Dietary glycemic load, glycemic index, and refined grains intake are associated with reduced β-cell function in prediabetic Japanese migrants

Sartorelli, Daniela Saes; Franco, Laércio Joel; Damião, Renata; Gimeno, Suely Godoy Agostinho; Cardoso, Marly Augusto; Ferreira, Sandra Roberta Gouvêa

doi:10.1590/s0004-27302009000400007

Cited by 10 publications

(3 citation statements)

References 22 publications

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“…Compared with the refined grains (such as white rice), the coarse cereals were low in glycemic index (GI) and rich in fiber may lower the risk of diabetes [ 46 ]. It was suggested that high intakes of refined grains intake and usual diets with high GL diet were associated with reduced β-cell function in pre-diabetic Japanese-Brazilians [ 47 ]. The updated analyses from three large US cohorts and meta analyses provide evidence that higher dietary GI and GL are associated with increased risk of diabetes, participants who consumed diets with high GI or high GL and low cereal fiber had a nearly 40% higher risk of compared with those whose diets were high in cereal fiber and low in GI or GL [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Associations between Dietary Patterns and Impaired Fasting Glucose in Chinese Men: A Cross-Sectional Study

Zhang

Zhu

et al. 2015

Nutrients

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Few studies have examined the association between Asian dietary pattern and prediabetes, in particular, the Chinese diet. We conducted a cross-sectional study to identify dietary patterns associated with impaired fasting glucose (IFG) which considered a state of prediabetes in Chinese men. The study included 1495 Chinese men aged 20 to 75 years. Information about diet was obtained using an 81-item food frequency questionnaire (FFQ), and 21 predefined food groups were considered in a factor analysis. Three dietary patterns were generated by factor analysis: (1) a vegetables-fruits pattern; (2) an animal offal-dessert pattern; and (3) a white rice-red meat pattern. The multivariate-adjusted odds ratio (OR) of IFG for the highest tertile of the animal offal-dessert pattern in comparison with the lowest tertile was 3.15 (95% confidence intervals (CI): 1.87–5.30). The vegetables-fruits dietary pattern was negatively associated with the risk of IFG, but a significant association was observed only in the third tertile. There was no significant association between IFG and the white rice-red meat pattern. Our findings indicated that the vegetables-fruits dietary pattern was inversely associated with IFG, whereas the animal offal-dessert pattern was associated with an increased risk of IFG in Chinese men. Further prospective studies are needed to elucidate the diet-prediabetes relationships.

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Section: Discussionmentioning

confidence: 99%

Associations between Dietary Patterns and Impaired Fasting Glucose in Chinese Men: A Cross-Sectional Study

Zhang

Zhu

et al. 2015

Nutrients

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“…More specifically, for example, refined grains and grains with high GL and GI have been reported to increase the risk of onset of diabetes. 17,21,33 Results of the European Prospective Investigation into Cancer and Nutrition-Netherlands (EPIC-NL) study have shown that the risk of diabetes increases with an increase of carbohydrate intake, and that starch abundantly contained in grains and potatoes is the only carbohydrate food item that has shown a significant correlation with the risk of diabetes among all carbohydrate food items. 34 Based on these findings, carbohydrate intake should be examined further from the aspects of, not only energy ratio, but also quality.…”

Section: Discussionmentioning

confidence: 99%

Optimal energy distribution of carbohydrate intake for Japanese elderly patients with type 2 diabetes: The Japanese Elderly Intervention Trial

