Dificuldades e armadilhas no diagnóstico da síndrome dos ovários policísticos

Marcondes, José Antônio Miguel; Barcellos, Cristiano Roberto Grimaldi; Rocha, Marco

doi:10.1590/s0004-27302011000100002

Cited by 12 publications

(8 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The Ferriman and Gallwey scale presents low reproducibility with great interobserver variability, which may reach 50%, depending on the area being considered. 33 However, it is a widely used instrument in the clinical practice because it is easy to use and the costs involved are low. 34 The prevalence of MetS encountered in the present sample was 33.6%, with no statistically significant difference between the phenotypes.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Metabolic Syndrome in the Different Phenotypes of Polycystic Ovarian Syndrome

Tavares

Barros

2019

Rev Bras Ginecol Obstet

View full text Add to dashboard Cite

Objective To evaluate the prevalence of metabolic syndrome (MetS) in the phenotypes of polycystic ovarian syndrome (PCOS). Methods This was a cross-sectional study involving 111 women aged between 18 and 39 years old diagnosed with PCOS, according to the Rotterdam Criteria, and grouped into four phenotypes: A: ovulatory dysfunction + hyperandrogenism + polycystic ovaries; B: ovulatory dysfunction + hyperandrogenism; C: hyperandrogenism + polycystic ovaries; D: ovulatory dysfunction + polycystic ovaries. To evaluate the presence of MetS, we measured serum triglyceride levels, HDL cholesterol, fasting blood glucose, blood pressure, and waist circumference. Results The prevalence of MetS found in this sample was 33.6%, and there was no statistically significant difference (p < 0.05) among the 4 phenotypes. However, phenotype D presented a significantly higher mean glucose level after fasting (93.6 mg/dL) and 2 hours after ingesting a solution with 75 g of anhydrous glucose (120 mg/dL), as well as the lowest mean level of high-density lipoprotein (HDL) cholesterol (44.7 mg/dL). The women in this group demonstrated a high prevalence of abdominal circumference ≥ 80 cm (68.2%), as well as the highest mean abdominal circumference (90.1 cm). Amongst the women with an abdominal circumference ≥ 80 cm, phenotype A increased approximately six-fold the chance of developing metabolic syndrome in relation to phenotype C. Conclusion The four phenotypes of PCOS demonstrated similar prevalence rates of metabolic syndrome; abdominal obesity presented a relevant role in the development of metabolic alterations, regardless of the phenotype.

show abstract

Section: Discussionmentioning

confidence: 99%

The Prevalence of Metabolic Syndrome in the Different Phenotypes of Polycystic Ovarian Syndrome

Tavares

Barros

2019

Rev Bras Ginecol Obstet

View full text Add to dashboard Cite

show abstract

“…Polycystic ovary syndrome (PCOS) affects 1 in 15 women worldwide. It is a heterogeneous clinical condition, and is the commonest endocrine disorder at reproductive age, varying from 6–10%, according to diagnosing criteria ( 1 – 3 ). In Saudi Arabia, the prevalence of PCOS is still unknown, but it is believed that it might be similar to that of other reports ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with metabolic syndrome and cardiovascular disease among women with polycystic ovary syndrome in Tabuk, Saudi Arabia

2017

View full text Add to dashboard Cite

BackgroundPolycystic ovary syndrome (PCOS) is the commonest endocrine disorder at a reproductive age. It is associated with a high risk of metabolic syndrome (MS) and cardiovascular diseases (CVD).ObjectiveTo measure the prevalence of MS in women with PCOS and to assess the global cardiovascular risk (CVR) among them.MethodsThis cross-sectional study was conducted at King Khalid Hospital, Tabuk, Saudi Arabia during the period from February through December 2014. A total of 404 infertile women were randomly selected, and checked for diagnosing PCOS, MS and estimated CVD probability. Data were analyzed by IBM-SPSS version 22, using independent-samples t-test, Chi-square, and conditional logistic regression. A p-value of <0.05 was considered significant.ResultsMS was diagnosed in 58% and 32% of women with and without PCOS respectively (p<0.00). Results showed a statistically significant association between the two syndromes. Patients with the two syndromes showed high averages of clinical and biochemical values (p<0.00), high rate of predicted CVR, a high percentage of clustering of MS factors, and that weight-waist circumference - HDL are predictive for the occurrence of MS.ConclusionPCOS is associated with the risk of development of MS, and CVD. Screening for early detection of PCOS and MS and the application of cohort studies are recommended to better explore the role of PCOS in the development of CVD and to assess the significance of interventions.

show abstract

“…Subsequently, the heterogeneity of the clinical features led to the adoption of the term “polycystic ovary syndrome.” Following the introduction of new investigative techniques, such as hormone measurements by radioimmunoassay and ovarian morphology by ultrasound, the earlier diagnosis diagnosis based only on clinical and anatomical criteria was replaced by a new one which incorporates hormonal and ultrasonographic criteria [3]. …”

Section: Introductionmentioning

confidence: 99%

Metabolic Disturbance in PCOS: Clinical and Molecular Effects on Skeletal Muscle Tissue

Dantas

Gualano

Rocha

et al. 2013

The Scientific World Journal

View full text Add to dashboard Cite

Polycystic ovary syndrome is a complex hormonal disorder affecting the reproductive and metabolic systems with signs and symptoms related to anovulation, infertility, menstrual irregularity and hirsutism. Skeletal muscle plays a vital role in the peripheral glucose uptake. Since PCOS is associated with defects in the activation and pancreatic dysfunction of β-cell insulin, it is important to understand the molecular mechanisms of insulin resistance in PCOS. Studies of muscle tissue in patients with PCOS reveal defects in insulin signaling. Muscle biopsies performed during euglycemic hyperinsulinemic clamp showed a significant reduction in glucose uptake, and insulin-mediated IRS-2 increased significantly in skeletal muscle. It is recognized that the etiology of insulin resistance in PCOS is likely to be as complicated as in type 2 diabetes and it has an important role in metabolic and reproductive phenotypes of this syndrome. Thus, further evidence regarding the effect of nonpharmacological approaches (e.g., physical exercise) in skeletal muscle of women with PCOS is required for a better therapeutic approach in the management of various metabolic and reproductive problems caused by this syndrome.

show abstract

Dificuldades e armadilhas no diagnóstico da síndrome dos ovários policísticos

Cited by 12 publications

References 55 publications

The Prevalence of Metabolic Syndrome in the Different Phenotypes of Polycystic Ovarian Syndrome

The Prevalence of Metabolic Syndrome in the Different Phenotypes of Polycystic Ovarian Syndrome

Risk factors associated with metabolic syndrome and cardiovascular disease among women with polycystic ovary syndrome in Tabuk, Saudi Arabia

Metabolic Disturbance in PCOS: Clinical and Molecular Effects on Skeletal Muscle Tissue

Contact Info

Product

Resources

About