2009
DOI: 10.1590/s0004-27302009000600003
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Abstract: RNA splicing is an essential, precisely regulated process that occurs after gene transcription and before mRNA translation, in which introns may be removed and exons, retained. Variability in splicing patterns is a major source of protein diversity from the genome and function to generate a tremendously diverse proteome from a relatively small number of genes. Após a transcrição genética e antes da tradução do mRNA, ocorre o splicing do RNA, que consiste em um processo essencial, precisamente regulado, por mei… Show more

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“…As such, they have been used as biomarkers and therapy targets . For example, specific protein isoforms have been shown to impact thyroid pathological conditions , they are involved in various types of cancer , multiple sclerosis , heart hypertrophy , autoimmune diseases , and in diabetes as well as in the regulation of embryonic stem cell pluripotency and reprograming . Yet, the exact roles of most splice variants/isoforms are still poorly understood.…”
Section: Introductionmentioning
confidence: 99%
“…As such, they have been used as biomarkers and therapy targets . For example, specific protein isoforms have been shown to impact thyroid pathological conditions , they are involved in various types of cancer , multiple sclerosis , heart hypertrophy , autoimmune diseases , and in diabetes as well as in the regulation of embryonic stem cell pluripotency and reprograming . Yet, the exact roles of most splice variants/isoforms are still poorly understood.…”
Section: Introductionmentioning
confidence: 99%