Treinamento resistido reduz inflamação em músculo esquelético e melhora a sensibilidade à insulina periférica em ratos obesos induzidos por dieta hiperlipídica

Panveloski-Costa, Ana Carolina; Júnior, Danilo Antônio Corrêa Pinto; Brandão, Bruna B.; Moreira, Roger William Fernandes; Machado, Ubiratan Fabres; Seraphim, Patrícia Monteiro

doi:10.1590/s0004-27302011000200008

Cited by 11 publications

(12 citation statements)

References 41 publications

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“…After four weeks of exposure to this hyperlipidic diet, there was significant increase in body weight of the animals from the obese group and reduction in the insulin sensitivity when compared with the animals from the control group (figures 2 and 3), which only received standard chow as food, highlighting the obesogenic effect of the diet 22 and the correlation between obesity and metabolic alterations caused by fat excess 25 . The cytokines released by the excessive adipose tissue may generate a scenario of peripheral systemic inflammation 26,27 , altering the insulin signaling and initiating a possible insulin resistant status 28 .…”

Section: Discussionmentioning

confidence: 93%

“…Alimentos Ltda., São Leopoldo/RS; with composition of 25% of proteins, 3% of lipids, 18% of fibers, 11% of mineral material, 2% of calcium and 0.5% of phosphorus) and they were offered water ad libitum. The grou of obese rats was fed hyperlipidic diet composed of bacon, bologna, wieners, cookies, soda and standard chow, in a proportion of approximately 2:2:2:1:1:1, respectively, in a composition of 28% of carbohydrates, 13% of proteins and 59% of lipids, from the second month of life 22 . The animals were weekly weighed for follow-up of the body weight evolution.…”

Section: Obesity Inductionmentioning

confidence: 99%

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Uso do teste de duplos esforços para avaliação da capacidade aeróbia de ratos obesos induzidos por dieta

Brandão¹,

Souza²,

Trombetta³

et al. 2013

Rev Bras Med Esporte

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Introduction: The literature lacks studies about lactate actions and some limitations in studies involving healthy individuals or patients with some metabolic disorder. Objectives: This study aimed to evaluate the protocol of double effort test for obese-induced rats. Methods: Fourteen male Wistar rats were divided into two groups: Control (Con) and Obese (Obe). The control group was fed with standard chow and water ad libitum. The obese group was fed with standard chow, water ad libitum and hyperlipidic diet. Twelve weeks after the beginning of the hyperlipidic diet, insulin tolerance test, Maximal Lactate Steady State (MLSS) test and the double efforts test were performed. Results: The diet was effective to promote obesity. The obese group decreased insulin sensitivity in approximately 19% (Con = 2.156 ± 0.1187 AU vs Obe = 1.742 ± 0.1551 AU). The lactate concentration and velocity of anaerobic threshold at MLSS test were 3.780 ± 0.09 mmol/L e 18 m.min -1 in both groups. The velocity of anaerobic threshold estimated by double efforts test was 15.59±0.653 m.min -1 in Con group control animals and 16.42±0.672 m.min -1 in Obe group. The double effort test underestimated around 13% and 8.7% the aerobic capacity in control and obese groups respectively, however, presented significant correlation with MLSS (r = 0,88; P < 0,0075 controls / r = 0,92; P < 0,0031 obese). Conclusion: So, the double effort test can be an interesting alternative to evaluate the aerobic capacity for both healthy sedentary and obese animals.

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Section: Discussionmentioning

confidence: 93%

Section: Obesity Inductionmentioning

confidence: 99%

Uso do teste de duplos esforços para avaliação da capacidade aeróbia de ratos obesos induzidos por dieta

Brandão¹,

Souza²,

Trombetta³

et al. 2013

Rev Bras Med Esporte

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“…They suggest that low-to-moderate swimming training for a long duration reduces thermal hyperalgesia in diabetic rats. Panveloski-Costa et al 52 endeavored to determine if a resistive exercise protocol can modulate Tnf-α, SOCS3 and glucose transporter GLUT4 genes expression in skeletal muscle, and peripheral insulin sensitivity in obese rats induced by hyperlipidic diet. The mRNA content of Tnf-α and SOCS3 increased in skeletal muscle sedentary but decreased in exercised animals.…”

Section: Resultsmentioning

confidence: 99%

[ARTIGO RETRATADO] Exercício e suas interações com vários aspectos da vida do homem e dos animais

Gomes¹,

Rocha-e-Silva²

2012

Acta ortop. bras.

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To review recently published papers in the Brazilian Scientific press on the general subject of physical exercise. All articles published in 2010/2011 found through the keyword exercise were collected from 11 Brazilian Journals. They were hand filtered to exclude all but original research papers. They were grouped according to subject categories and subcategories. A brief summary of all included articles was produced, comparing similar articles between them. The most commonly found interactions refer to exercise vs. the cardiovascular system, metabolism and the locomotor system, in this order. The volume of scientific research in the field is high and of sufficient quality to justify highlighting.

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“…Nas últimas décadas, tem sido demonstrada a contribuição da inflamação para a manifestação do aumento de espécies reativas de oxigênio em pacientes obesos (VOLP et al, 2010). Os macrófagos presentes em tecido adiposo são importantes fontes de citocinas inflamatórias, particularmente nos tecidos subcutâneo e visceral (COSTA et al, 2011). O aumento deste tecido está associado à maior produção do TNF-α, IL-6, IL-8, leptina, fator ativador de plasminogênio 1 (PAI-1), além da diminuição da expressão de adiponectina que possui ação anti-inflamatória (CARVALHO; COLAÇO; FORTES, 2006).…”

Section: Obesidade Inflamação E Zincounclassified

Participação da inflamação sobre o metabolismo do zinco na obesidade

Feitosa¹,

Lima²,

Marreiro³

2012

Nutrire

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This review reports on aspects of zinc metabolism in obesity, as well as the participation of this mineral in disorders that are associated with the disease's pathophysiology. Inflammation, which is present in obese individuals, is directly related to zinc metabolism, and may increase zinc content in hepatocytes and adipocytes at the expense of zinc in blood components. It has been shown that high concentrations of glucocorticoids, which are usual in obese individuals, lead to reduced levels of zinc in plasma and an increased uptake of zinc by the liver. There is an inverse correlation between tumor necrosis factor a and zinc-α2-glycoprotein, which is considered a potential candidate in the modulation of body weight. In obese individuals, changes have also been observed in the compartmentalization of zinc and its relationship with adipocytokines, which are normally present at high concentrations in these patients. Therefore, it is important to understand the possible pathophysiological mechanisms, since zinc may contribute to the control of inflammatory and metabolic disorders that are commonly present in obese patients.

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Treinamento resistido reduz inflamação em músculo esquelético e melhora a sensibilidade à insulina periférica em ratos obesos induzidos por dieta hiperlipídica

Cited by 11 publications

References 41 publications

Uso do teste de duplos esforços para avaliação da capacidade aeróbia de ratos obesos induzidos por dieta

Uso do teste de duplos esforços para avaliação da capacidade aeróbia de ratos obesos induzidos por dieta

[ARTIGO RETRATADO] Exercício e suas interações com vários aspectos da vida do homem e dos animais

Participação da inflamação sobre o metabolismo do zinco na obesidade

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