Kamada

Yoshimura

Okumura

et al. 2012

Geriatrics Gerontology Int

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Aim:In diet therapy for diabetes, optimal energy intake and the energy distribution of macronutrients (protein : fat : carbohydrate [PFC] energy ratio) are important. We aimed to clarify the correlation between the PFC energy ratio and metabolic parameters including glycated hemoglobin A1c (HbA1c) and triglycerides in Japanese elderly patients with type 2 diabetes mellitus aged 65 years or older.Methods: Participants were 1173 diabetic patients aged 65 years or older with serum HbA1c level of м7.4% enrolled in the Japanese Elderly Diabetes Intervention Trial (J-EDIT). The participants were divided into four groups by the percentage of total energy intake (%E) of carbohydrate (C1: less than 55%E, C2: 55%E or more and less than 60%E, C3: 60%E or more and less than 65%E, and C4: 65%E or more). Relations of %E of carbohydrate to HbA1c and other metabolic parameters, energy intake and nutritional intake were examined. Furthermore, the subjects were divided into four categories by HbA1c levels by quartile method (Q1: less than 7.90%, Q2: 7.90% or more and less than 8.30%, Q3: 8.30% or more and less than 8.80%, Q4: 8.80% or more). Relations of HbA1c to other metabolic parameters, energy intake and nutritional intake were examined. Results:The mean HbA1c levels in the four groups were C1: 8.40%, C2: 8.50%, C3: 8.41% and C4: 8.36% in men, and C1: 8.51%, C2: 8.47%, C3: 8.35% and C4: 8.52% in women, respectively. There were no significant differences and linear trend in HbA1c levels across groups. The mean triglyceride levels were in the range of 122-128 mg/dL in men from C1 to C3, although it was significantly higher in C4 (177 mg/dL). The mean triglyceride levels were in the range of 128-136 mg/dL in women from C1 to C3, although it was significantly higher in Q4 (150 mg/dL). Amounts of protein and fat intakes decreased with an increase of %E of carbohydrate, although amount of carbohydrate intake did not change significantly. As a result, %E of protein and fat, and energy intake decreased in both men and women with an increase in %E of carbohydrate. Among the four quartiles divided by HbA1c levels, there were no significant differences in energy intake and PFC energy ratio. Conclusions:The present study suggests that, within the range studied, the carbohydrate energy ratio has no correlation with HbA1c levels. However, serum triglyceride levels increased and high-density lipoprotein cholesterol levels decreased significantly, with an increase of %E of carbohydrate in men, and the same tendencies were observed in women. Furthermore, in patients with 65%E or more of carbohydrate, serum triglyceride levels exceeded 150 mg/dL, which is the recommended treatment target for diabetic patients. These results suggest that the ideal %E of carbohydrate for Japanese elderly type 2 diabetes is less than 65. The lower limit of %E of carbohydrate could not be determined from the present study. Geriatr Gerontol Int 2012; 12 (Suppl. 1): 41-49.

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“…Dyslipidemia is challenging with pancreatic β dysfunction cells in subjects with NGT and this is especially seen in people with elevated TC and LDL-C levels, especially men [9]. Beta-cell function and insulin sensitivity were significantly improved through a low-fat plant-based diet in overweight adults [21].Dietary glycemic load, glycemic index, and refined grains intakes are associated with reduced β-cell function, and the quality of dietary carbohydrates may be relevant for maintaining β-cell function among individuals [22]. Besides food intake factor, consumption of antihyperlipidemia drugs is very influential on beta cell damage.…”

Section: Resultsmentioning

confidence: 99%

Correlation Between Lipid Profiles with Pancreatic β-Cell Function in Patients with Type 2 Diabetes Mellitus

Sarbini¹,

Huriyati²,

Sadewa³

et al. 2020

Proceedings of the 4th International Symposium on Health Research (ISHR 2019)

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Type 2 Diabetes Mellitus (T2DM) is characterized by 2 times higher blood glucose and lipid profile than nondiabetic people. Several studies indicated that pancreatic β cell dysfunction due to dyslipidemia is an independent risk factor T2DM. Dyslipidemia on T2DM can lead pancreatic β cell dysfunction. Objective: This study aimed to determine the correlation between lipid profiles (triglyceride, total cholesterol, LDL, and HDL) with pancreatic β cell function (HOMA-β) in patients with T2DM. Methods: This research method is a crosssectional study of 50 patients with T2DM at Community Health Center (45-65 years old). Lipid profiles level were analized by glycerol-3-phosphate-oxidase (GPO) PAP method (Genius) and insulin level was analized by using ELISA. β cell function is measured using HOMA-β. Pearson Correlation test was used to assess the correlation between lipid profiles with HOMA-β (p value <0.05) Results: This study showed no significant relationship between triglyceride and HOMA-β (p= 0,430), total cholesterol with HOMA-β (p=0,717), LDL with HOMA-β (p=0,633), HDL with HOMA-β (p=0,754). There is no significant relationship between lipid profiles (triglyceride, total cholesterol, LDL, and HDL) and β cell function. For further research, it is recommended to examine other factors such as food intake by taking into account the drugs consumed.

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Dietary glycemic load, glycemic index, and refined grains intake are associated with reduced β-cell function in prediabetic Japanese migrants

Abstract: These data suggested that dietary glycemic load, glycemic index, and refined grains intakes are associated with reduced beta-cell function, and the quality of dietary carbohydrates may be relevant for maintaining beta-cell function among individuals with IGT.

Cited by 10 publications

References 22 publications

Associations between Dietary Patterns and Impaired Fasting Glucose in Chinese Men: A Cross-Sectional Study

Associations between Dietary Patterns and Impaired Fasting Glucose in Chinese Men: A Cross-Sectional Study

Optimal energy distribution of carbohydrate intake for Japanese elderly patients with type 2 diabetes: The Japanese Elderly Intervention Trial

Correlation Between Lipid Profiles with Pancreatic β-Cell Function in Patients with Type 2 Diabetes Mellitus

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