Identification of occult metastases of medullary thyroid carcinoma by calcitonin measurement in washout fluid from fine needle aspiration of cervical lymph node

Siqueira, Débora Rodrigues; Rocha, Andreia Possatti da; Puñales, Márcia Khaled; Maia, Ana Luiza Silva

doi:10.1590/s0004-27302009000400016

Cited by 7 publications

(11 citation statements)

References 9 publications

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“…The review of the titles and abstracts of these papers led to the exclusion of many records according to the above‐mentioned criteria. Eight articles were finally selected and their full‐text versions retrieved . Another four additional studies were found by screening the references of these papers .…”

Section: Resultsmentioning

confidence: 99%

“…Another four additional studies were found by screening the references of these papers . Altogether 12 studies were included in our review . Papers were published from 2007 and 2014, one was multicenter (Italy‐Switzerland), nine were set as single‐center and retrospective (one from Switzerland, one from Japan, one from United States, and six from Italy), and two were case reports (one from Brazil and one from Turkey).…”

Section: Resultsmentioning

confidence: 99%

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Use of fine‐needle aspirate calcitonin to detect medullary thyroid carcinoma: A systematic review

Trimboli

Guidobaldi

Bongiovanni³

et al. 2015

Diagnostic Cytopathology

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The present study shows that the above ATA recommendation is well supported. Almost all MTC lesions are correctly detected by FNA-calcitonin and this technique should be used to avoid false negative or inconclusive results from cytology. The routine determination of serum calcitonin in patients undergoing FNA should improve the selection of patients at risk for MTC, guiding the use of FNA-calcitonin in the same FNA sample and providing useful information to the cytopathologist for the morphological assessment and the application of tailored ancillary tests.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Use of fine‐needle aspirate calcitonin to detect medullary thyroid carcinoma: A systematic review

Trimboli

Guidobaldi

Bongiovanni³

et al. 2015

Diagnostic Cytopathology

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“…In such cases it is prudent to recommend serum calcitonin levels to establish the diagnosis of medullary carcinoma (138,144,145). Some authors have also suggested measuring calcitonin levels in the FNAB rinse to diagnose primary and recurrent/metastatic MTC as an adjunct to cytomorphology (146,147).…”

Section: B Amentioning

confidence: 99%

C-cells and their associated lesions and conditions: a pathologists perspective

Baloch¹,

LiVolsi²

2015

TJPATH

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This paper updates the histopathology and cytopathology of thyroid tumors and proliferations derived from the para-follicular or C cells. Beginning with an historical over view, including the recognition of medullary thyroid carcinoma as a distinct histologic entity, its relationship to the hormone, calcitonin, (which was discovered in the same decade) and to thyroid C cells, medullary carcinoma and its variants are reviewed. The molecular biology of the tumors and the associated mutations in the tumors (somatic mutations) are discussed. Additionally the genetic features (germline mutations) including familial clusters and associations with other endocrine and neuroendocrine lesions are reviewed. Screening for the tumor and its precursors is included with a review of the latest American Thyroid Association guidelines for treatment as well as timing and approach to surgery. Tabular data of specific germline mutations and their relationships to tumor virulence, and prognosis are illustrated. Precursor and early C cell lesions such as C-cell hyperplasia and micro-medullary carcinoma are discussed. Difficulties and controversies in the definition of C-cell proliferations which are neoplastic and those which are "reactive" are reviewed. The entity of medullary microcarcinoma or medullary microcarcinoma is illustrated and the distinction between C cell nodules and microcarcinoma is defined using the latest available criteria. Finally the latest approved chemotherapeutic agents and their results in metastatic medullary thyroid carcinoma are included.

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“…The measurement of calcitonin in the washout fluid has been recommended to improve the diagnostic sensitivity of FNAB for MTC (22,23) (B/C). In a recent retrospective study, the cytology detected MTC in 21/37 lesions with 56.8% sensitivity whereas the measurement of calcitonin in the washout fluid showed sensitivity and specificity rates of 100% using a cutoff of 36 pg/mL (24) (B).…”

Section: (B)mentioning

confidence: 99%

Diagnóstico, tratamento e seguimento do carcinoma medular de tireoide: recomendações do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e Metabologia

Maia

Siqueira

Kulcsar

et al. 2014

Arq Bras Endocrinol Metab

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Introduction: Medullary thyroid carcinoma (MTC) originates in the thyroid parafollicular cells and represents 3-4% of the malignant neoplasms that affect this gland. Approximately 25% of these cases are hereditary due to activating mutations in the REarranged during Transfection (RET) proto-oncogene. The course of MTC is indolent, and survival rates depend on the tumor stage at diagnosis. The present article describes clinical evidence-based guidelines for the diagnosis, treatment, and follow-up of MTC. Objective: The aim of the consensus described herein, which was elaborated by Brazilian experts and sponsored by the Thyroid Department of the Brazilian Society of Endocrinology and Metabolism, was to discuss the diagnosis, treatment, and follow-up of individuals with MTC in accordance with the latest evidence reported in the literature. Materials and methods: After clinical questions were elaborated, the available literature was initially surveyed for evidence in the MedLine-PubMed database, followed by the Embase and Scientific Electronic Library Online/Latin American and Caribbean Health Science Literature (SciELO/Lilacs) databases. The strength of evidence was assessed according to the Oxford classification of evidence levels, which is based on study design, and the best evidence available for each question was selected. Results: Eleven questions corresponded to MTC diagnosis, 8 corresponded to its surgical treatment, and 13 corresponded to follow-up, for a total of 32 recommendations. The present article discusses the clinical and molecular diagnosis, initial surgical treatment, and postoperative management of MTC, as well as the therapeutic options for metastatic disease. Conclusions: MTC should be suspected in individuals who present with thyroid nodules and family histories of MTC, associations with pheochromocytoma and hyperparathyroidism, and/or typical phenotypic characteristics such as ganglioneuromatosis and Marfanoid habitus. Fine-needle nodule aspiration, serum calcitonin measurements, and anatomical-pathological examinations are useful for diagnostic confirmation. Surgery represents the only curative therapeutic strategy. The therapeutic options for metastatic disease remain limited and are restricted to disease control. Judicious postoperative assessments that focus on the identification of residual or recurrent disease are of paramount importance when defining the follow-up and later therapeutic management strategies. Arq Bras Endocrinol Metab. 2014;58(7):667-700

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Identification of occult metastases of medullary thyroid carcinoma by calcitonin measurement in washout fluid from fine needle aspiration of cervical lymph node

Cited by 7 publications

References 9 publications

Use of fine‐needle aspirate calcitonin to detect medullary thyroid carcinoma: A systematic review

Use of fine‐needle aspirate calcitonin to detect medullary thyroid carcinoma: A systematic review

C-cells and their associated lesions and conditions: a pathologists perspective

Diagnóstico, tratamento e seguimento do carcinoma medular de tireoide: recomendações do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e Metabologia

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