Distribuição centrípeta da gordura corporal, sobrepeso e aptidão cardiorrespiratória: associação com sensibilidade insulínica e alterações metabólicas

Abstract

The purpose of this paper was to investigate associations between the centripetal distribution of the body fat and serum lipid-lipoproteins, blood pressure and the index Homa-IR of insulin resistance, adjusting for indicators of overweight and cardiorespiratory fitness. Eighty-nine voluntaries were analyzed (44 men and 45 women). The centripetal distribution of the body fat was analyzed through waist circumference (CC) and the overweight by the body mass index (BMI). The cardiorespiratory fitness was followed by the estimate VO(2)max by test of walking. After adjusted for BMI values were found significant coefficient of correlation between CC and levels of blood pressure and ApoB in men, and between CC and index Homa-IR and triglycerides in women. After adjusted for VO(2)max values were verified significant correlations between CC and ApoB and index Homa-IR in men, and between CC and index Homa-IR in women. In conclusion, depending on the sex, the quantity and distribution of the body fat can present different actions in the insulin resistance and associated dysfunctions. The cardiorespiratory fitness per se seems not to contribute on the minimization of the association between the centripetal distribution of the body fat and the index Homa-IR; but presents a considerable impact on the association between the centripetal distribution of the body fat and the lipid metabolism and the levels of blood pressure, mainly in men.

Hyperinsulinism assessment in a sample of prepubescent children

“…Já Pivatto et al 18 e da Silva et al 21 não encontraram diferenças significativas entre os sexos quanto aos valores de HOMA-IR, sendo que, no primeiro estudo, também não foram encontradas diferenças em relação aos níveis séricos de insulina. Esses dois estudos foram realizados em indivíduos adultos.…”

“…No presente estudo, não foram avaliadas as diferenças do HOMA-IR entre os sexos, como feito nos estudos anteriormente citados 9,13,18,21 , já que as amostras foram obtidas na fase pré-púbere.…”

Avaliação do hiperinsulinismo em amostra de crianças pré-puberes

“…In contrast, neither Pivatto et al 18 nor da Silva et al 21 detected significant differences between the sexes for HOMA-IR and the first of these studies also failed to detect differences in terms of serum insulin levels. Both of these studies were with adults.…”

“…It therefore appears that there is currently a consensus that In a study published by Silva et al, 21 correlation coefficients suggested a significant association between BMI and IR. The findings of this study support their results since there was also a significant association between BMI and HOMA-IR.…”

“…4 21 Since male pattern obesity (greater deposition of fat in the abdominal region) has a strong association with metabolic disorders, it is important to investigate body fat distribution and its relationship with the etiology of hyperinsulinism. 4 Under normal conditions, insulin performs several functions in lipid metabolism regulation.…”