Metabolic syndrome in children born small-for-gestational age

Hernández, María Isabel; Mericq, Verónica

doi:10.1590/s0004-27302011000800012

Cited by 43 publications

(31 citation statements)

References 58 publications

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“…In the present cohort, SGA obese children had increased CIMT, leptin and hsCRP, and decreased adiponectin, when compared to their obese AGA counterparts. Although the sample size is very small, the results strengthen the hypothesis that SGA babies are at higher risk of developing metabolic syndrome and its consequences (23), mainly due to a low-grade inflammatory state and to altered adipokines levels, independent of adiposity.…”

supporting

confidence: 67%

Metabolic syndrome in children and teenagers: worth assessing it, but how?

Filho

2017

Arch. Endocrinol. Metab.

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supporting

confidence: 67%

Metabolic syndrome in children and teenagers: worth assessing it, but how?

Filho

2017

Arch. Endocrinol. Metab.

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“…), non-alcoholic fatty liver disease and type 2 diabetes, is increased in children born SGA who have a rapid catch-up in weight compared with children born appropriate for gestational age [2]. Furthermore, the development of such chronic conditions increases the risk of cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Long-Term Growth Hormone Treatment on Metabolic Parameters in Japanese Patients with Short Stature Born Small for Gestational Age

et al. 2014

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Background/Aims: An examination of the effects of up to 260 weeks of growth hormone (GH) therapy on metabolic parameters in Japanese children born small for gestational age (SGA). Methods: Data were analysed from a 156-week extension of a 104-week multicentre, randomised, double-blind, parallel-group trial. Sixty-five children born SGA (age 3-<8 years) received 33 μg/kg/day (n = 31, 64.5% male) or 67 μg/kg/day (n = 34, 58.8% male) GH for 260 weeks. Changes in metabolic parameters - glucose, insulin, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol - were recorded. Alterations in weight, body mass index standard deviation score (BMI SDS) and vital signs were also evaluated. Results: Over 260 weeks of GH treatment, a positive correlation between Δheight SDS and Δinsulin-like growth factor-I SDS was observed. Insulin and glucose levels were generally unaffected. Favourable changes in lipid profiles were recorded, which were maintained for the study duration. No adverse alterations in weight, BMI SDS or vital signs were noted. Conclusion: Long-term, continuous GH treatment in children born SGA appears to be efficacious, associated with potential benefits for several metabolic parameters and associated with no long-term safety concerns.

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“…Most of these children show a catch-up growth during the first 2 years of life, but approximately 15% of them continue to be short throughout childhood, adolescence and into adulthood [1,2]. Subjects born SGA are at high risk of developing chronic diseases, including metabolic syndrome (MetS), which have been related to the intrauterine life environment and linked to epigenetic fetal programming [3]. Insulin resistance (IR) may be present as early as 1 year of age, and obesity and/or type 2 diabetes are more prevalent in children born SGA than those born appropriate for gestational age (AGA) [4].…”

Section: Introductionmentioning

confidence: 99%

Nonalcoholic Fatty Liver Disease in Prepubertal Children Born Small for Gestational Age: Influence of Rapid Weight Catch-Up Growth

Faienza¹,

Brunetti²,

Ventura³

et al. 2013

Horm Res Paediatr

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Background/Aims: We studied the association of low birth weight with ultrasound-assessed nonalcoholic fatty liver disease (NAFLD) to test the hypothesis that fetal growth retardation followed by a rapid weight catch-up growth might be an additional factor responsible for liver steatosis via insulin resistance (IR) and/or intra-abdominal fat. Methods: We enrolled 23 children born small for gestational age (SGA) with a rapid catch-up growth within the first 6-12 months, and 24 appropriate for gestational age (AGA) children as controls.All children underwent anthropometric, body composition measurements and evaluation of liver function tests, lipid profile, plasma glucose and insulin levels. Abdominal ultrasonography was performed in order to asses liver steatosis and thickness of subcutaneous and visceral adipose tissue. Results: NAFLD were observed in 8 out of the 23 SGA children (34.8%). IR and visceral fat were significantly increased in children with hepatic steatosis compared to those without. IR index was significantly related to liver steatosis, independently of body mass index standard deviation score and visceral fat. Conclusions: NAFLD should be recognized as an emerging problem in SGA prepubertal children who presented a rapid weight gain in postnatal life, and IR plays the key role. An appropriate diet during pregnancy and in the first year of life might prevent metabolic syndrome and NAFLD in these subjects.

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Metabolic syndrome in children born small-for-gestational age

Cited by 43 publications

References 58 publications

Metabolic syndrome in children and teenagers: worth assessing it, but how?

Metabolic syndrome in children and teenagers: worth assessing it, but how?

The Impact of Long-Term Growth Hormone Treatment on Metabolic Parameters in Japanese Patients with Short Stature Born Small for Gestational Age

Nonalcoholic Fatty Liver Disease in Prepubertal Children Born Small for Gestational Age: Influence of Rapid Weight Catch-Up Growth

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