2008
DOI: 10.1590/s0004-27302008000200026
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Abstract: Glycemic control and diabetes duration are believed to be the most important risk factors for the development of diabetic microangiopathy; however, the rate of progression of nephropathy, retinopathy and polyneuropathy varies considerably among patients. Besides the presence of risk factors such as hypertension, dyslipidaemia and smoking, there is evidence suggesting that genetic predisposition plays a role in the susceptibility to microvascular complications. Based on underlying pathogenesis, polymorphisms of… Show more

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Cited by 10 publications
(2 citation statements)
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“…The evidence suggests that genetic susceptibility may play a major role in the development of microvascular complications, besides the presence of such risk factors as hyperglycaemia, hypertension, dyslipidaemia and smoking. Based on underlying pathogenesis, polymorphisms of several candidate genes belonging to multiple pathways have been investigated, like the genes related to mechanisms of hyperglycaemia-induced damage (such as advanced glycation end-products and reactive oxygen species increased formation, augmented activity of the aldose reductase pathway); genes related to the renin-angiotensin system; genes coding for cytokines, growth factors and its receptors, glucose transporters; among many others [ 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…The evidence suggests that genetic susceptibility may play a major role in the development of microvascular complications, besides the presence of such risk factors as hyperglycaemia, hypertension, dyslipidaemia and smoking. Based on underlying pathogenesis, polymorphisms of several candidate genes belonging to multiple pathways have been investigated, like the genes related to mechanisms of hyperglycaemia-induced damage (such as advanced glycation end-products and reactive oxygen species increased formation, augmented activity of the aldose reductase pathway); genes related to the renin-angiotensin system; genes coding for cytokines, growth factors and its receptors, glucose transporters; among many others [ 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…Apenas 0,1% da sequência do genoma difere entre os seres humanos e grande parte dessas diferenças relaciona-se a polimorfismos, que são variações do genoma presentes em mais de 1% da população total. Dentre os polimorfismos, a troca, inserção ou deleção de um único nucleotídeo no DNA é a forma mais comum, sendo essas alterações denominadas SNPs (single nucleotide polymorphisms) (4) .…”
Section: Introductionunclassified