O sistema endocanabinóide: novo paradigma no tratamento da síndrome metabólica

Godoy-Matos, Amélio F.; Guedes, Erika Paniago; Souza, Luciana Lopes de; Valério, Cynthia Melissa

doi:10.1590/s0004-27302006000200025

Cited by 10 publications

(5 citation statements)

References 52 publications

(113 reference statements)

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“…Further to CB1 receptors being most abundant in the cerebral cortex, hippocampus, hypothalamus, cerebellum, spinal cord, dorsal cord ganglia, they are also found in the enteric nervous system, adipocytes, endothelial cells, hepatocytes, muscle, and gastrointestinal system. Conversely, CB2 receptors are found in the immune system as part of T and B cells, spleen, tonsils, and activated microglial cells [ 51 ] (Fig. 1 ).…”

Section: Main Textmentioning

confidence: 99%

The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans

et al. 2022

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Zebrafish is considered an unprecedented animal model in drug discovery. A review of the literature presents highlights and elucidates the biological effects of chemical components found in Cannabis sativa. Particular attention is paid to endocannabinoid system (eCB) and its main receptors (CB1 and CB2). The zebrafish model is a promising one for the study of cannabinoids because of the many similarities to the human system. Despite the recent advances on the eCB system, there is still the need to elucidate some of the interactions and, thus, the zebrafish model can be used for that purpose as it respects the 3Rs concept and reduced time and costs. In view of the relevance of cannabinoids in the treatment and prevention of diseases, as well as the importance of the zebrafish animal model in elucidating the biological effects of new drugs, the aim of this study was to bring to light information on the use of the zebrafish animal model in testing C. sativa-based medicines.

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Section: Main Textmentioning

confidence: 99%

The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans

et al. 2022

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“…Os receptores CB 1 são abundantes no cerebelo, região responsável pela coordenação dos movimentos do corpo; no hipocampo, responsável pela aprendizagem, memória e resposta ao stress e, no córtex cerebral, responsável pelas funções cognitivas. Os receptores colinérgicos nicotínicos possuem a capacidade de controlar a transmissão sináptica, pois atuam como mediadores da neurotransmissão excitatória rápida, estudos demonstram que os canabinóides atuam como antagonistas desses receptores, se mostrando eficaz para a redução das crises epilépticas (GODOY-MATOS et al, 2006).…”

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Eficácia do uso de Canabidiol em pacientes pediátricos com epilepsia refratária ao tratamento: uma revisão sistemática

Santos¹,

Gandara²,

Moser³

2022

PIC

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A epilepsia é um distúrbio neurológico crônico, caracterizado por crises epilépticasespontâneas e recorrentes, a qual pode atingir todas as idades. Alguns pacientes podemapresentar resistência aos fármacos antiepilépticos convencionais, que afetam odesenvolvimento e diretamente na sua qualidade de vida. Esta situação crítica levou a umabusca por soluções adicionais, como o uso dos canabinóides. O presente trabalho trata-se deuma revisão sistemática da literatura para avaliar a eficácia do canabidiol no tratamento deepilepsias refratárias em pacientes pediátricos. Para isto foram realizadas buscas nas basesde dados Cochrane, EBSCO e Biblioteca Virtual em Saúde (BVS) utilizando os seguintesdescritores: “Refractory Epilepsy” e “Cannabidiol”, empregado o conector “AND/E”, nosidiomas: inglês, espanhol e português. Os artigos foram selecionados por dois pesquisadorese ao final da seleção foram analisados 25 artigos. Foram extraídas e avaliadas as seguintesinformações: idade dos participantes, tipo de epilepsia, dosagem do canabidiol, redução donúmero e/ou intensidade das crises e efeitos adversos. Quanto à frequência das crises,quatorze estudos apresentaram pacientes que obtiveram 100% da diminuição das crises,entretanto a grande maioria de todos os participantes envolvidos tiveram reduções menores(19% - 99%). Três estudos evidenciaram que tiveram reduções menores que 50% nafrequência das crises. Em relação às doses utilizadas, não foi observado um padrão tendouma variação de 1 a 50 mg/kg/dia. Em todos os estudos avaliados foram relatados efeitosadversos referentes ao uso dos canabinóides (4 a 14%) dos pacientes. Após análise dosartigos pode-se concluir que o uso de derivados canabinóides é eficaz para o tratamento deepilepsias refratárias ao tratamento em pacientes pediátrico com efeitos adversos em geralmais leves que as DAEs, contudo não foi possível estabelecer um padrão de dosagem paracada síndrome.

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“…Regarding the onset of obesity, the AEA can act in two different ways in the CNS. The rst occurs via the mesolimbic system, acting to encourage the search for palatable foods (capable of providing pleasure); and the second is through the hypothalamus, where modulates appetite by regulating the release of orexigenic or anorectic substances [11]. Basically, EC signaling in the hypothalamus consists of modulating feeding by decreasing satiety signals and increasing orexigenic signals.…”

Section: Introductionmentioning

confidence: 99%

Pharmacophore-based Virtual Screening From Phytocannabinoids for Anti-obesity Activity

Correia

Ferreira

Lima

et al. 2021

Preprint

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Search for new pharmacological alternatives for obesity is based on the design and development of compounds that can aid in weight loss so that they can be used safely and effectively over a long period while maintaining their function. The endocannabinoid system is related to obesity by increasing orexigenic signals and reducing satiety signals. Cannabis sativa is a medicinal plant of polypharmaceutical potential that has been widely studied for various medicinal purposes. The in silico evaluation of their natural cannabinoids (also called phytocannabinoids) for anti-obesity purpose stems from the existence of synthetic cannabinoid compounds that have already presented this result, but which did not guarantee patient safety. In order to find new molecules from C. sativa phytocannabinoids, with the potential to interact with the pharmacological target cannabinoid receptor 1, a pharmacophore-based virtual screening was performed, including the evaluation of physicochemical, pharmacokinetic, toxicological predictions and molecular docking. The results obtained from the ZINC12 database pointed to Zinc 69 (ZINC33053402) and Zinc 70 (ZINC19084698) molecules as promising anti-obesity agents. Molecular Dynamics (MD) studies discloses that both complexes were stable by analyzing the RMSD (Root Mean Square Deviation) values, and the binding free energy values demonstrate that the selected structures can interact and inhibit their catalytic activity.

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O sistema endocanabinóide: novo paradigma no tratamento da síndrome metabólica

Cited by 10 publications

References 52 publications

The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans

The endocannabinoid system in zebrafish and its potential to study the effects of Cannabis in humans

Eficácia do uso de Canabidiol em pacientes pediátricos com epilepsia refratária ao tratamento: uma revisão sistemática

Pharmacophore-based Virtual Screening From Phytocannabinoids for Anti-obesity Activity

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