The central role of RNA in the genetic programming of complex organisms

Mattick, John S.

doi:10.1590/s0001-37652010000400016

Cited by 21 publications

(11 citation statements)

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“…For further information, readers are referred to reviews on various subtopics: intron evolution and function [103]; the significance of non-coding RNAs in organism complexity and evolution [104, 105, 108, 147]; functions of non-coding RNAs [2, 112], including regulation of transcription [70, 127], epigenetic processes [109, 127], structural roles [191], and response to environmental stimuli [180]; small regulatory RNAs in mammals [110]; non-coding RNAs in the human brain and development [107, 117] and in the nervous system [117]; and the involvement of non-coding RNAs in disease [173]. …”

Section: Non-coding Rnasmentioning

confidence: 99%

Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements

Barrett

Fletcher

Wilton

2012

Cell. Mol. Life Sci.

465

376

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There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5′ and 3′ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This review discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.

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Section: Non-coding Rnasmentioning

confidence: 99%

Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements

Barrett

Fletcher

Wilton

2012

Cell. Mol. Life Sci.

465

376

View full text Add to dashboard Cite

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“…The rise of epigenetics is more than an epiphenomenon within molecular biology. It marks an important perspective in which the given genetic information is marked according to different expression patterns depending on the tissue specificity and according to environmental conditions that make it necessary to change expression patterns [ 102 , 103 ]. One could see it as an environmental memory of the available genetic information according to adaptational needs: one genome out of which multiple cell types can be processed.…”

Section: Inheritable Conservation Of New Experiencesmentioning

confidence: 99%

RNA Sociology: Group Behavioral Motifs of RNA Consortia

Witzany¹

2014

Life

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RNA sociology investigates the behavioral motifs of RNA consortia from the social science perspective. Besides the self-folding of RNAs into single stem loop structures, group building of such stem loops results in a variety of essential agents that are highly active in regulatory processes in cellular and non-cellular life. RNA stem loop self-folding and group building do not depend solely on sequence syntax; more important are their contextual (functional) needs. Also, evolutionary processes seem to occur through RNA stem loop consortia that may act as a complement. This means the whole entity functions only if all participating parts are coordinated, although the complementary building parts originally evolved for different functions. If complementary groups, such as rRNAs and tRNAs, are placed together in selective pressure contexts, new evolutionary features may emerge. Evolution initiated by competent agents in natural genome editing clearly contrasts with statistical error replication narratives.

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“…Noncoding RNAs (ncRNAs) are an attractive research field to prompt extensive genome-wide transcriptional efforts by different international initiatives such as the Encyclopedia of DNA Elements (ENCODEs) [1] and the Functional Annotation of the Mammalian Genome (FANTOM) [2]. Existence of ncRNAs is ubiquitous to all three domains of life, but they play different roles according to type of its RNA family [3,4]. Dysfunction of ncRNAs may lead to various human diseases from tumorigenesis to neurological, cardiovascular, and developmental disorders [5].…”

Section: Introductionmentioning

confidence: 99%