2007
DOI: 10.1590/s0004-27302007000100007
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Abstract: RESUMODiversas alterações endócrinas são descritas na obesidade. O eixo corticotrófico encontra-se hiper-responsivo, com maior depuração dos hormônios e nível de cortisol normal. A caracterização do pseudo-Cushing é importante. A leptina parece ser um hormônio permissivo para o desencadeamento da puberdade. Em adultos, as gonadotrofinas são normais, hiperandrogenismo e hiperestrogenismo são encontrados. Nas mulheres, a resistência insulínica é central no desenvolvimento da síndrome dos ovários policísticos (SO… Show more

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Cited by 22 publications
(14 citation statements)
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“…The reasons for the association between metabolic syndrome and hypogonadism are not completely clear. It has been suggested that insulin resistance, acting through signs mediated by the adipose tissue, including increased levels of leptin, would have a direct role in the regulation of gonadal function, thus decreasing the concentrations of testosterone (1,4,25,26). At the same time, pro-inflammatory cytokines, such as TNF alpha, IL-1 and IL-6, produced by visceral adipocytes, are also associated with insulin resistance (27,28).…”
Section: Discussionmentioning
confidence: 99%
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“…The reasons for the association between metabolic syndrome and hypogonadism are not completely clear. It has been suggested that insulin resistance, acting through signs mediated by the adipose tissue, including increased levels of leptin, would have a direct role in the regulation of gonadal function, thus decreasing the concentrations of testosterone (1,4,25,26). At the same time, pro-inflammatory cytokines, such as TNF alpha, IL-1 and IL-6, produced by visceral adipocytes, are also associated with insulin resistance (27,28).…”
Section: Discussionmentioning
confidence: 99%
“…In the gonado-trophic axis, metabolic syndrome is associated with a state of male hypogonadism, whose origin and precise physiopathological mechanisms are still unknown (1,4).…”
mentioning
confidence: 99%
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“…Fat tissue is considered a large steroid deposit and the enzymatic reaction responsible for converting androgens into estrogens occurs in men as well as women, turning obesity into a risk factor for the development of breast cancer, due to the fact that fat is estrogenic (21) .…”
mentioning
confidence: 99%
“…Diversas evidências na literatura demonstram que o eixo hipotalámo-hipófise-adrenal (HHA) apresenta-se hiper-responsivo em indivíduos obesos, principalmente naqueles com distribuição central de gordura (8,9). Na obesidade, é descrito um aumento do clearance metabólico do cortisol que levaria a um maior estímulo do eixo HHA (10).…”
Section: Obesidadeunclassified