Contribuição da apnéia obstrutiva do sono para o estresse oxidativo da obesidade

Lima, Anna Myrna Jaguaribe de; Franco, Clélia Maria Ribeiro; Castro, Célia Maria Machado Barbosa de; Bezerra, Alice de Andrade; Ataíde, Luiz; Halpern, Alfredo

doi:10.1590/s0004-27302008000400013

Cited by 12 publications

(12 citation statements)

References 32 publications

(28 reference statements)

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“…Lima et al 17 observed the same hypoxic effect in patients with sleep apnea compared to healthy individuals, and similar data were obtained by Peled et al 12 .…”

Section: Discussionsupporting

confidence: 74%

Big Endothelin-1 and Nitric Oxide in Hypertensive Elderly Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome

Anunciato¹,

Lobo²,

Coelho³

et al. 2013

Arquivos Brasileiros De Cardiologia

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BackgroundThe role of oxidative stress in hypertensive elderly patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) is unknown. ObjectiveThe purpose was to evaluate the levels of big endothelin-1 (Big ET-1) and nitric oxide (NO) in elderly hypertensive patients with and without moderate to severe OSAHS. MethodsVolunteers were hospitalized for 24 h. We obtained the following data: body mass index (BMI); 24-ambulatory blood pressure monitoring; and current medication. Arterial blood was collected at 7pm and 7am for determining plasma NO and Big ET-1 levels. Pulse oximetry was performed during sleep. Pearson's or Spearman's correlation and univariate analysis of variance were used for statistical analysis. ResultsWe studied 25 subjects with OSAHS (group 1) and 12 without OSAHS (group 2) aged 67.0 ± 6.5 years and 67.8 ± 6.8 years, respectively. No significant differences were observed between the groups in BMI; number of hours of sleep; 24-h systolic and diastolic BPs; awake BP, sleep BP and medications to control BP between groups. No differences were detected in plasma Big ET-1 and NO levels at 19:00 h, but plasma Big ET-1 levels at 7:00 h were higher in group 1 (p = 0.03). In group 1, a negative correlation was also observed between the mean arterial oxyhemoglobin saturation level, 24-h systolic BP (p = 0.03, r = −0.44), and Big ET-1 (p = 0.04, r = −0.41). ConclusionsOn comparing elderly hypertensive patients with and without OSAHS having similar BP and BMI, we observed higher Big ET-1 levels After sleep in the OSAHS group. NO levels did not differ between the hypertensive patients with or without OSAHS.

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“…Lima et al 17 observed the same hypoxic effect in patients with sleep apnea compared to healthy individuals, and similar data were obtained by Peled et al 12 .…”

Section: Discussionsupporting

confidence: 74%

Big Endothelin-1 and Nitric Oxide in Hypertensive Elderly Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome

Anunciato¹,

Lobo²,

Coelho³

et al. 2013

Arquivos Brasileiros De Cardiologia

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“…[31][32][33] In analyzing the BQ scores, we found that the individuals with obesity participating in the multidisciplinary preoperative preparation program for bariatric surgery at Hospital de Clínicas -Unicamp were at a high risk (80.34%) of developing OSAS, versus 19.66% at low risk, thus confirming that obesity is a disease clearly identified as a risk factor for the development of OSAS. Pinto et al, 34 pointed out controversy as to which are the most significant predictive parameters of obesity leading to this association.…”

Section: Discussionmentioning

confidence: 67%

“…1,28 In OSAS, apnea and hypopnea lead to hypoxia and hypoxia-reoxygenation states, which, in turn, causes an inflammatory process and oxidative stress and, in combination with obesity, favors the formation of atheroma plaques. [29][30][31] In our study, we found that 53.8% of obese individuals have systemic arterial hypertension (SAH).…”

Section: Discussionmentioning

confidence: 99%

Obstructive sleep apnea syndrome among obese individuals: A cross-sectional study

Modena

Cazzo

Cândido

et al. 2017

Rev. Assoc. Med. Bras.

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Introduction: The obstructive sleep apnea syndrome (OSAS) is a respiratory illness, characterized by recurrent episodes of apnea and hypopnea, leading to reduction or cessation of the airflow. Obesity is one of the major risk factors for the development of OSAS. To help in the diagnosis of this disease, easily applicable and low-cost questionnaries were developed, such as the Berlin Questionnaire (BQ). Objective: To evaluate the efficacy of the BQ for the screening of OSAS among candidates to bariatric surgery in a multidisciplinary preoperative program. Method: This is an observational, descriptive and cross-sectional study which evaluated obese individuals that were being prepared for bariatric surgery by means of the BQ. Results: BQ was able to detect that minimal variations in the body mass index, neck circumference and hip-to-waist ratio lead to changes in the risk to develop OSAS; the higher the values of these variables, the higher the risk for OSAS development. Conclusion: BQ was an efficient and reliable tool to demonstrate the high risk for OSAS development in individual with obesity.

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“…Higher BMI is associated with increased oxidative stress, independently of other parameters such as OSA [34]. …”

Section: Discussionmentioning

confidence: 99%

Biochemical oxidative stress-related markers in patients with obstructive sleep apnea

et al. 2011

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SummaryBackgroundObstructive sleep apnea (OSA) is a condition contributing to oxidative stress. The aim of this study was to ascertain if there is any connection between OSA and novel oxidative stress-related markers. Matrix metalloproteinases 2 and 9 (MMP-2, MMP-9), high sensitive C-reactive protein (hsCRP), pregnancy-associated plasma protein-A (PAPP-A), soluble receptors for advanced glycation end-products (sRAGE), zinc (Zn) and copper (Cu) were measured. Further biochemical markers were evaluated.Material/MethodsFifty-one men suspected for OSA indicated for night polygraphy were included. Apnea/hypopnea index (AHI), oxygen desaturation index (ODI), mean blood hemoglobin oxygen saturation (SpO2) and time of blood hemoglobin oxygen saturation below 90% (SpO2 <90%) were measured. Morning venous blood samples were taken.ResultsFor body mass index (BMI) we found strong positive correlation with levels of Cu, MMP-9, hsCRP and fibrinogen, and negative correlation with sRAGE. Concerning ventilation parameters, we found positive correlation of ODI and SpO2 <90% with markers MMP-9 and hsCRP. sRAGE level correlated with AHI and ODI negatively. SpO2 correlated negatively with Cu, MMP-9, hsCRP and fibrinogen. There was no correlation between ventilation parameters and markers MMP-2, PAPP-A and Zn. Compared to severity of OSA, there was significant difference in levels of hsCRP and Cu between patients with AHI ≤5 and AHI ≥30 independent of BMI.ConclusionsMMP-9, hsCRP, sRAGE and Cu seem to be strong predictors of oxidative stress in OSA patients. The strong correlation between oxidative stress-related markers and OSA is elucidated by connection of these to BMI, which is probably a primary condition of oxidative stress, but OSA is an additive condition.

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Contribuição da apnéia obstrutiva do sono para o estresse oxidativo da obesidade

Cited by 12 publications

References 32 publications

Big Endothelin-1 and Nitric Oxide in Hypertensive Elderly Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome

Big Endothelin-1 and Nitric Oxide in Hypertensive Elderly Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome

Obstructive sleep apnea syndrome among obese individuals: A cross-sectional study

Biochemical oxidative stress-related markers in patients with obstructive sleep apnea

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