2006
DOI: 10.1590/s0004-27302006000200022
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Abstract: In the past years, in Brazil and in developed countries, obesity has become a major public health problem. It was identified that besides DM2 and metabolic syndrome other clinical entities were associated with insulin resistance. In this review we describe some of these alterations emphasizing nonalcoholic fatty liver disease, but also including polycistic ovary disease, hyperuricemia, chronic renal failure, heart failure, cognitive decline and cancer.

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Cited by 26 publications
(36 citation statements)
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“…The following clinical parameters were assessed: body mass index (BMI), calculated by the formula weight (kg)/height (m) 2 ; measurements of the waist and hip circumferences, taken, respectively, at the umbilical scar and trochanters levels, with the use of a measuring tape; arterial blood pressure taken from left arm extended at the level of the precordium, using a mercury sphygmomanometer.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…The following clinical parameters were assessed: body mass index (BMI), calculated by the formula weight (kg)/height (m) 2 ; measurements of the waist and hip circumferences, taken, respectively, at the umbilical scar and trochanters levels, with the use of a measuring tape; arterial blood pressure taken from left arm extended at the level of the precordium, using a mercury sphygmomanometer.…”
Section: Methodsmentioning
confidence: 99%
“…However, the free testosterone levels may remain normal or reduced, depending on the severity of obesity (1)(2)(3). Several theories have been proposed to explain the decrease in the total and free testosterone levels, including the direct inhibition of testicular production by insulin and leptin, elevation of estrogen concentrations and alteration in the secretion of gonadotrophins (1,(4)(5)(6)(7).…”
mentioning
confidence: 99%
“…Insulin resistance secondary to hyperinsulinemia generates chronic subclinical inflammation and leads to increased levels of interleukins, prostaglandins and certain cytokines 3,4 .…”
Section: Introductionmentioning
confidence: 99%
“…Stephanye Felicye Armecy Mieldazis, 1 Ligia Ajaime Azzalis, 2 Virginia Berlanga Campos Junqueira, 3 Fabíola Isabel Suano Souza, 4 Roseli Oselka Sacardo Sarni, 5 Fernando Luiz Affonso Fonseca 6 hyperinsulinism may signal the development of several metabolic disorders 4 associated with cardiovascular disease (CVD).…”
Section: Introductionmentioning
confidence: 99%
“…Insulin resistance (IR) is defined as a state of subnormal biological response to serum insulin levels, 5,6 and is frequently associated with hyperinsulinism in an attempt to obtain an adequate physiological response. 4,6,7 One of the indicators used for IR assessment is the homeostasis model assessment -insulin resistance index (HOMA-IR).…”
Section: Introductionmentioning
confidence: 99%