Contribuição da análise de textura do núcleo celular para o diagnóstico diferencial de lesões foliculares da tireoide: comparação com marcadores imunoistoquímicos

Ferreira, Rita de Cássia Café; Ward, Laura Sterian; Adam, Randall L.; Leite, Neucimar J.; Metze, Konradin; Matos, Patrícia Francisca de

doi:10.1590/s0004-27302009000700003

Cited by 3 publications

(1 citation statement)

References 17 publications

(23 reference statements)

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“…Several TA studies show good discrimination of thyroid nodules on ultrasound images (13–15) and better distinction between benign and malignant thyroid lesions on nuclear chromatin images (16), but none have utilized TA on DW-MRI scans of the thyroid. The aim of this study was to assess whether textural analysis could improve the accuracy, sensitivity, and specificity of DW-MRI for the stratification of malignancy in suspicious thyroid nodules.…”

Section: Introductionmentioning

confidence: 99%

Multi‐institutional validation of a novel textural analysis tool for preoperative stratification of suspected thyroid tumors on diffusion‐weighted MRI

Brown

Nagala

McLean

et al. 2015

Magnetic Resonance in Med

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Purpose Ultrasound-guided fine-needle-aspirate-cytology (FNAC) fails to diagnose many malignant thyroid nodules; thus, patients may undergo diagnostic lobectomy. This study assessed whether textural analysis (TA) could non-invasively stratify thyroid nodules accurately using diffusion-weighted (DW) MRI. Methods This multi-institutional study examined 3T DW-MRI images obtained with spin-echo echo-planar-imaging (DW-EPI) sequences. The training dataset included 26 patients from Cambridge, UK and test dataset included 18 thyroid cancer patients from Memorial Sloan-Kettering, USA. Apparent diffusion coefficients (ADCs) were compared over regions-of-interest (ROIs) defined on thyroid nodules. TA, linear discriminant analysis (LDA), and feature reduction using the 21 MaZda-generated texture parameters that best distinguished benign and malignant ROIs. Results Training dataset mean ADC values were significantly different for benign and malignant nodules (p=0.02) with sensitivity and specificity of 70% and 63%, respectively, and receiver-operator-characteristic (ROC) area-under-the-curve (AUC) of 0.73. The LDA model of the top 21 textural features correctly classified 89/94 DW-MRI ROIs with 92% sensitivity, 96% specificity, and AUC of 0.97. This algorithm correctly classified 16/18 (89%) patients in the independently obtained test set of thyroid DW-MRI scans. Conclusion TA classifies thyroid nodules with high sensitivity and specificity on multi-institutional DW-MRI datasets. This method needs further validation in a larger prospective study.

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Section: Introductionmentioning

confidence: 99%

Multi‐institutional validation of a novel textural analysis tool for preoperative stratification of suspected thyroid tumors on diffusion‐weighted MRI

Brown

Nagala

McLean

et al. 2015

Magnetic Resonance in Med

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Chromatin changes in papillary thyroid carcinomas may predict patient outcome

et al. 2012

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Both gender and concurrent chronic lymphocytic thyroiditis may influence the nuclear texture of papillary thyroid carcinomas cells

Cunha¹,

Ferreira²,

Matos³

et al. 2014

Endocrine Research

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A disparity in gender incidence has been reported in both papillary thyroid carcinoma (PTC) and chronic lymphocytic thyroiditis (CLT) diseases frequently associated and whose incidence has been increasing in parallel. We aimed to analyze differences in morphometric variables between male and female PTC patients and their relationship with the presence of concurrent CLT. The nuclear texture features of 100 hematoxylin-eosin stained nuclei from 100 consecutive classic PTC patients enrolled in our service were compared with their clinical and pathological features, including the presence of CLT. All patients were submitted to a standard management protocol and followed-up for 13-248 months (Mo = 117 months). Chromatin in women tended to present a denser and more homogeneous structure, in a less mottled pattern, with higher values of energy (p = 0.008) and diagonal moment (p = 0.032) than men. Concurrent CLT was more prevalent in women (41.42%) than in men (13.33%, p = 0.04) and was associated with higher cluster prominence values (p = 0.027), a parameter that indicates a predominance of high nuclear contrasted heterochromatin. A multivariate logistic regression analysis showed that higher cluster prominence was independently correlated with chromatin in patients who presented CLT but did not demonstrate any association between concurrent CLT and gender. We were unable to demonstrate any association between gender and any characteristic of tumor aggressiveness or patients outcome. Our results suggest that chromatin texture of hematoxylin-eosin stained nuclei in paraffin sections of PTC cells is related to both gender and concurrent CLT.

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Contribuição da análise de textura do núcleo celular para o diagnóstico diferencial de lesões foliculares da tireoide: comparação com marcadores imunoistoquímicos

Cited by 3 publications

References 17 publications

Multi‐institutional validation of a novel textural analysis tool for preoperative stratification of suspected thyroid tumors on diffusion‐weighted MRI

Multi‐institutional validation of a novel textural analysis tool for preoperative stratification of suspected thyroid tumors on diffusion‐weighted MRI

Chromatin changes in papillary thyroid carcinomas may predict patient outcome

Both gender and concurrent chronic lymphocytic thyroiditis may influence the nuclear texture of papillary thyroid carcinomas cells

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