Hyperfunctioning thyroid cancer: a five-year follow-up

Azevedo, Monalisa F.; Casulari, Luíz Augusto

doi:10.1590/s0004-27302010000100013

Cited by 12 publications

(12 citation statements)

References 16 publications

(8 reference statements)

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“…Out of these 31 articles, 16 articles (five series of cases and 11 case reports) included cases matching the previously mentioned criteria for a total of 45 reported cases. 6,7,[11][12][13][14][15][16][17][18][19][20][21][22][23][24] Among these 45 cases, the histological repartition was as follow: 25 (56%) follicular carcinoma, 16 (36%) papillary carcinoma including at least four (9%) confirmed follicular variant, two (4%) Hürthle cells thyroid cancer, one (2%) poorly differentiated thyroid cancer and we were not able to find the histology for one case (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Thyroid Carcinoma in Hot Nodules: Review of the Literature

Iranmanesh¹,

Pusztaszeri²,

Robert³

et al. 2013

World Journal of Endocrine Surgery

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Thyroid hot nodules are virtually always considered benign. Rare cases of hot thyroid carcinoma exist. We briefly described a clinical case and performed a review of the literature. We performed an extensive research on medical databases, such as PubMed and compiled all published cases matching preset criteria defining true hot thyroid carcinomas as well as guidelines regarding their management. We analyzed 103 articles published over the past 50 years. We selected 16 articles, including 45 cases matching our criteria. The majority were follicular carcinomas. Papillary carcinomas were infrequently found in this setting. Recommended management and survival rates were similar to classical cold thyroid cancer. Although hot nodules should continue to be considered benign most of the time, rare cases of hot thyroid cancers exist and clinicians should not hesitate to ask for additional tests if they encounter any abnormal finding. This form of thyroid cancer can reasonably be managed the same way as the cold thyroid cancers.

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Section: Resultsmentioning

confidence: 99%

Thyroid Carcinoma in Hot Nodules: Review of the Literature

Iranmanesh¹,

Pusztaszeri²,

Robert³

et al. 2013

World Journal of Endocrine Surgery

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“…It characterizes as follicular architecture with nuclear features of papillary carcinoma. The nuclear features are subtle; histological interpretation is prone to intra-observer variation and, as such, mistaken for follicular adenoma [ 7 ]. In the review of the literature, we found the following cases of the follicular variant of thyroid carcinoma arising within a hot nodule (Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

Follicular Variant of Papillary Thyroid Carcinoma Presented as Autonomous Functioning Thyroid Nodule: A Case Report and Review of Literature

Shahbaz¹,

Alkomos²,

Mahendhar³

et al. 2018

Cureus

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Follicular variant of papillary thyroid carcinoma (FVPTC) presented as an autonomous functioning thyroid nodule is a rare finding. We reported a case of 70-year-old male presented with complaints of palpitation and heat intolerance. On palpation, we found a thyroid nodule of 4 cm in the left lobe. Thyroid function tests revealed hyperthyroidism, and radioactive iodine uptake scan (RAIU) showed increased uptake in the left lobe consistent with a hot nodule. The probability of the benign nature of hyperfunctioning thyroid nodule discussed but patient requested further workup to rule out any remote possibility of thyroid cancer. We performed a fine needle aspiration (FNA), and the cytological examination suggested the possibility of thyroid carcinoma. The patient underwent total thyroidectomy, and histological examination revealed follicular architecture with nuclear features of papillary carcinoma in 1 cm area of the thyroid nodule. In the review of the literature, we identified the following seven cases of FVPTC arising within a hyperfunctioning thyroid nodule.

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“…One study showed a 2.8% incidence of hyperthyroidism among patients with thyroid malignancy in an iodine-deficient area. [ 4 ] The reported sites of autonomous hyperfunctioning thyroid cancer are either at the primary site at the thyroid bed, which is seen as a hot nodule on thyroid scintigraphy,[ 1 5 6 7 8 9 ] or at a metastatic site. [ 10 11 12 13 14 15 ] Some reported the mechanism of activated receptors on the cancer cells with high level of TSH-binding inhibitory immunoglobulin and thyroid stimulating antibody in the absence of thyroid tissue, occurred in metastatic site after the completion of radioiodine treatment for many years.…”

Section: Discussionmentioning

confidence: 99%

A case report of hyperfunctioning metastatic thyroid cancer and rare I-131 avid liver metastasis

2016

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Thyroid cancer is usually, relatively hypofunctional; most patients with thyroid cancer are clinically euthyroid. The combination of thyroid cancer and thyrotoxicosis is not common. We herein, report a case of follicular thyroid cancer with hyperfunctioning metastasis in a 43-year-old woman who presented with thyrotoxicosis, a cold right thyroid nodule, and low I-131 uptake at the thyroid bed. An additional total body scan with I-131 revealed a large radioiodine avid osteolytic bone metastasis with soft tissue masses and liver metastasis. The patient received treatment with total thyroidectomy, methimazole, and I-131 at a cumulative dose of 600 mCi along with recombinant human thyroid-stimulating hormone before the first I-131 treatment and palliative radiation. The patient had normal liver function test and experienced a mild degree of bone marrow suppression after I-131. At the 2-year follow-up, the patient was still alive with the progression of bone metastases but was doing well with less severe thyrotoxicosis, good ambulation, and an Eastern Cooperative Oncology Group performance status of 2. Clinicians should be aware of the unusual concurrent presentation of thyrotoxicosis and thyroid cancer, a differential diagnosis in patients with thyrotoxicosis and low or normal radioiodine uptake over the neck and also potential pitfalls during radionuclide treatment.

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Hyperfunctioning thyroid cancer: a five-year follow-up

Cited by 12 publications

References 16 publications

Thyroid Carcinoma in Hot Nodules: Review of the Literature

Thyroid Carcinoma in Hot Nodules: Review of the Literature

Follicular Variant of Papillary Thyroid Carcinoma Presented as Autonomous Functioning Thyroid Nodule: A Case Report and Review of Literature

A case report of hyperfunctioning metastatic thyroid cancer and rare I-131 avid liver metastasis

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