Hormônios tiroideanos: mecanismo de ação e importância biológica

Nunes, Maria Tereza

doi:10.1590/s0004-27302003000600004

Cited by 19 publications

(19 citation statements)

References 19 publications

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“…Chlorhexidine gluconate was used in the antisepsis because it does not interfere with thyroid metabolism 21 . Patients with severe hypothyroidism present chronic peripheral vasoconstriction.…”

Section: Discussionmentioning

confidence: 99%

Tracheal suture in rats with hypothyroidism: wound healing study

et al. 2009

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Purpose:To evaluate the influence of hypothyroidism in tracheal wound healing process. Methods: A controlled study was designed with 48 male Wistar rats, divided into two groups: study and control groups. In the first one hypothyroidism was surgically induced and 10 weeks after, a tracheal opening followed by suture was performed in both groups, subdivided into 7, 14, and 21 days in accordance with the date of animals death. A laboratorial evaluation was performed to prove the decreased in thyroid function in the study group. Also a macroscopic evaluation through a stablished protocol and a microscopic analysis with Hematoxylin-eosin and Sirius-Red staining methods were done. Results: The laboratorial evaluation certified suppressed thyroid function in the study group. The macroscopic evaluation showed the presence of suture blockade in the study group in all the evaluated days. Microscopic analysis showed a prolongated inflammatory process and less collagen with delay in organization in the study group comparing to control group. All these data were statistic significant. Conclusion: Hypothyroidism had an influence in tracheal wound healing process, promoting delay in the inflammatory and organization processes and diminished tissue collagen quantity. Key words: Wound Healing. Hypothyroidism. Trachea. Rats. RESUMOObjetivo: Investigar a influência que o hipotireoidismo exerce no processo cicatricial da traquéia. Métodos: Estudo controlado, com 48 ratos Wistar machos, divididos em dois grupos, denominados: grupo estudo e grupo controle. No primeiro induziu-se hipotireoidismo cirurgicamente e após 10 semanas, realizou-se nos dois grupos o procedimento de abertura traqueal seguida de sutura. Houve subdivisão destes grupos em 7, 14 e 21 dias, de acordo com a data de morte dos animais. Foi realizada avaliação laboratorial para comprovar o hipotireoidismo no grupo estudo, avaliação macroscópica e microscópica através das colorações de hematoxilina-eosina e Sirius Red. Resultados: A avaliação laboratorial atestou que o grupo estudo encontrava-se em estado de hipotireoidismo. A avaliação macroscópica demonstrou predomínio de bloqueio da sutura no grupo estudo em todos os momentos avaliados. A microscopia comprovou prolongamento da fase inflamatória e diminuição da quantidade total de colágeno bem como atraso na sua organização no grupo estudo em relação ao grupo controle. Todos estes dados apresentaram significância estatística. Conclusão: O hipotireoidismo influencia no processo de cicatrização traqueal prolongando a fase inflamatória, diminuindo a quantidade de colágeno e atrasando sua maturação e organização. Descritores: Cicatrização de Feridas. Hipotireoidismo. Traquéia. Ratos.

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Section: Discussionmentioning

confidence: 99%

Tracheal suture in rats with hypothyroidism: wound healing study

et al. 2009

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“…The thyroid follicles present extensive blood and lymphatic vascular supply, the former responsible for collecting the hormones produced by the gland. This organ is an excellent bioindicator in toxicology studies, once it is very sensitive to toxic exposure, even in minimum dosages [22,23].…”

Section: Doi: 107243/2055-091x-4-9mentioning

confidence: 99%

“…These results confirm the thyroid sensitivity to alterations (even the slightest ones) in the organism of the animals, once in the bioassays using only propylene glycol 10% and the solvent ethanol 30% it was possible to observe alterations in this gland, confirming that the thyroid is an excellent toxicity indicator for vertebrate. Contrarily, the thyroid of the mice belonging to control group I was intact, as described in the literature [21][22][23], which was expected, once only distilled water was used in the exposure.…”

Section: Thyroidmentioning

confidence: 99%

Histopathological changes in the liver and thyroid of mice (Mus musculus) caused by the acaricides: fipronil and thymol

Cunha¹,

Matos²,

Pereira³

et al. 2017

J Histol Histopathol

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The control of tick Rhipicephalus (Boophilus) microplus, that has the cattle as preferential host, has been performed using products based on different chemical substances. However, the indiscriminate use of these products has caused the selection of resistant populations and damages to the environment, contaminating the soil and water. Tickcides, like fipronil (synthetic chemical) and thymol (natural chemical), are applied on cattle through aspersion, causing the death of the ectoparasites. Nevertheless, the effects of these products on nontarget organisms have not been thoroughly investigated. Thus, this study evaluated the morphology of the liver and thyroid of female Mus musculus mice, divided into 5 treatment groups/5 individuals each, exposed to fipronil (2%) and thymol (2 mg/mL) through aspersion baths. After exposure, the mice were euthanized with anaesthetic overdose and dissected for organ removal. The results showed that both fipronil and thymol caused morphological alterations in the organs: cytoplasmic vacuolation, cell death characteristics in hepatocyte nuclei and structural disorganization of the thyroid gland. Along with body weight measurement, the results suggest that the morphological alterations would be a systemic response of the organism to the toxic action of these products, regardless their origin (synthetic of natural).

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“…Therefore, in the presence of CH, the decreasing of the absolute size of the cerebellum and brain can be observed, as well as atrophy of the cerebral convolutions. These irreversible damages to neuronal tissue not only cause intellectual disabilities, but other neurological, metabolic and maturational changes that may reflect difficulties in oral communication and learning processes 4 . Thyroid hormones depend on vascularization processes of CNS myelination, dendritic branching, synapse formation, neuronal migration, cell differentiation and gene expression.…”

Section: Literature Reviewmentioning

confidence: 99%

Hipotireoidismo congênito: influência para as habilidades linguísticas e comportamentais: estudo de revisão

Anastácio-Pessan

CusinLamônica

2014

Rev. CEFAC

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fifth month of pregnancy and after birth, depending on the type of process and its location in the brain, adequate levels of thyroid hormone are essential 4. The deleterious effects of lack of thyroid hormones during pregnancy can be avoided by transplacental transfer of hormones from mother to fetus 1,5 , however, from birth to maternal hormone transfer to the fetus disappears, and those newborns untreated after the third month of life usually present delayed physical and cognitive development, with the possibility of intellectual disability of varied grade 5. Already in the first three months of life, children with CH may present clinical signs of this metabolic alteration, such as lethargy, drowsiness, hypotonia, hypothermia, prolonged jaundice, edema, puffy eyes, large fontanelles, bloating, goiter, macroglossia, "facies syndrome", hoarse cry, nasal obstruction, difficulty breastfeeding, breathing difficulties, constipation, cold skin, pale, dry, scaly and carotenemia and umbilical hernia. After the third month, these signals become increasingly evident and delayed

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Hormônios tiroideanos: mecanismo de ação e importância biológica

Cited by 19 publications

References 19 publications

Tracheal suture in rats with hypothyroidism: wound healing study

Tracheal suture in rats with hypothyroidism: wound healing study

Histopathological changes in the liver and thyroid of mice (Mus musculus) caused by the acaricides: fipronil and thymol

Hipotireoidismo congênito: influência para as habilidades linguísticas e comportamentais: estudo de revisão

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