[RETRACTION]Translational research into gut microbiota: new horizons in obesity treatment

Tsukumo, Daniela Miti Lemos; Carvalho, Bruno; Carvalho-Filho, Marco Antônio de; Saad, Mário José Abdalla

doi:10.1590/s0004-27302009000200004

Cited by 34 publications

(10 citation statements)

References 17 publications

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“…Several mechanisms have been proposed to link gut flora to obesity, including the role of the gut microbiota in increasing energy extraction from indigestible dietary polysaccharides [101] and elevating plasma lipopolysaccharide levels, resulting in chronic low-grade inflammation [102]. …”

Section: Gut Microbiotamentioning

confidence: 99%

Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids

Estadella

Nascimento

Oyama

et al. 2013

Mediators of Inflammation

145

100

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The ingestion of excessive amounts of saturated fatty acids (SFAs) and transfatty acids (TFAs) is considered to be a risk factor for cardiovascular diseases, insulin resistance, dyslipidemia, and obesity. The focus of this paper was to elucidate the influence of dietary SFA and TFA intake on the promotion of lipotoxicity to the liver and cardiovascular, endothelial, and gut microbiota systems, as well as on insulin resistance and endoplasmic reticulum stress. The saturated and transfatty acids favor a proinflammatory state leading to insulin resistance. These fatty acids can be involved in several inflammatory pathways, contributing to disease progression in chronic inflammation, autoimmunity, allergy, cancer, atherosclerosis, hypertension, and heart hypertrophy as well as other metabolic and degenerative diseases. As a consequence, lipotoxicity may occur in several target organs by direct effects, represented by inflammation pathways, and through indirect effects, including an important alteration in the gut microbiota associated with endotoxemia. Interactions between these pathways may perpetuate a feedback process that exacerbates an inflammatory state. The importance of lifestyle modification, including an improved diet, is recommended as a strategy for treatment of these diseases.

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Section: Gut Microbiotamentioning

confidence: 99%

Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids

Estadella

Nascimento

Oyama

et al. 2013

Mediators of Inflammation

145

100

View full text Add to dashboard Cite

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“…2009; Tsukumo et al . 2009). LAB and bifidobacterial populations have been detected as part of the complex intestinal ecosystem in the majority of humans, even though species composition is highly subject-specific (Turnbaugh and Gordon 2009).…”

Section: Fermented Food Microbiotamentioning

confidence: 99%

Antibiotic resistance determinants in the interplay between food and gut microbiota

2011

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A complex and heterogeneous microflora performs sugar and lactic acid fermentations in food products. Depending on the fermentable food matrix (dairy, meat, vegetable etc.) as well as on the species composition of the microbiota, specific combinations of molecules are produced that confer unique flavor, texture, and taste to each product. Bacterial populations within such “fermented food microbiota” are often of environmental origin, they persist alive in foods ready for consumption, eventually reaching the gastro-intestinal tract where they can interact with the resident gut microbiota of the host. Although this interaction is mostly of transient nature, it can greatly contribute to human health, as several species within the food microbiota also display probiotic properties. Such an interplay between food and gut microbiota underlines the importance of the microbiological quality of fermented foods, as the crowded environment of the gut is also an ideal site for genetic exchanges among bacteria. Selection and spreading of antibiotic resistance genes in foodborne bacteria has gained increasing interest in the past decade, especially in light of the potential transferability of antibiotic resistance determinants to opportunistic pathogens, natural inhabitants of the human gut but capable of acquiring virulence in immunocompromised individuals. This review aims at describing major findings and future prospects in the field, especially after the use of antibiotics as growth promoters was totally banned in Europe, with special emphasis on the application of genomic technologies to improve quality and safety of fermented foods.

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“…However, some other factors like mental stress, infection and genetic predisposition might lead to diabetes as well [1]-[4]. Both obesity and diabetes are characterized by a state of chronic low-grade inflammation with abnormal expression and production of multiple inflammatory mediators such as tumor necrosis factor and interleukins [5].…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

et al. 2010

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BackgroundRecent evidence suggests that there is a link between metabolic diseases and bacterial populations in the gut. The aim of this study was to assess the differences between the composition of the intestinal microbiota in humans with type 2 diabetes and non-diabetic persons as control.Methods and FindingsThe study included 36 male adults with a broad range of age and body-mass indices (BMIs), among which 18 subjects were diagnosed with diabetes type 2. The fecal bacterial composition was investigated by real-time quantitative PCR (qPCR) and in a subgroup of subjects (N = 20) by tag-encoded amplicon pyrosequencing of the V4 region of the 16S rRNA gene. The proportions of phylum Firmicutes and class Clostridia were significantly reduced in the diabetic group compared to the control group (P = 0.03). Furthermore, the ratios of Bacteroidetes to Firmicutes as well as the ratios of Bacteroides-Prevotella group to C. coccoides-E. rectale group correlated positively and significantly with plasma glucose concentration (P = 0.04) but not with BMIs. Similarly, class Betaproteobacteria was highly enriched in diabetic compared to non-diabetic persons (P = 0.02) and positively correlated with plasma glucose (P = 0.04).ConclusionsThe results of this study indicate that type 2 diabetes in humans is associated with compositional changes in intestinal microbiota. The level of glucose tolerance should be considered when linking microbiota with metabolic diseases such as obesity and developing strategies to control metabolic diseases by modifying the gut microbiota.

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[RETRACTION]Translational research into gut microbiota: new horizons in obesity treatment

Cited by 34 publications

References 17 publications

Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids

Lipotoxicity: Effects of Dietary Saturated and Transfatty Acids

Antibiotic resistance determinants in the interplay between food and gut microbiota

Gut Microbiota in Human Adults with Type 2 Diabetes Differs from Non-Diabetic Adults

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