2007
DOI: 10.1590/s0004-27302007000800027
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Abstract: Glucocorticoids have a major role in determining adipose tissue metabolism and distribution. 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) is a NADPHdependent enzyme highly expressed in the liver and adipose tissue. In most intact cells and tissues it functions as a reductase (to convert inactive cortisone to active cortisol). It has been hypothesized that tissue-specific deregulation of cortisol metabolism may be involved in the complex pathophysiology of the metabolic syndrome (MS) and obesity. Transgeni… Show more

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Cited by 22 publications
(17 citation statements)
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References 48 publications
(52 reference statements)
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“…164 However, patients with Cushing syndrome had levels of 11β-HSD1 mRNA similar to those of lean controls and lower than those of obese individuals, possibly because of downregulation from chronic hypercortisolemia. 151,165 11β-HSD1 expression is also induced by leptin and proinflammatory cytokines. Thus, the increases in local or systemic proinflammatory cytokines seen in obesity may further enhance adiposity by increasing 11β-HSD1 expression and local generation of GCs.…”
Section: β-Hsd1 As a Gatekeeper For Intracellular Gc Availabilitymentioning
confidence: 99%
“…164 However, patients with Cushing syndrome had levels of 11β-HSD1 mRNA similar to those of lean controls and lower than those of obese individuals, possibly because of downregulation from chronic hypercortisolemia. 151,165 11β-HSD1 expression is also induced by leptin and proinflammatory cytokines. Thus, the increases in local or systemic proinflammatory cytokines seen in obesity may further enhance adiposity by increasing 11β-HSD1 expression and local generation of GCs.…”
Section: β-Hsd1 As a Gatekeeper For Intracellular Gc Availabilitymentioning
confidence: 99%
“…As obesity increases in men and women, there is overexpression and increased activation of 11b-hydroxysteroid dehydrogenase (Paulsen et al, 2007) within local adipose tissue [independent of plasma cortisol levels (Espindola-Antunes and Kater, 2007)], which accentuates intracellular cortisol production and further upregulation of aromatase. In turn, circulating cortisol levels increase, which affects the development of dysmorphic features, central obesity, raised blood pressure, insulin resistance and dyslipidaemia.…”
Section: The Process In Detailmentioning
confidence: 99%
“…TAG in circulation, as components of both very low-density lipoproteins and chylomicrons, when hydrolyzed, release fatty acids that can be taken up by the surrounding tissues for use or storage, mainly in liver, muscle and central adipocytes 34 . GC promote the differentiation of adipose stromal cells to mature adipocytes, increasing visceral fat accumulation 34 and redistributing adipose tissue from peripheral to central depots, and increasing the size and number of fat cells 17,35 . Adenosine monophosphate activated protein kinase (AMPK) is a sensor of cellular energy status and is activated in response to a decrease of this state.…”
Section: Metabolic Syndromementioning
confidence: 99%
“…Tissue-specific dysregulation of GC metabolism seems to be involved in the complex pathophysiology of obesity and the MS 35 . In fact, 11β-HSD1 expression positively correlates with obesity and insulin resistance 35 .…”
Section: β-Hsd1 Rolementioning
confidence: 99%
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