Increase incidence of thyroid cancer in Florianopolis, Brazil: comparative study of diagnosed cases in 2000 and 2005

Abstract

Objective: To provide epidemiological information about thyroid cancer (TC) in the Metropolitan area of Florianopolis and investigate some factors that could be associated with this type of cancer. Method: This study analyzed data of patients who had TC diagnosed and underwent surgical treatment in 2000 and 2005. Epidemiological factors about patients, tumors and surgical procedures were evaluated. Results: In 2000 and 2005, an increasing incidence of TC at a rate of 132.33% was detected. The increased rate was mainly observed for tumors measuring less than 1 cm (p = 0.004). Results also showed an increase in the number of multifocal tumors (p = 0.02) and in the rate of total thyroidectomy (p = 0.002). Conclusions: The increasing incidence of TC in the Metropolitan area of Florianopolis is probably due to more invasive thyroid nodule management. Future studies are necessary to establish potential predicting factors for papillary thyroid microcarcinoma aggressiveness, as well as predictors of follicular lesion malignancy to identifying more accurately the appropriate therapy approach. Arq Bras Endocrinol Metab. 2009;53(4):453-60. KeywordsThyroid neoplasm; incidence; early diagnosis rEsUMO Objetivo: Fornecer informações epidemiológicas acerca do câncer de tireoide (CT) na Grande Florianópolis e avaliar fatores que possam estar associados a tal neoplasia. Métodos: A população de estudo incluiu pacientes, com diagnóstico de CT, submetidos a tratamento cirúrgico em 2000 e 2005. Foram avaliados fatores epidemiológicos referentes aos pacientes, características das lesões e procedimentos cirúrgicos realizados. Resultados: Durante o período de estudo, detectou-se um aumento na incidência do CT correspondente a 132,33%. Verificouse um incremento estatisticamente significativo dos tumores menores de um centímetro (p = 0,004), da proporção de tumores multicêntricos (p = 0,02) e de tireoidectomias totais (p = 0,002). Conclusões: A maior incidência do CT na Grande Florianópolis está possivelmente associada a uma conduta mais intervencionista na abordagem de nódulos tireoidianos. Estudos futuros se fazem necessários para o estabelecimento de critérios preditivos da agressividade dos microcarcinomas papilíferos e de malignidade das lesões foliculares no sentido de identificar com acurácia a melhor opção terapêutica. Arq Bras Endocrinol Metab. 2009;53(4):453-60.

Increasing incidence of differentiated thyroid cancer in South East England: 1987–2006

“…This study demonstrates a significant increase in the incidence of thyroid cancer in SE England between 1987 and 2006, which is consistent with the findings worldwide [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16]. Females are about three times likely to develop thyroid cancer in SE England.…”

“…Several studies have confirmed the increasing incidence of differentiated thyroid cancer in the USA [2][3][4][5], Europe [6][7][8][9][10][11][12], Canada [13], Brazil [14], Australia [15] and Saudi Arabia [16].…”

Evolution of thyroid cancer mortality in adults in Brazil

“…Several epidemiological studies suggest this scenario as a result of improvements in the accuracy of diagnostic methods and increased sensitivity to find cases, with the widespread use of cervical ultrasound and fine needle aspiration cytology (9)(10)(11)(12). Moreover, it is believed that the increase in incidence is not exclusively related to diagnostic methods, but due to risk factors (13,14).…”

Cumulative doses of radioiodine in the treatment of differentiated thyroid carcinoma: knowing when to stop

“…Arq Bras Endocrinol Metab. 2010;54(9):807-12 Descritores Dose cumulativa; radioiodoterapia; iodeto-131 I; carcinoma diferenciado de tiroide INTRODUCTION D ifferentiated thyroid cancer incidence has been rising all over the world and recent data demonstrate that rates have also increased for large and aggressive tumors diagnosed with distant metastasis (SEER stage) (1)(2)(3). Standard treatment for DTC patients includes total or near-total thyroidectomy followed by adjuvant radioiodine therapy (RIT) to destroy remnant, benign or malignant thyroid tissue (4)(5)(6).…”