possa chegar a 300 milhões (1).O DM é caracterizado pela redução da secreção (diabetes melito tipo 1 (DM1) -insulino-dependente) ou da ação da insulina (diabetes melito tipo 2 (DM2) -não insulino-dependente), acarretando hiperglicemia, além de alterações no metabolismo das proteínas e dos lipídeos (2). As consequências para o organismo são variadas, incluindo hipertensão, nefropatias, retinopatias e cardiopatias (3). Em consequência dos efeitos colaterais causados por agentes terapêuticos usados para o tratamento dessa patologia, como os hipoglicemiantes orais e a insulina (4), atualmente existe grande interesse nas ervas medicinais (5), como hipoglicemiantes naturais (6), entre elas a Spirulina (7).A Spirulina é uma alga verde-azulada de forma helicoidal, com comprimento de 0,2-0,5 mm (8),

Six-week anaerobic training improves proteolytic profile of diabetic rats

“…This loss can be associated with hypoinsulinemia that occurs due to this disease, generating a catabolic state of proteins and fats. Another contributing factor is as sociated to elevated glucose excretion observed in the animals (data not shown) and polyuria (20), as expec ted in this condition. On the other hand, when diabetic animals (DE) were submitted to anaerobic training, we detected a lower weight associated to higher reduction of fat mass associated to increased lean mass compared to the control groups (Table 2), suggesting the positive effect of training to avoid muscle proteolysis.…”

“…The reduction in the glycaemia in this condition can be jus tified by elevated glucose uptake by peripheral tissues, stimulated by contractile activity during the training (15). The training has provoked a hypoglycemic effect, which can be found in different studies involving ex perimental and clinical model of diabetes (20,21), however, few studies have focused on protocols using longterm anaerobic training. Various studies have fo cused on the training program involving aerobic exer cise and/or combined exercise (aerobic plus anaerobic exercise) (17,2123).…”

Effect of Spirulina Platensis on Some Serum Markers, Performance Metrics and Organ Weights, in Rats Fed with Hydrogenated Vegetable Oil and/or Cholesterol

“…Similarly, Araújo et al (2003) found that Spirulina added to the diet did not alter the body weight of the animals. Furthermore, Moura et al (2012) reported no difference in body weight between groups with and without addition of Spirulina. The addition of Spirulina to the diet did not affect body weight without showing any toxicity in rats (Salazar et al 1996).…”

The effects of spirulina intake on clinical and metabolic parameters in Alzheimer's disease: A randomized, double‐blind, controlled trial

“…Results from both clinical studies (Anitha & Chandralekha, 2010) and experimental (Joventino & Alves, 2012) proved the hypoglycemic effect of spirulina in diabetic animal models and subjects with type 2 diabetes mellitus. In addition, it was reported that spirulina has a beneficial effect on fasting insulin and glucose values (Moura et al, 2012). In a meta‐analysis, the favorable effects of spirulina intake on improving FPG, insulin, total‐, VLDL‐, LDL‐, and HDL‐cholesterol levels in subjects with metabolic syndrome and related disorders (Hamedifard et al, 2019).…”