Vitamina D e doenças endocrinometabólicas

Schuch, Natielen Jacques; Garcia, Vinícius Cardoso; Martini, Lígia Araújo

doi:10.1590/s0004-27302009000500015

Cited by 56 publications

(37 citation statements)

References 67 publications

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“…According to the study, the association of these with the lack of sun exposure may increase the risk of fractures by increasing bone loss and the propensity for falls. 16 In addition to this, recent studies have shown that vitamin D deficiency is related to other pathologies such as cancer, diabetes melittus 17 and cardiovascular processes, such as hypertension and atherosclerosis. 18 Observational studies demonstrate such associations, but interventional studies, for the most part, fail to demonstrate the benefit of reducing such outcomes.…”

Section: Discussionmentioning

confidence: 98%

Prevalence of hypovitaminosis D in institutionalized elderly

Paiva¹,

Bettinelli²,

Pasqualotti³

et al. 2017

Mundo da Saúde

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A insuficiência de vitamina D acomete aproximadamente 1 bilhão de pessoas no mundo, tornando-se um problema de saúde pública. Ela causa alterações no crescimento e desenvolvimento ósseo em crianças e osteomalácia e osteoporose em adultos e idosos. A vitamina D permite a mineralização óssea normal e mobiliza cálcio do osso para o sangue. Sua deficiência aumenta o risco de quedas na velhice e, consequentemente, o risco de fraturas e/ ou outros problemas de saúde. Considerando as informações apresentadas, o estudo transversal prospectivo, com amostragem probabilística, teve como objetivo avaliar a prevalência de hipovitaminose D em idosos institucionalizados em Passo Fundo/RS. Participaram do estudo 77 idosos. Mediram-se os níveis de 25-hidroxivitamina D, relacionando-os com dados socioeconômicos e demográficos, medicamentos e hábitos diários. Os dados foram coletados entre os meses de junho a agosto de 2011. Houve prevalência de hipovitaminose D em 97% da amostra estudada. A deficiência acentuada de vitamina D esteve apenas associada estatisticamente com os níveis de albumina (p = 0,048). Evidenciou-se correlação negativa entre os níveis séricos de 25(OH)D e PTH (rs = -0,240, p = 0,033). Evidencia-se alta prevalência de hipovitaminose D na população idosa institucionalizada. Os profissionais de saúde e cuidadores devem tomar medidas de caráter interdisciplinar que minimizem esse problema de saúde pública. Vitamin D deficiency affects approximately one billion people around the world, making it a public health problem. It causes changes in growth and bone development in children and osteomalacia and osteoporosis in adults and elderly. Vitamin D makes possible normal bone mineralization and bone calcium mobilization into the blood. The deficiency of it increases the risk of falls in the elderly and, consequently, the risk of fractures and/or other health problems. Considering the information presented, the prospective cross-sectional study with probability sampling, aimed to determine the prevalence of hypovitaminosis D in institutionalized elderly in Passo Fundo/RS. 77 elderly patients participated in the study. The levels of 25-hydroxyvitamin D were measured and were associated with the socioeconomic and demographic data, medication and daily habits. The data were collected between June to August 2011. There was a prevalence of hypovitaminosis D among 97% of the sample. A noticeable deficiency of vitamin D was only statistically associated with albumin levels (p = 0.048). It was also evident that there was a negative correlation between the serum levels of 25 (OH) D and the parathyroid hormone PTH (rs = -0.240, p = 0.033). There is a high prevalence of hypovitaminosis D among institutionalized elderly. Health professionals and caregivers should take interdisciplinary measures that minimize this public health problem. Palavras-chave:

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Section: Discussionmentioning

confidence: 98%

Prevalence of hypovitaminosis D in institutionalized elderly

Paiva¹,

Bettinelli²,

Pasqualotti³

et al. 2017

Mundo da Saúde

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“…Além disso, foram observados menores níveis séricos de 25 (OH) D entre aqueles com excesso de peso, obesidade abdominal e hipercolesterolemia [41]. Essa relação pode ser justificada pelo depósito de 25 (OH) D nos adipócitos, diminuindo sua biodisponibilidade e desencadeando uma cascata de reações hormonais que resultam em aumento da fome e diminuição do gasto energético [42]. Em adolescentes obesos, baixas concentrações de vitamina D também têm sido associadas com níveis reduzidos de HDL-c [43] e elevados de triglicerídeos e do índice homeostatic model assessment para resistência à insulina (HOMA-IR) [44].…”

Section: Discussionunclassified

Consumo alimentar e síndrome metabólica em adolescentes

Assis

Novaes

Cândido

et al. 2017

Sci Med

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Este artigo está licenciado sob forma de uma licença Creative Commons Atribuição 4.0 Internacional, que permite uso irrestrito, distribuição e reprodução em qualquer meio, desde que a publicação original seja corretamente citada. http://creativecommons.org/licenses/by/4.0/deed.pt_BR Consumo alimentar e síndrome metabólica em adolescentes ABSTRACT Aims:To determine the prevalence of metabolic syndrome in adolescents and to compare the dietary intake of individuals with and without the syndrome. Methods: A cross-sectional study was conducted with adolescents aged 15 to 17 years, enrolled in public and private schools in Juiz de Fora, Minas Gerais, Brazil. Body mass index was used to determine the nutritional status, classified according to the World Health Organization. Waist circumference was measured according to Petroski (2003). Triglyceride, high-density lipoprotein cholesterol, fasting blood glucose, and blood pressure were assessed and the International Diabetes Federation criteria were used for the diagnosis of metabolic syndrome. A non-consecutive 3-day food record was used for dietary assessment. The chi-square test, Fisher's exact test, Student's parametric t test or the Mann-Whitney U test were used for associations between the groups. Results: A total of 302 adolescents -51.99% males and 73.51% from public schools -were evaluated. The prevalence of obesity was 27.48% and that of metabolic syndrome was 3.97%; 4.83% among girls and 3.18% among boys (p=0.46). The prevalence of metabolic syndrome among public school students was 4.50% compared with 2.50% (p=0.73) among those from private schools. In the comparison between the groups with and without metabolic syndrome, there were no statistically significant differences in dietary energy and micronutrient adequacy, except for vitamin D (p=0.01). Adolescents with metabolic syndrome consumed less vitamin D than those without the syndrome. Conclusions:The prevalence of metabolic syndrome was found to be relevant considering its complexity, severity, and the age group studied. Lower vitamin D intake was observed among adolescents with metabolic syndrome.

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“…The association between vitamin D and diabetes mellitus is explained by the following: a) the discovery of receptors of vitamin D (VDR) and 1α-hydroxylase enzyme inside beta cells; b) calcium-linking protein vitamin D-dependent (DBP) in the pancreatic tissue; and c) increase in the association between acquired and innate immunity [16].…”

Section: Pathophysiologymentioning

confidence: 99%

“…With a sufficient level of 25-hydroxy vitamin D > 30 ng/mL, occurs the decrease of 1,25(OH)2D3 and the PTH induces the entrance of calcium in the cells core in the muscular tissues, adipose tissue and pancreatic cells (via the calcium canal), which stimulate signal transduction and activation of the glucose 4 transporter (GLUT4) for better insulin response [16].…”

Section: Pathophysiologymentioning

confidence: 99%