Apo B/Apo A-I ratio in central and peripheral arterial diseases

Abstract

Background: The apo B/apo A-I ratio represents the balance between atherogenic particles, rich in apo B, and the antiatherogenic ones, apo A-I rich. This study investigated the association between atherosclerotic diseases in different anatomical sites and apo B/apo A-I ratio. Methods: Lipids, lipoproteins, and apolipoproteins A-I and B were assessed in 30 subjects with coronary artery disease (CAD), 26 with ischemic stroke (IS), 30 with peripheral arterial obstructive disease (PAOD), and 38 healthy subjects (controls). Results: HDLc and Apo A-I were significantly lower in PAOD and CAD groups, respectively, than in other groups. Significantly higher levels of triglycerides were observed for CAD and PAOD groups than for controls. Apo B was significantly higher in IS group than in control and PAOD groups. The apo B/apo A-I ratio showed significantly higher in CAD and IS groups when compared to control and PAOD groups (p < 0.001). Conclusion: The apo B/apo A-I ratio was important for identifying an increased trend for coronary and cerebral atherosclerosis. In spite of the increased trend for apo B/apo A-I ratio in IS and CAD groups, the studied variables cannot be considered in an isolated way, given as those parameters were analyzed together by a binary logistic regression, no association has been demonstrated.

Apolipoprotein A-I and B levels in Bangladeshi patients with coronary artery disease

“…Similar observation was also reported by other. 12 It is to be noted that the levels of serum apolipoproteins seem to be lower in Indian population as compared to those reported from the West. 8 Our data suggests that apart from measuring conventional lipid profile to ascertain the risk of coronary artery disease, it is also essential to estimate serum Apo A-I, Apo B and Apo B/A1 ratio.…”

Hypoglycemic effect of poly-herbal combination in streptozotocin-induced diabetic rats

“…Current reports suggest that cholesterol balance, determined as the apoB/apoA-I ratio has repeatedly been shown as a better marker than lipids, lipoproteins and lipid ratios (Lima et al, 2007). As shown in Figure 3, G-400 treatment significantly reduced apo B/apo A ratio, indicates the efficacy of the drug as a hypolipidemic agent as well.…”

“…The elevated apoprotein A, an integral protein of HDL and declined apoprotein B, an integral apoprotein of LDL in G-400 treated rat blood signify the antiatherogenic effect of the drug as previous study showed that apoB/apoA-I ratio represents the balance of proatherogenic and antiatherogenic lipoproteins (Lima et al, 2007). Current reports suggest that cholesterol balance, determined as the apoB/apoA-I ratio has repeatedly been shown as a better marker than lipids, lipoproteins and lipid ratios (Lima et al, 2007).…”

Argan Oil Exerts an Antiatherogenic Effect by Improving Lipids and Susceptibility of LDL to Oxidation in Type 2 Diabetes Patients

“…The diabetic patients in this study present a tendency to decrease the Apo B/Apo AI ratio after argan oil intervention, while they have showed an elevated Apo B/Apo AI ratio at baseline as in patients with metabolic syndrome, coronary artery disease, and with ischemic stroke [54, 55]. …”