2006
DOI: 10.1590/s0004-27302006000100012
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Abstract: RESUMOA acromegalia é uma doença de alta mortalidade, especialmente em razão de complicações cardiovasculares. Com o objetivo de avaliar os fatores determinantes da hipertrofia ventricular esquerda (HVE) e as alterações cardíacas na acromegalia, analisamos 40 acromegálicos submetidos a exames clínico-laboratoriais e ao ecocardiograma. As variáveis analisadas foram idade, sexo, duração de doença, hipertensão arterial (HA), intolerância à glicose/DM, uso ou não de octreotide, GH e %IGF-I. Na análise univariada, … Show more

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Cited by 15 publications
(8 citation statements)
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“…Although not the only factor responsible for cardiac involvement in acromegaly, the coexistence of high blood pressure levels worsens the effects of acromegalic cardiomyopathy (10), as previously observed (11). There were no differences between hypertensive and normotensive acromegalic patients regarding GH and IGF-1 levels; patient with active acromegaly were less frequently hypertensive than those with cured/controlled disease.…”
Section: Discussionmentioning
confidence: 52%
See 1 more Smart Citation
“…Although not the only factor responsible for cardiac involvement in acromegaly, the coexistence of high blood pressure levels worsens the effects of acromegalic cardiomyopathy (10), as previously observed (11). There were no differences between hypertensive and normotensive acromegalic patients regarding GH and IGF-1 levels; patient with active acromegaly were less frequently hypertensive than those with cured/controlled disease.…”
Section: Discussionmentioning
confidence: 52%
“…The presence of a specific acromegalic cardiomyopathy characterized by interstitial fibrosis and mediated by GH and IGF-1 has also been described (4). The coexistence of hypertension, left ventricular hypertrophy, and cardiomyopathy accounts for most of the cardiovascular impairment in acromegalic patients (9)(10)(11).…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, the excess of GH and IGF-I may directly cause cardiac abnormalities [1,4,5]. Some reports have suggested that acromegaly can cause a typical cardiomyopathy characterized by a concentric ventricular hypertrophy, impairment of diastolic function, and additionally, a progressive impairment of systolic performance [6][7][8].…”
Section: Introductionmentioning
confidence: 99%
“…Its prevalence is variable, between 25% and 100% in different series, which is related to the different populations studied (86,(89)(90)(91)(92). Its most common feature is left ventricular hypertrophy (LVH) (93,94), which was present in 57.5% of our patients (85). In that study, hypertension and IGF-I were independent determinant factors of LHV (85).…”
Section: Etiology and Management Of Acromegalymentioning
confidence: 62%
“…Its prevalence has been reported to range from 18 to 60% in different clinical series (81)(82)(83), with a mean prevalence of about 35% (84). In a study from our group its prevalence was 47.5% (85). Hypertension in acromegaly is generally mild, uncomplicated, and easily controlled with standard antihypertensive medications (84).…”
Section: Evaluation Of the Anterior Pituitary Functionmentioning
confidence: 99%